Abstract
Special AT-rich sequence-binding protein 2 (SATB2) is a transcription factor, which plays an important role in transcriptional regulation and chromatin recombinant by combining with matrix attachment regions. More evidence shows that SATB2 is involved in progression of breast cancer, head and neck squamous cell carcinomas and osteosarcoma. However, the role of SATB2 in cancer initiation and progression is still not well understood. Our study identified that decreased expression of SATB2 was correlated with tumor progression and poor prognosis in non-small cell lung cancer (NSCLC) patients. Furthermore, SATB2 suppressed lung cancer cell invasion and metastasis and regulated the expression of EMT-related proteins and histone methylation by G9a. In summary, SATB2 may act as a tumor suppressor gene in NSCLC.
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Abbreviations
- SATB2:
-
Special AT-rich sequence-binding protein 2
- MARs:
-
Matrix attachment regions
- NSCLC:
-
Non-small cell lung cancer
- EMT:
-
Epithelial to mesenchymal transition
- HMT:
-
Histone lysine methyltransferase
- HNSCC:
-
Head and neck squamous cell carcinoma
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Acknowledgments
We thank Yu-chen Han, Yi-nan Ma and Hai-yan Zhang for their constructive comments and suggestions on the manuscript, Liang-Ru Fei, Mei-Yu Zhang, Cong-Cong Wang and Yuan Luo for technical support. Yinan Ma takes responsibility for the integrity of the article. We also thank National Natural Science Foundation of China (No. 81272605) for supporting this study.
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The study protocol conforms to the ethical guidelines of the World Medical Association, Declaration of Helsinki—Ethical Principles for Medical Research Involving Human Subjects adopted by the 18th WMA General Assembly, Helsinki, Finland, June 1964, and amended by the 64th WMA General Assembly, Fortaleza, Brazil, October 2013, as reflected in a priori approval by the appropriate institutional review committee. The Hospital General Universitario Ethic’s Committee approved the protocol, and all patients gave their informed consent for the inclusion in the study.
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Ma, Yn., Zhang, HY., Fei, LR. et al. SATB2 suppresses non-small cell lung cancer invasiveness by G9a. Clin Exp Med 18, 37–44 (2018). https://doi.org/10.1007/s10238-017-0464-3
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DOI: https://doi.org/10.1007/s10238-017-0464-3