Preclinical evaluation of Kali Haldi (Curcuma caesia): a promising herb to treat type-2 diabetes

Abstract

The methanol extract of Curcuma caesia (MECC) rhizome showed antidiabetic activity by lowering blood glucose in in vivo studies and controlled intestinal absorption of monosaccharides by inhibiting alpha amylase and alpha glucosidase. It also enhanced the glucose uptake in yeast cells, proving proper glucose utilization. The IC50 values of MECC were found to be 442.92 ± 10.05 μg/ml and 95.40 ± 9.74 μg/ml in alpha amylase and alpha glucosidase inhibition respectively. The extract has effective antioxidant activities, by successfully scavenging free radicals like superoxide and hydroxyl ions. The histopathological studies of pancreas showed gradual healing after treatment.

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Acknowledgement

The authors are thankful to the Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Kolkata, India for providing necessary infrastructure and help. AICTE, India for providing necessary funds. They also want to thank Department of Science and Technology Inspire program, New Delhi, India,IF-140101.

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Correspondence to Pallab Kanti Haldar.

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All the procedures described were reviewed and approved by the University Animal Ethical Committee.

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The authors declare that they have no conflict of interest.

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Majumder, P., Mazumder, S., Chakraborty, M. et al. Preclinical evaluation of Kali Haldi (Curcuma caesia): a promising herb to treat type-2 diabetes. Orient Pharm Exp Med 17, 161–169 (2017). https://doi.org/10.1007/s13596-017-0259-9

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Keywords

  • Antidiabetic
  • Alpha amylase
  • Alpha glucosidase
  • Glucose uptake
  • Antioxidants