A number of treatments for atopic dermatitis (AD) are available; however, long-term treatment patterns and healthcare consumption in patients with AD are poorly described.
We conducted a registry-based longitudinal drug utilization study among Danish patients with AD that were referred to their first-ever visit at hospital-based dermatology clinics. Their first visit was in the period between 1 January 2005 and 31 December 2012, and patients were followed up to 5 years after their first visit.
In total, 8213 people with a first-time hospital dermatologist contact for AD were included in the study (3514 aged 0–9 years, 1501 aged 10–19 years, 3198 aged 20 years or older). At first visit, a baseline history of moderately potent topical corticosteroid (TCS) use was seen among 46.6% of children (0–9 years), whereas potent or very potent TCS use was more frequently among older individuals (e.g., 51.1% and 25.6% of people aged 50 years or older had used potent and very potent TCS, respectively). The median (interquartile range) annual number of visits to general practitioners was 4 (2–7) for children and 5 (2–8) for adults, in the 12 months prior to referral. Three years after referral, these numbers had decreased to 2 (1–4) and 3 (1–6), respectively. In the first year after referral, 6% of patients were prescribed systemic corticosteroids, whereas other systemic therapies were used in 5% or less.
After referral, low proportions of patients received systemic treatment, or potent TCS. These findings highlight considerable differences in treatment patterns between general practitioners and private practice dermatologists, compared with hospital-based dermatologists, and emphasize the need for better adherence to evidence-based treatment guidelines.
|Why carry out this study?|
|A number of treatments for atopic dermatitis (AD) are available; however, long-term treatment patterns and healthcare consumption in patients with AD are poorly described.|
|Using nationwide register-data from Denmark, we assessed the use of different treatment patterns and healthcare consumption, before and after referral to specialized hospital-based dermatology clinics, among children and adults with AD in a population-based setting.|
|What was learned from the study?|
|Among topical therapies, the most frequently used treatment modalities when presenting to the hospital were potent and moderately potent TCS. Notably, use of topical antibiotics (alone or in combination with TCS) increased in the last 3–6 months prior to the hospital visit, and decreased thereafter, and use of systemic corticosteroids increased dramatically in the months preceding the initial hospital visit.|
|These findings highlight considerable differences in treatment patterns between general practitioners and private practice dermatologists, compared with hospital-based dermatologists, and emphasize the need for better adherence to evidence-based treatment guidelines.|
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Atopic dermatitis (AD) is an inflammatory skin disease that is characterized by xerosis and intense pruritus , and represents a growing burden to healthcare systems worldwide [2, 3], and may considerably impair patients’ quality of life . Over the past 30 years, its lifetime prevalence has increased rapidly, namely in the industrialized world, where it has now plateaued at 10–20% . While AD typically begins early in life, it may be present in all ages, and the disease course is often waxing and waning, and may be accompanied by respiratory allergy and recurrent skin infections [6,7,8]. The majority of patients (approximately 80%) have mild disease , but a positive family history, early allergen sensitizations, disease onset before 2 years of age, and severe AD early in life appear to be risk factors for more persistent and severe disease in adulthood . The current standard of care includes education and the use emollients, pharmaceutical interventions (topical and systemic treatments), as well as phototherapy. Topical corticosteroids (TCS) are the mainstay of AD therapy, and even in more severe cases when systemic treatment is needed, TCS are often used in conjunction.
Although many guidelines exist, either local or international, data on real-life treatment patterns over time are lacking. Using nationwide register-data from Denmark, we assessed the use of different treatment patterns and healthcare consumption, before and after referral to specialized hospital-based dermatology clinics, among children and adults with AD in a population-based setting.
Treatment and Referral Patterns in Denmark
As a result of the tax-supported healthcare system in Denmark, all residents have equal and unencumbered access to general practitioners, private practicing specialists, and hospital-based treatment without charge. Upon displaying initial symptoms, patients may consult their general practitioner that may initiate treatment or refer patients to specialists. In the majority of cases, referrals are sent to private practice dermatologists, but referrals may also be sent directly to hospital-based clinics if deemed appropriate by the general practitioner, or by internal referral, e.g., by a pulmonologist if the patient is already seen in a hospital setting because of asthma. Private practice dermatologists may initiate treatments with topical or systemic treatments (but not biologics as these are reserved for hospital-based clinics) or phototherapy, or may choose to refer patients to a hospital-based dermatology clinic. Data suggest that less than 3% of patients with AD seen in private practice are treated with systemic therapies, including cyclosporine, methotrexate, and azathioprine . While cyclosporine is a key medication of conventional AD treatment in many countries, and widely recommended in international guidelines, historically it is very rarely used for AD in Denmark [12, 13].
