Armstrong AW, Read C. Pathophysiology, clinical presentation, and treatment of psoriasis: a review. JAMA. 2020;323:1945–60.
CAS
PubMed
Article
Google Scholar
Gelfand JM, Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB. Risk of myocardial infarction in patients with psoriasis. JAMA. 2006;296:1735–41.
CAS
PubMed
Article
Google Scholar
Valaiyaduppu Subas S, Mishra V, Busa V, et al. Cardiovascular involvement in psoriasis, diagnosing subclinical atherosclerosis, effects of biological and non-biological therapy: a literature review. Cureus. 2020;12:e11173.
PubMed
PubMed Central
Google Scholar
Armstrong EJ, Harskamp CT, Armstrong AW. Psoriasis and major adverse cardiovascular events: a systematic review and meta-analysis of observational studies. J Am Heart Assoc. 2013;2:e000062.
PubMed
PubMed Central
Article
Google Scholar
Kim BS, Lee WK, Pak K, et al. Ustekinumab treatment is associated with decreased systemic and vascular inflammation in patients with moderate-to-severe psoriasis: feasibility study using (18)F-fluorodeoxyglucose PET/CT. J Am Acad Dermatol. 2019;80:1322–31.
CAS
PubMed
Article
Google Scholar
Gelfand JM, Shin DB, Alavi A, et al. A phase IV, randomized, double-blind, placebo-controlled crossover study of the effects of ustekinumab on vascular inflammation in psoriasis (the VIP-U Trial). J Invest Dermatol. 2020;140:85–93.
CAS
PubMed
Article
Google Scholar
Gelfand JM, Shin DB, Duffin KC, et al. A randomized placebo-controlled trial of secukinumab on aortic vascular inflammation in moderate-to-severe plaque psoriasis (VIP-S). J Invest Dermatol. 2020;140:1784–93.
CAS
PubMed
Article
PubMed Central
Google Scholar
Verhaar BJH, Prodan A, Nieuwdorp M, Muller M. Gut microbiota in hypertension and atherosclerosis: a review. Nutrients. 2020;12:2982.
CAS
PubMed Central
Article
Google Scholar
Zhou W, Cheng Y, Zhu P, Nasser MI, Zhang X, Zhao M. Implication of gut microbiota in cardiovascular diseases. Oxid Med Cell Longev. 2020;2020:5394096.
PubMed
PubMed Central
Google Scholar
Nowinski A, Ufnal M. Trimethylamine N-oxide: a harmful, protective or diagnostic marker in lifestyle diseases? Nutrition. 2018;46:7–12.
CAS
PubMed
Article
Google Scholar
Farhangi MA, Vajdi M, Asghari-Jafarabadi M. Gut microbiota-associated metabolite trimethylamine N-oxide and the risk of stroke: a systematic review and dose-response meta-analysis. Nutr J. 2020;19:76.
CAS
PubMed
PubMed Central
Article
Google Scholar
Buttner P, Okun JG, Hauke J, et al. Trimethylamine N-oxide in atrial fibrillation progression. Int J Cardiol Heart Vasc. 2020;29:100554.
PubMed
PubMed Central
Google Scholar
Bin Waleed K, Lu Y, Liu Q, et al. Association of trimethylamine N-oxide with coronary atherosclerotic burden in patients with non-ST-segment elevation myocardial infarction. Medicine (Baltimore). 2020;99:e20794.
CAS
Article
Google Scholar
Zhang Y, Wang Y, Ke B, Du J. TMAO: how gut microbiota contributes to heart failure. Transl Res. 2021;228:109–25.
CAS
PubMed
Article
Google Scholar
Gregory JC, Buffa JA, Org E, et al. Transmission of atherosclerosis susceptibility with gut microbial transplantation. J Biol Chem. 2015;290:5647–60.
CAS
PubMed
Article
Google Scholar
Sikora M, Chrabaszcz M, Maciejewski C, et al. Intestinal barrier integrity in patients with plaque psoriasis. J Dermatol. 2018;45:1468–70.
