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Scoping Review on the Use of Drugs Targeting JAK/STAT Pathway in Atopic Dermatitis, Vitiligo, and Alopecia Areata

Dermatology and Therapy volume 9, pages 655–683 (2019)Cite this article

Abstract

Introduction

The JAK/STAT signaling pathway is involved in the immune-mediated inflammatory skin diseases atopic dermatitis (AD), vitiligo, and alopecia areata (AA), and represents a potential target when developing treatments. So far, no drugs targeting this pathway have been approved for the treatment of dermatological diseases. We reviewed the use of drugs blocking the JAK/STAT pathway in the aforementioned diseases.

Methods

An a priori protocol was published. We used Joanna Briggs Institute Reviewer’s Manual methodology to conduct the review and PRISMA Extension for Scoping Review (PRISMA-ScR) to report results. MEDLINE, EMBASE, CINAHL, Scopus, and Web of Science databases were searched in a three-step approach on April 2019 by two researchers.

Results

Ninety-six mainly multicenter observational studies were included (66, 10, and 20 studies on AA, vitiligo, and AD, respectively). Tofacitinib and ruxolitinib were mainly used for the three diseases, and also upadacitinib, abrocitinib, baricitinib, cerdulatinib, delgocitinib, gusacitinib for AD, and baricitinib, PF-06700841, and PF-06651600 for AA. All patients with AD improved, whereas patients with vitiligo and patients with AA showed varied responses, including unresponsive cases. The safety profiles were similar for all drugs and diseases, mainly comprising mild or no adverse events.

Conclusions

Evidence on the efficacy and safety of drugs targeting the JAK/STAT pathway for the treatment of patients with AD, vitiligo, or AA is increasing but is still of low quality.

Introduction

Immune-mediated inflammatory skin diseases are a group of frequently associated disorders comprising atopic dermatitis (AD), vitiligo, and alopecia areata (AA), among others. AD is a chronic inflammatory skin disease associated with skin barrier dysfunction, intense pruritus, and eczematous skin lesions. Its estimated prevalence in industrialized countries is 15–30% in the pediatric population and 2–10% in the adult group [1]. Vitiligo is a chronic autoimmune disorder characterized by cutaneous depigmentation as a result of the destruction of melanocytes via cell-mediated immunity, affecting 1–2% of the population worldwide including children and adults [2]. AA is a multifactorial autoimmune disease in which an immune-mediated destruction of hair follicles in conjunction with genetic predisposition lead to non-scarring hair loss, typified by alopecic patches that can encompass the entire scalp in alopecia totalis or body in alopecia universalis [3]. It is one of the most prevalent autoimmune diseases with approximately 2% lifetime risk [4, 5].

These three diseases cause significant impairment in the quality of life of the patient and marked psychological distress derived from their associated symptoms and the stigma related to a highly visible skin condition [6,7,8]. This profound impact is not completely avoidable because the currently existing therapies are limited in efficacy and not exempt from undesirable side effects, which is the reason behind performing further research.

Since multiple molecules are involved in their pathogenesis, further knowledge of molecular cell biology has permitted the design of new drugs directed against key targets in signaling pathway regulation. In this sense, the Janus kinases (JAKs) and signal transducer and activator of transcription (STAT) proteins (JAK/STAT) pathway is one of a handful of pleiotropic routes used to transduce multiple extracellular signals involved in cell proliferation, differentiation, migration, and apoptosis [9]. The JAK pathways are believed to play an important role in inflammatory processes as they are involved in signaling for over 50 cytokines and growth factors, many of which drive immune-mediated conditions.

The JAK family is constituted by four types of cytoplasmic tyrosine kinases: JAK1, JAK2, JAK3, and TYK2 [10]. STAT, of which there are seven different subtypes (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6), is the other fundamental component of the cascade [11]. After being phosphorylated by JAK, STAT translocates to the nucleus to induce the transcription of specific genes (Fig. S1 of Supplementary Material). Alterations in the JAK/STAT pathway have been related to the pathophysiology of AD, vitiligo, and AA. In fact, some molecules, such as interleukins (IL)-2 and its family, IL-23, interferon alpha [12], and IL-17 [13], have demonstrated their importance in the development of dermatological diseases by direct or indirect regulation of this pathway. Therefore, drugs that act on this pathway [14] by selectively inhibiting one (filgotinib, JAK1; pacritinib, JAK2; decernotinib, JAK3) or more than one (tofacitinib, JAK1 and JAK3; ruxolitinib, baricitinib, JAK1 and JAK2) JAK protein [15] are promising for the treatment of the aforementioned diseases [14] (Table S7 of Supplementary Material).