According to national Danish guidelines , treatment of AD should be done in a stepwise approach, using emollients as baseline therapy. Recommendations are that mild-to-moderate AD is treated with low potency (e.g., hydrocortisone) or moderately potent (e.g., hydrocortisone-17-butyrate) TCS or topical calcineurin inhibitors (TCI). Crisaborole is not marketed in Denmark and thus not recommended. For moderate-to-severe AD, recommendations are treatment with potent (e.g., betamethasone) TCS or TCI, and systemic treatment should be reserved for severe treatment refractory AD cases. Phototherapy is used for mild-to-moderate AD in adults, but only for moderate-to-severe AD in children. Very potent (e.g., clobetasol propionate) TCS are generally not recommended for patients with AD in Denmark. Importantly, systemic corticosteroids are not recommended for treatment of AD in Denmark as standard of care, but may be considered for acute and severe flares in special circumstances. During the current study period, dupilumab was not marketed in Denmark.
Denmark has a long tradition of registry-based research due to the availability of nationwide administrative and healthcare registry data . At birth or migration, all Danish residents are assigned a unique, permanent, and unambiguous ten-digit personal identification number that is used across a myriad of registries and databases to enable cross-linkage at individual level. This number serves as the foundation for the Civil Registration System , which contains information such as date of birth, sex, migration, and date of death. All inpatient and outpatient hospital diagnoses are recorded according to the Tenth Revision of the International Classification of Diseases (ICD-10) in the National Patient Registry . Hospital-based use of systemic drugs, biologics, and phototherapy treatments (during admission or from outpatient hospital clinics) is also recorded in this registry as treatment procedure codes. Treatments in primary (e.g., general practitioners) and secondary care (e.g., private dermatologists), e.g., phototherapy at private dermatologists, are recorded in the Health Care Statistics Registry . The Danish National Prescription Registry contains complete information from 1 January 1995 and onwards on all prescriptions dispensed to Danish residents at community pharmacies . Registered drugs are categorized according to the Anatomical Therapeutic Chemical classification, a hierarchical classification developed by the World Health Organization for purposes of drug use statistics.
Approval from an ethics committee is not required for register studies in Denmark (Danish law: Lov om videnskabsetisk behandling af sundhedsvidenskabelige forskningsprojekter, § 14, stk. 2).
We obtained treatment data for all patients, aged 0–100 years, consulting with a first-time AD diagnosis at a hospital dermatology clinic in Denmark during the period from 1 January 2005 to 31 December 2012. The diagnostic code for AD has previously been validated with a positive predictive value of 95% (98% in children and 92% in adults, respectively) . Data from each patient was used from 1 year prior to the date on which the patient is diagnosed with AD at the dermatology clinic through to 5 years after the time of diagnosis (i.e., up to 31 December 2017 if a patient was enrolled on 31 December 2012). Patients were followed from the date of their first AD hospital diagnosis (the “index” date, i.e., first hospital visit) occurring from 1 January 2005 to 31 December 2012. Data 1 year prior and 5 years after follow-up were displayed graphically and in tables. Data were extracted in 3-month increments during the observation period. Since clinical measurements of AD severity are lacking in large-scale administrative databases such as the ones used in this study, we performed analyses where AD was presumed to be severe if patients received treatment with systemic drugs used for AD. We presented comorbidity burden by use of the Charlson Comorbidity Index, which allows for a comparison of comorbidities between patients with AD and other disease groups on the basis of risk for mortality or resource use as previously described . As this was a descriptive cohort study, we presented results as means with standard deviations (SDs) for normally distributed continuous variables and medians with interquartile ranges (IQRs) for non-normally distributed continuous variables. Count variables were presented as means with percentages and the proportions over time were displayed graphically. All analyses were performed using SAS statistical software version 9.4 (SAS Institute Inc. Cary, NC, USA) and STATA software version 13.0 (StataCorp, College Station, TX, USA).