CAS
PubMed
Article
Google Scholar
Sikora M, Chrabaszcz M, Waskiel-Burnat A, Rakowska A, Olszewska M, Rudnicka L. Claudin-3—a new intestinal integrity marker in patients with psoriasis: association with disease severity. J Eur Acad Dermatol Venereol. 2019;33:1907–12.
CAS
PubMed
Article
Google Scholar
Sikora M, Stec A, Chrabaszcz M, et al. Intestinal fatty acid binding protein, a biomarker of intestinal barrier, is associated with severity of psoriasis. J Clin Med. 2019;8:1021.
CAS
PubMed Central
Article
Google Scholar
Hemann BA, Bimson WF, Taylor AJ. The Framingham Risk Score: an appraisal of its benefits and limitations. Am Heart Hosp J. 2007;5:91–6.
PubMed
Article
Google Scholar
Collins GS, Altman DG. An independent and external validation of QRISK2 cardiovascular disease risk score: a prospective open cohort study. BMJ. 2010;340:c2442.
PubMed
PubMed Central
Article
Google Scholar
Goff DC Jr, Lloyd-Jones DM, Bennett G, et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129:S49-73.
PubMed
Article
Google Scholar
Trzeciak B, Siebert J, Gutknecht P, Molisz A, Filipiak KJ, Wozakowska-Kaplon B. Cardiovascular risk factors determined via the Internet in 2 periods of time: 2004–2009 and 2010–2015 in Poland. Int J Occup Med Environ Health. 2017;30:499–510.
PubMed
Google Scholar
Ridker PM, Buring JE, Rifai N, Cook NR. Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. JAMA. 2007;297:611–9.
CAS
PubMed
Article
Google Scholar
Jaworska K, Huc T, Samborowska E, et al. Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite. PLoS ONE. 2017;12:e0189310.
PubMed
PubMed Central
Article
CAS
Google Scholar
Skrzypecki J, Izdebska J, Kaminska A, et al. Glaucoma patients have an increased level of trimethylamine, a toxic product of gut bacteria, in the aqueous humor: a pilot study. Int Ophthalmol. 2021;41:341–7.
PubMed
Article
Google Scholar
Gelfand JM, Dommasch ED, Shin DB, et al. The risk of stroke in patients with psoriasis. J Invest Dermatol. 2009;129:2411–8.
CAS
PubMed
PubMed Central
Article
Google Scholar
Kimball AB, Robinson D Jr, Wu Y, et al. Cardiovascular disease and risk factors among psoriasis patients in two US healthcare databases, 2001–2002. Dermatology. 2008;217:27–37.
CAS
PubMed
Article
Google Scholar
Rhee TM, Lee JH, Choi EK, et al. Increased risk of atrial fibrillation and thromboembolism in patients with severe psoriasis: a nationwide population-based study. Sci Rep. 2017;7:9973.
PubMed
PubMed Central
Article
CAS
Google Scholar
Sunbul M, Agirbasli M. Psoriasis and atherosclerosis: is there a need for novel biomarkers assessing cardiovascular risk? Curr Pharm Des. 2014;20:529–35.
CAS
PubMed
Article
Google Scholar
Eder L, Gladman DD. Atherosclerosis in psoriatic disease: latest evidence and clinical implications. Ther Adv Musculoskelet Dis. 2015;7:187–95.
CAS
PubMed
PubMed Central
Article
Google Scholar
Puig L. Cardiometabolic comorbidities in psoriasis and psoriatic arthritis. Int J Mol Sci. 2017;19:58.
PubMed Central
Article
CAS
Google Scholar
Yeh CF, Chen YH, Liu SF, et al. Mutual interplay of host immune system and gut microbiota in the immunopathology of atherosclerosis. Int J Mol Sci. 2020;21:8729.