So far, no JAK/STAT inhibitors have been approved for the treatment of dermatological diseases, although some of them (ruxolitinib and tofacitinib) are used in other illnesses, such as myelofibrosis and rheumatoid arthritis [16, 17]. However, the off-label use of these drugs showed promising results in the treatment of different skin diseases, including AA, AD, and vitiligo. Broadening our knowledge on the efficacy and safety profiles of these drugs and their application in dermatological diseases is essential to establish their risk–benefit balance.

A scoping review is a form of scientific methodology that addresses an exploratory research question, with the aim of mapping key concepts and gaps related to a defined area or field [18]. The development of JAK inhibitors for the treatment of AA, AD, and vitiligo is still in its early stages. In order to avoid the extensive efforts that would be needed to conduct studies aimed at answering specific questions, we considered it necessary to review the literature available to date. Therefore, we performed a scoping review to broadly summarize all the available evidence presented to date on the use of inhibitors of the JAK/STAT pathway in the treatment of AA, AD, and vitiligo diseases.

Methods

Protocol and Registration

We conducted this scoping review in accordance with the recently published a priori protocol [19]. Methodology to conduct scoping reviews by the Joanna Briggs Institute was followed [20] and results were presented using the recent Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews (PRISMA-ScR) [21].

Literature Search and Eligibility Criteria

Strategies for literature search and eligibility criteria are broadly described in the Supplementary Methods (Supplementary Material).

Data Chart

The relevant information for this review was extracted and summarized in a data chart developed by two reviewers. Characteristics of the studies, including information about author(s), year of publication, country, study design, registration, conflict of interest (COI), and funding, were displayed in separate tables for AA, AD, and vitiligo. Epidemiological aspects of the studies, including a classification based on the type (experimental or observational) and subtype of study, study population, sample size, as well as an evaluation of the efficacy and safety of drugs for each disease (intervention type, details of comparators, duration of the intervention, dosage, outcomes, and adverse events) were collected and displayed in tables. Finally, a table linking randomized clinical trial (RCT) protocols and the subsequently published articles was also created.

Report of Results

Results of the comprehensive search were presented in a PRISMA flow diagram. We organized the extracted data in several categories: indications, mechanism of action, efficacy, and safety and provided a clear explanation for each category. Finally, the results of the scoping review were presented in both diagrammatic and tabular forms, and in a descriptive format, accompanied by a narrative summary of the relation between the results and the review objective and question(s).

Compliance with Ethics Guidelines

This article is based on previously conducted studies and does not contain any studies with human participants or animals performed by any of the authors; thus, no ethical approval from institutional committees was required.

Protocol versus Overview

Our planned search strategy published in BMJ Open was compared with the final reported review methods. No differences were found.

Results

From 2197 articles (EMBASE + MEDLINE 1108; EMBASE 1048; MEDLINE 41) regarding the use of JAK/STAT-targeting drugs in dermatological diseases, after filtering duplicates and selecting studies according to title, abstract, and keywords, 116 studies met the criteria for full-text review (Fig. 1). Of these, 95 articles fulfilled the inclusion criteria and one article was included after reviewing the references of those studies. Thus, 96 studies, which included 66, 20, and 10 reports describing AA, AD, and vitiligo, respectively, were finally analyzed in the scoping review. A reference list of all articles with reasons for inclusion and exclusion is presented in Tables S2 and S3 of Supplementary Material.

Fig. 1
figure 1

PRISMA flow diagram

Full size image

Mapping Studies on Use of JAK Inhibitors

Atopic Dermatitis

Twenty studies [22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41] comprising 1851 patients with AD were published from 2015 to 2019 as full-text publications of abstracts presented at congresses (n = 11) or scientific manuscripts (n = 9) (Tables S4 and S8 of Supplementary Material). Seven studies (35%) previously registered an a priori protocol in a public registry. Sixteen (80%) were multicenter studies involving up to 38 different institutions. The average number of authors and affiliations per article was 7 (range 3–18) and 6 (range 1–38), respectively. Sixteen articles (80%) had at least one author who was working for a pharmaceutical company, with an average of five authors per article (range 0–16). Eight studies (40%) declared that one or more authors had conflicts of interest (CoIs), while another article (5%) denied any CoIs and 11 papers did not mention CoI (55%). Disclosures related to the funding sources were detailed only in seven articles (35%), including public sources (n = 1), pharmaceutical sources (n = 5), or none (n = 1).

Vitiligo

Ten studies [42,43,44,45,46,47,48,49,50,51] comprising 62 patients with vitiligo were published between October 2015 and June 2018 as full manuscripts (n = 7), full-text publications of abstracts presented at congresses (n = 2), or letters (n = 1) (Tables S5 and S8 of Supplementary Material). Only three studies (30%) had an a priori protocol. Six (60%) were multicenter studies with up to four centers participating. The average number of authors and affiliations per article was 5 (range 2–13) and 2 (range 1–4), respectively. Authors from pharmaceutical industries were involved in three studies with an average number of one author (range 1–2). Three studies (30%) declared the existence of an author’s CoI, five articles (50%) declared having no CoI, and in another two (20%) this information was not available. Funding sources were described in five articles (50%) and were divided into public sources (n = 3), both public and pharmaceutical sources (n = 1) ,or none (n = 1).