In total, 8213 people with a first-time hospital dermatologist contact for AD were included in the study between 1 January 2005 and 31 December 2012 (3514 aged 0–9 years, 1501 aged 10–19 years, 3198 aged 20 years or older). The median (IQR) age was 15.5 (3.3–30.7), and there was a female predominance (55.5%; Table 1). The differences in sex distribution were most pronounced among people aged 20–29 (30.5% male), and 30–39 (35.2% male), respectively. The vast majority (88.3%) were of Danish ethnicity; however, among the youngest age group (0–9 years when first presenting at the hospital with AD), 8.6% were of Asian ethnicity, and 4.3% were of African ethnicity (Table 1), which is somewhat higher than the distribution of these ethnicities in the general population in Denmark .
At baseline, a history of moderately potent TCS was seen among 46.6% of children (0–9 years), whereas a history of potent or very potent TCS use was seen more frequently among older individuals. For example, 51.1% and 25.6% of people aged 50 years or older had used potent and very potent TCS, respectively (Table 1). Overall, in the entire population (0–100 years) the prevalence of comorbidity (from the Charlson Comorbidity Index ) at baseline was low (all comorbidities had a prevalence of less than 2%, with the exception of chronic pulmonary disease, 15.1%). This was predominantly driven by the presence of asthma, as also seen in Table 1.
Healthcare consumption was overall highest in the year preceding and the year immediately after first AD hospital diagnosis (Table 2 and Figs. 1, 2). The median (interquartile range) annual number of visits to general practitioners at baseline was 4 (2–7) and 5 (2–8) for children and adults, respectively. Three years later, these numbers had decreased to 2 (1–4) and 3 (1–6), respectively. Among topical therapies, the most frequently used treatment modalities when presenting to the hospital were potent and moderately potent TCS (Fig. 1a). Notably, use of topical antibiotics (alone or in combination with TCS) increased in the last 3–6 months prior to the hospital visit, and decreased thereafter (Fig. 1a), and use of systemic corticosteroids increased dramatically in the months preceding the initial hospital visit, after which the use decreased considerably (Fig. 1b). Use of systemic dicloxacillin (i.e., the preferred oral antibiotic for treatment Staphylococcus aureus in Denmark) increased dramatically in the last months prior to first hospital visit (Fig. 2a) whereas no major change was observed for systemic antiviral therapies (Fig. 2a). Use of other systemic treatments, in particular azathioprine and phototherapy, increased noticeably around the time of first hospital visit (Fig. 1b) albeit the use of these drugs was generally very low.
Most frequently, patients received monotherapy with potent or moderately potent TCS (Fig. 2b), and when stratified by disease severity, patients classified as having mild disease (i.e., those never treated with systemic therapies) most frequently used moderately potent TCS followed by potent TCS (Fig. 2c), whereas patients classified as having severe disease (i.e., those at some point receiving systemic treatment) most frequently used potent TCS followed by moderately potent TCS (Fig. 2d). Data presented in 3-month increments are available from Table 3.
In this longitudinal cohort study of patients with AD in Denmark, the most frequently prescribed systemic therapies in the months immediately prior to first hospital dermatologist visit were systemic corticosteroids and dicloxacillin. Approximately one-third of patients were prescribed a potent or moderately potent TCS when referred for hospital-based treatment, and very few patients were treated with systemic therapies. These findings suggest either a considerable undertreatment among patients with AD in Denmark or that patients are mainly referred for treatment of a single severe flare that quickly resolved. Regardless, our findings highlight considerable differences in treatment patterns between general practitioners and private practice dermatologists, compared with hospital-based dermatologists.
The dramatic increase in use of topical or systemic antibiotics and systemic corticosteroids in the last 3–6 months prior to the first hospital referral could suggest that many such hospital referrals are driven in part by uncontrolled disease with frequent skin infections, requiring more intensified or specialized treatment and proper education in how to manage their AD. Notably, however, the spike in use of systemic corticosteroids, followed by a steep decline in such prescriptions after referral, shows a clear divergence from national guidelines which do not recommend use of systemic corticosteroids as a standard treatment of AD, but recommend that this is reserved for special cases of severe uncontrollable flares . Again, this could also represent a need for further educational efforts of general practitioners and private practice dermatologists to ensure that novel treatment guidelines and recommendations are correctly applied. The overall very low prevalence of systemic therapy in our study is supported by previous studies from Denmark, where only 7% of patients with severe AD received systemic therapy [22, 23]. Notably, the AD diagnosis has been validated in children and adults with very high positive predictive values in the Danish registries, thus ensuring that patients indeed had AD at the time of their referral . A novel finding, however, is the somewhat low use of potent TCS, which could either be a sign of general undertreatment across therapies or due to steroid-phobia among patients . Nonetheless, the low use of established AD therapies is in stark contrast to the high symptom burden and need for disease resolution that is reported among patients with AD [6, 22]. Notably, the Danish healthcare system provides partial reimbursement of pharmacy-filled prescriptions, including those for topical therapies, and systemic treatments given from hospital clinics (e.g., dupilumab and methotrexate) are provided without the need for co-payment, which therefore should enable a greater access to appropriate therapies to better manage patients’ AD. Taken together, these findings suggest that further efforts are needed to heighten the adherence to evidence- and consensus-based treatment guidelines and defined treatment targets, and to provide more optimal care for patients with AD.