CAS
PubMed Central
Article
Google Scholar
Sikora M, Stec A, Chrabaszcz M, et al. Gut microbiome in psoriasis: an updated review. Pathogens. 2020;9:463.
CAS
PubMed Central
Article
Google Scholar
Romani J, Caixas A, Escote X, et al. Lipopolysaccharide-binding protein is increased in patients with psoriasis with metabolic syndrome, and correlates with C-reactive protein. Clin Exp Dermatol. 2013;38:81–4.
CAS
PubMed
Article
Google Scholar
Ramirez-Bosca A, Navarro-Lopez V, Martinez-Andres A, et al. Identification of bacterial DNA in the peripheral blood of patients with active psoriasis. JAMA Dermatol. 2015;151:670–1.
PubMed
Article
Google Scholar
Coras R, Kavanaugh A, Boyd T, et al. Choline metabolite, trimethylamine N-oxide (TMAO), is associated with inflammation in psoriatic arthritis. Clin Exp Rheumatol. 2019;37:481–4.
PubMed
PubMed Central
Google Scholar
Duttaroy AK. Role of gut microbiota and their metabolites on atherosclerosis, hypertension and human blood platelet function: a review. Nutrients. 2021;13:144.
CAS
PubMed Central
Article
Google Scholar
Yang S, Li X, Yang F, et al. Gut microbiota-dependent marker TMAO in promoting cardiovascular disease: inflammation mechanism, clinical prognostic, and potential as a therapeutic target. Front Pharmacol. 2019;10:1360.
CAS
PubMed
PubMed Central
Article
Google Scholar
Boini KM, Hussain T, Li PL, Koka S. Trimethylamine-N-oxide instigates NLRP3 inflammasome activation and endothelial dysfunction. Cell Physiol Biochem. 2017;44:152–62.
PubMed
Article
Google Scholar
Sun X, Jiao X, Ma Y, et al. Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome. Biochem Biophys Res Commun. 2016;481:63–70.
CAS
PubMed
Article
Google Scholar
Brunt VE, Gioscia-Ryan RA, Casso AG, et al. Trimethylamine-N-oxide promotes age-related vascular oxidative stress and endothelial dysfunction in mice and healthy humans. Hypertension. 2020;76:101–12.
CAS
PubMed
Article
Google Scholar
Geng J, Yang C, Wang B, et al. Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK/JNK pathway. Biomed Pharmacother. 2018;97:941–7.
CAS
PubMed
Article
Google Scholar
Warrier M, Shih DM, Burrows AC, et al. The TMAO-generating enzyme flavin monooxygenase 3 is a central regulator of cholesterol balance. Cell Rep. 2015;10:326–38.
CAS
PubMed
PubMed Central
Article
Google Scholar
Ding L, Chang M, Guo Y, et al. Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism. Lipids Health Dis. 2018;17:286.
CAS
PubMed
PubMed Central
Article
Google Scholar
Zhu W, Gregory JC, Org E, et al. Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk. Cell. 2016;165:111–24.
CAS
PubMed
PubMed Central
Article
Google Scholar
Senthong V, Wang Z, Fan Y, Wu Y, Hazen SL, Tang WH. Trimethylamine N-oxide and mortality risk in patients with peripheral artery disease. J Am Heart Assoc. 2016;5:e004237.
PubMed
PubMed Central
Google Scholar
Jaworska K, Bielinska K, Gawrys-Kopczynska M, Ufnal M. TMA (trimethylamine), but not its oxide TMAO (trimethylamine-oxide), exerts haemodynamic effects: implications for interpretation of cardiovascular actions of gut microbiome. Cardiovasc Res. 2019;115:1948–9.
CAS
PubMed
Article
Google Scholar
Jaworska K, Hering D, Mosieniak G, et al. TMA, a forgotten uremic toxin, but not TMAO, is involved in cardiovascular pathology. Toxins (Basel). 2019;11:490.
CAS
Article
Google Scholar