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Therapeutic role of medicinal plant extracts and bioactive compounds in osteoarthritis

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Abstract

Osteoarthritis (OA) is a musculoskeletal disorder characterized by degeneration of articular cartilages facilitated by inflammation, cartilage and extracellular matrix degrading enzymes and chondrocyte dedifferentiation and depletion. The current therapy for OA failed to avert the degeneration of articular cartilage due to elusive molecular nature, multifarious signaling pathway and molecular targets implicated in this disease. These reasons are imposing hefty economic burden globally which necessitate for the discovery and development of multi-action drugs capable of stunting diseased condition. Medicinal plants accommodate various bioactive compounds that have a role in regulating inflammation and tissue regenerative properties. These compounds and plant extracts interact with multiple drug targets and disease pathways which make them attractive candidate for OA therapy. Recently, numerous compounds have been explored in OA induced animal and cell line models that significantly improved the cartilage integrity, extracellular matrix production and chondrocyte survival. In this review, we reviewed medicinal plant extracts and bioactive components and their therapeutic influence in OA therapy.

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Abbreviations

TQ:

Thymoquinone

NFκB:

Nuclear Factor kappa B

TIMP-1:

Tissue Inhibitor Matrix Metalloproteinase-1

MMP:

Matrix Metalloproteinase

IL-1β:

Interleukin-1 Beta

COX-2:

Cyclooxygenase-2

PI3K:

Phosphoinositide-3-kinase

pERK:

Protein kinase R like endoplasmic reticulum kinase

MAPK:

Mitogen Activated Protein Kinase

PGE2 :

Prostaglandin E2

NO:

Nitric oxide

TNF-α:

Tumor Necrosis Factor Alpha

ADAMTS:

A disintegrin and Metalloproteinase with thrombospondin motifs

SOX9:

SRY-Box Transcription Factor-9

RUNX-2:

Runt related Transcription Factor-2

JNK:

C-JUN N-terminal Kinase

AKT:

Serine/Threonine protein kinase

mTOR:

Mechanistic target of rapamycin

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Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF) funded by the Korean Government (MEST) (2020R1I1A306969912).

Funding

This work was supported by the National Research Foundation of Korea (NRF) funded by the Korean Government (MEST) (2020R1I1A306969912).

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Authors and Affiliations

  1. Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, 32588, Republic of Korea

    Fahad Hassan Shah & Song Ja Kim

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  1. Fahad Hassan Shah
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  2. Song Ja Kim
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All authors contributed equally to the development of this article.

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Correspondence to Song Ja Kim.

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Ethical statement

This article does not contain any studies involving animals performed by any of the authors. This article does not contain any studies involving human participants performed by any of the authors.

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Fahad Hassan Shah has no conflict of interest. Song Ja Kim has no conflict of interest.

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Shah, F.H., Kim, S.J. Therapeutic role of medicinal plant extracts and bioactive compounds in osteoarthritis. ADV TRADIT MED (ADTM) 22, 837–844 (2022). https://doi.org/10.1007/s13596-022-00635-5

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