Certain limitations apply to the interpretation of the present findings. The study inclusion period was between 2005 and 2012, i.e., before dupilumab was available for treatment of AD. With the advent and introduction of more potent therapies and the subsequent increased disease awareness, it is possible that treatment patterns will change. However, very recent data still suggest that patients with AD in Denmark are markedly undertreated . In the present study we lacked clinical information on disease severity; however, even among patients treated with systemics, i.e., arguably the most severe patients, use of either mono- or combination therapy was very limited, thus highlighting the robustness of our initial findings. Moreover, we lacked data on use of emollients, as such information is not recorded in our data sources. The study was limited to patients that were eventually referred for hospital-based dermatology treatment, and whether the findings also applies to other patient segments such as those only ever seen by private practice dermatologists or general practitioners remains unclear. Lastly, since these data were based on patients seen in the Danish healthcare system, extrapolation to other countries should be done with caution.
In conclusion, we found that a proportion of patients with AD were treated with antibiotics (topical or systemic) and systemic corticosteroids prior to being referred for hospital-based dermatologist treatment. Generally, low proportions of patients received systemic or even potent topical therapy, suggesting that many patients may still be undertreated or that many patients only experience brief flares that quickly resolve. These findings highlight considerable differences in treatment patterns between general practitioners and private practice dermatologists, compared with hospital-based dermatologists, and emphasize the need for better adherence to evidence-based treatment guidelines.
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The study and the journal’s rapid service fee was supported by Eli Lilly and Company.
All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.
Dr. Alexander Egeberg has received research funding from Pfizer, Eli Lilly, the Danish National Psoriasis Foundation, and the Kgl Hofbundtmager Aage Bang Foundation, and honoraria as consultant and/or speaker from AbbVie, Almirall, Leo Pharma, Samsung Bioepis Co., Ltd., Pfizer, UCB, Eli Lilly and Company, Novartis, Galderma, Dermavant, Bristol-Myers Squibb, and Janssen Pharmaceuticals. Dr. Jacob Thyssen has attended advisory boards for Eli Lilly & Co, Pfizer, Abbvie, LEO Pharma, and Sanofi-Genzyme; received speaker honorarium from LEO Pharma, Regeneron, Abbvie and Sanofi-Genzyme and been an investigator for LEO Pharma, Eli Lilly & Co, Abbvie, Pfizer, and Sanofi-Genzyme. Dr. Jashin Wu is or has been an investigator, consultant, or speaker for AbbVie, Almirall, Amgen, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Dermavant, Dermira, Dr. Reddy’s Laboratories, Eli Lilly, Janssen, LEO Pharma, Novartis, Regeneron, Sanofi Genzyme, Sun Pharmaceutical, UCB, Valeant Pharmaceuticals North America LLC. Drs. Evangeline Pierce and Jorge Terres are currently employed by Eli Lilly and Company.
Compliance with Ethics Guidelines
Approval from an ethics committee is not required for register studies in Denmark (Danish law: Lov om videnskabsetisk behandling af sundhedsvidenskabelige forskningsprojekter, § 14, stk. 2).
The datasets generated during and/or analyzed during the current study are not publicly available due to Danish law. The repository can only be accessed by authorized researchers.
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Cite this article
Egeberg, A., Thyssen, J.P., Wu, J.J. et al. Treatment Patterns in Danish Patients with Atopic Dermatitis Before and After Hospital Referral. Dermatol Ther (Heidelb) 11, 499–512 (2021). https://doi.org/10.1007/s13555-021-00491-2
- Atopic dermatitis
- Atopic eczema
- Treatment patterns