Alopecia Areata

Sixty-six studies [49, 50, 52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114] comprising 950 patients with AA were published between May 2013 and May 2019 as full papers (n = 39), letters (n = 14), or full-text publications of abstracts presented at congresses (n = 11) (Tables S6 and S8 of Supplementary Material). Of those, 16 studies (24.2%) had previously published or registered an a priori protocol. The majority of studies were performed in the USA (n = 41) and 37 studies (56%) were multicenter involving up to five institutions. The number of authors per article ranged from 1 to 15, with an average of 4. Only 17 studies declared CoIs among their authors, whereas 29 studies stated not to have any, and 20 articles did not make any reference to this topic. Information on funding sources was available in 32 manuscripts, of which 15 were funded by public sources, one by academic and pharmaceutical industry, and 16 did not receive any funding.

Evidence of Efficacy and Safety of Treatment with JAK Inhibitors

Atopic Dermatitis

Twenty studies on the use of JAK inhibitors for the treatment of AD were identified, four of which followed an observational design (two case reports and two case series) and 16 followed an experimental design (three phase I and 13 phase II RCTs) (Table 1). The duration of observational studies ranged from 6 to 10 months. The phase I RCT study was performed for 7 days and phase II RCTs lasted for 4–16 weeks. The reviewed articles explored the efficacy and safety of a wide variety of drugs such as tofacitinib (three systemic, three topical), upadacitinib (five systemic), ruxolitinib (three topical), abrocitinib (two systemic), gusacitinib (one systemic), delgocitinib (one topical), baricitinib (one systemic), and cerdulatinib (one topical). Efficacy outcomes were assessed using several validated scales, such as Eczema Area and Severity Index (EASI), pruritus Numerical Rating Scale (NRS) score, Investigator’s Global Assessment (IGA), body surface area (BSA), Severity Scoring of Atopic Dermatitis Index (SCORAD), or Patient-Oriented Eczema Measure (POEM).

Table 1 Characteristics of primary clinical studies on atopic dermatitis
Full size table

Significant improvement across all efficacy endpoints was evidenced in both experimental and observational studies. Furthermore, some studies evaluated relapse rate after a treatment discontinuation. Most studies did not report adverse events. Where they were reported, the majority were mild cases of upper respiratory tract infections, nasopharyngitis, AD exacerbation, erysipelas, headache, nausea, diarrhea, white cell count decrease (neutropenia, lymphopenia), or mild hypertension. There were four reports of severe adverse events: herpes zoster-associated encephalitis, appendicitis, pericoronitis, and skin infection.

Vitiligo

We identified ten studies about the use of JAK inhibitor drugs in vitiligo therapy. Seven of them were observational (four case reports, three case series), whereas three were open-label experimental studies (Table 2). Study length ranged from 3 to 10 months for observational studies and from 5 to 13 months for experimental studies. Regarding drug and administration route, seven articles were about tofacitinib (three systemic, one topical, three systemic/topical) and three were about ruxolitinib (two topical, one systemic). Seven studies (five observational, two experimental) set the percentage change in repigmentation (or percentage decrease in BSA) as their primary endpoint. Out of 17 patients in whom facial repigmentation was specifically studied, 14 (82%) showed different degrees of response. Concerning body repigmentation, which was assessed in 27 patients, 13 (48%) of them had an improvement; meanwhile, five patients experienced preferential repigmentation in sun-exposed areas. Three studies (one observational, two experimental) considered the improvement in Vitiligo Area Scoring Index (VASI) score as their main goal. These studies found that from a total of 20 patients, 14 (70%) had some improvement in VASI score, although with varied degrees, and one patient only showed a marginal improvement. Overall, 14 out of 20 patients (70%) responded to ruxolitinib and 11 out of 16 (68%) to tofacitinib.

Table 2 Characteristics of primary clinical studies on vitiligo
Full size table

Adverse events, though infrequent and mild, included application-site irritation, folliculitis, hypertension, upper respiratory tract infections, herpes zoster infection, increased appetite, weight gain, or diarrhea.

Alopecia Areata

Sixty-six studies on drugs targeting the JAK/STAT pathway in AA were selected (Table 3). Most of them followed an observational design (30 case reports and 23 case series). There were also 13 experimental studies (7 open-label, 1 phase I, 5 phase II RCTs). Both observational and experimental studies lasted between 3 months and 3 years. Most manuscripts focused on the treatment with tofacitinib (41 systemic, 3 topical), ruxolitinib (9 systemic, 2 topical), or both tofacitinib vs ruxolitinib (4, both as topical and/or systemic). Two studies were found for baricitinib (systemic) and for both PF-06700841 and PF-06651600, two dual TYK2/JAK1 and JAK3/TYK2 family kinase inhibitors, respectively.

