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microRNA-4270-5p inhibits cancer cell proliferation and metastasis in hepatocellular carcinoma by targeting SATB2

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Abstract

Hepatocellular carcinoma (HCC) remains a lethal cancer type for both males and females. MicroRNAs (miRNAs) contribute to the initiation, development and metastasis of cancer. Although several miRNAs have been identified as drivers or suppressors of HCC, the molecular mechanisms of many miRNAs have not been investigated. Currently, we discovered that miR-4270-5p was a significantly downregulated miRNA in HCC. We revealed that miR-4270-5p overexpression inhibited cell proliferation and invasion of HCC cells. The data manifested that miR-4270-5p directly targeted SATB2, a key regulator of epithelial mesenchymal transition (EMT), in HCC cells and reversed the EMT process. The rescue experiments suggested that SATB2 overexpression reversed the biological function of miR-4270-5p in HCC cells. Clinical data indicated that SATB2 expression was negatively correlated with miR-4270-5p levels in HCC patients. Our findings provided potential targets for prognosis and treatment of patients with HCC.

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Authors and Affiliations

  1. Department of Internal Medicine, Liver and Biliary Disease Hospital of Jilin Province, Changchun, Jilin, China

    Yun Wang

  2. Department of Endoscopy Center, The China-Japan Union Hospital of Jilin University Hospital, Changchun, Jilin, China

    Chang-feng Li

  3. Department of Gastrointestinal Colorectal Surgery, The China-Japan Union Hospital of Jilin University, Xiantai Road No.126, Changchun, 130033, Jilin, China

    Li-bo Sun & Yong-chao Li

Authors
  1. Yun Wang
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  2. Chang-feng Li
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  3. Li-bo Sun
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  4. Yong-chao Li
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Correspondence to Yong-chao Li.

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All the authors declare that they have no competing interests of any type in the current study.

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The study was performed in accordance with the Declaration of Helsinki and obtained the approval from the Ethics Committee of the China-Japan Union Hospital of Jilin University.

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Wang, Y., Li, Cf., Sun, Lb. et al. microRNA-4270-5p inhibits cancer cell proliferation and metastasis in hepatocellular carcinoma by targeting SATB2. Human Cell 33, 1155–1164 (2020). https://doi.org/10.1007/s13577-020-00384-0

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  • DOI: https://doi.org/10.1007/s13577-020-00384-0

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