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GSTM1, GSTT1, and NQO1 polymorphisms in cervical carcinogenesis

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Abstract

The aim of the study is to investigate the clinical significance of glutathione-S-transferase GSTM1, GSTT1, and NQO1 c.609C>T (rs1800566) genetic polymorphisms in cervical carcinogenesis. GSTM1, GSTT1, and NQO1 polymorphisms together with human papillomavirus (HPV) types were examined in a total of 192 cervical smear in exfoliated cervical cell samples using polymerase chain reaction (PCR) system and real-time polymerase chain reaction (PCR) system. The 19 patients with high-grade squamous intraepithelial lesion had statistically higher frequency of null GSTT1 genotype than 9 with low-grade squamous intraepithelial lesion (LSIL) among the 67 patients with high-risk HPV (P = 0.024). The 24 patients with HSIL had also statistically higher frequency of NQO1 (CT+TT) genotype than 14 with LSIL among the 67 patients with high-risk HPV (P = 0.024). GSTT1 null and NQO1 genotype in cervical cell samples may be associated with more severe precancerous lesions of the cervix in a Japanese population.

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Authors and Affiliations

  1. Department of Medical Technology, Kobe Tokiwa University, 6-2 2 chome, Ohtanicho, Nagata-ku, Kobe, Hyogo, 6530838, Japan

    Osamu Nunobiki

  2. Cytopathology and Gynecology, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan

    Masatsugu Ueda, Hikari Akise, Shinji Izuma, Kiyo Torii, Yoshiaki Okamoto, Ichiro Tanaka & Sadamu Noda

  3. Department of Obstetrics and Gynecology, Kyoto Prefectural University, Kyoto, Japan

    Kyoko Akashi

  4. Department of Obstetrics and Gynecology, Akou City Hospital, Akou, Hyogo, Japan

    Taro Higashida

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  1. Osamu Nunobiki
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  2. Masatsugu Ueda
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  4. Shinji Izuma
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Correspondence to Osamu Nunobiki.

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Nunobiki, O., Ueda, M., Akise, H. et al. GSTM1, GSTT1, and NQO1 polymorphisms in cervical carcinogenesis. Human Cell 28, 109–113 (2015). https://doi.org/10.1007/s13577-015-0111-9

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  • DOI: https://doi.org/10.1007/s13577-015-0111-9

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