Table 3 Characteristics of primary clinical studies on alopecia areata
Full size table

Efficacy outcomes were mainly measured by using Severity of Alopecia Tool (SALT) score in experimental studies, while the percentage of hair regrowth, at least 50% regrowth achievement, or HRQoL assessed by Skindex-16 scores were used to determine treatment efficacy in observational studies. Hair regrowth was observed in around 50% of patients, with some studies finding at least 50% hair regrowth. Some studies found a median frequency of hair regrowth of 50.5% (2–90%), and a mean response time of 4.2 (range 1–9) months. In some cases, relapse was observed after drug withdrawal. JAK inhibitors were generally safe and well tolerated in all AA studies. Reported adverse events included minor bacterial skin infections, peripheral edema, acneiform eruptions, upper respiratory or urinary tract infections, viral infections, tonsillitis, allergy, pneumonia, conjunctival hemorrhage, mild gastrointestinal symptoms, lipid and liver abnormalities, mild anemia, headache, fatigue, increased appetite, weight gain, and one case of leukopenia.

Discussion

Summary of Findings

This is the first scoping review which summarizes the available evidence on the use of JAK inhibitor drugs in patients with AD, vitiligo, and AA. Our results provide more insight about the gap that exists between specific therapeutical needs not covered by current therapies and the strategical value of these diseases in the R&D pipeline of pharmaceutical companies.

Some patterns were found after systematically reviewing evidence of using JAK-targeting drugs for AD, vitiligo, and AA. Most reviewed studies were related to AA disease, and just a few published studies about vitiligo were identified. In both cases, studies followed an observational design, mostly as small case series. Also, they mainly used systemic drugs, with tofacitinib followed by ruxolitinib, as the JAK inhibitors most frequently used. Although there are some planned or ongoing early phase RCTs for AA, no vitiligo study was associated with any current or completed RCT. Response to treatment was very variable among studies. In most vitiligo studies a positive therapeutic response was noted in 50% of patients, especially in sun-exposed areas. However, not standardized methods were used to assess the efficacy, and the period of follow-up was less than 6 months in most cases. In AA studies, a validated scale (SALT) was frequently used and the follow-up period was longer than in vitiligo studies. We noted two observations of JAK inhibitor response in many AA studies: first, many patients that achieved therapeutic efficacy needed to scale up or maintain treatment for an extended period of time; secondly, in many of these cases the achieved effect was lost after treatment was discontinued. As we observed different responses with different agents in different diseases, we shall consider selecting some specific types of JAK/STAT in different diseases on the basis of their pathogenic features. Finally, the number of published AD studies was intermediate between vitiligo and AA and mostly were associated with phase I/II RCTs, involving up to seven drugs/pharma companies and enrolling a total of 2098 patients. Improved methodological procedures were implemented (i.e., using several standardized tools for each study) to assess efficacy and safety outcomes more rigorously in AD studies as compared to those used for AA and vitiligo. Studies were mainly multicenter and multidisciplinary, especially related to AA, as they involved the largest number of medical specialties and were performed in a higher number of countries, most of them developed countries and mainly represented by the USA. Private funding sources were scarce, and most studies received financial support either from public sources or from none. Conflicts of interest were minimal.

Some factors may explain differences between clinical needs and pharma initiatives: prevalence, burden of disease, and current therapeutic options. The prevalence of vitiligo and AA is lower than that of AD. The burden of disease is higher for AD and AA, compared to that of vitiligo. Therapeutic options are not specifically targeted in any of the three cases. However, there are more current therapeutic options for AD as compared to those for AA and vitiligo. These facts could explain why most the pharmaceutical industry is more interested in developing clinical trials to assess targeted therapies with different drugs in the case of AD, as compared to AA and vitiligo. The increased burden of disease associated with AA could explain the great number of physician-initiated off-label observational studies.

Strengths and Limitations

Some years ago, a systematic review was published about the available data on the use of JAK inhibitors in cutaneous diseases [115]. Recently, two systematic reviews about JAK inhibitors were published, both of them focused on patients with AA and included 30 studies [116, 117]. After assessing these reviews using A MeaSurement Tool to Assess systematic Reviews (AMSTAR) 2 instrument [118], we found that the overall confidence in their results was critically low (data not shown). These reviews had more than one critical flaw and did not provide an accurate and comprehensive summary of the available studies. There are also some non-systematic reviews or literature reviews about JAK inhibitors for AA, AD, and vitiligo, all of them with an intrinsic lower methodological quality as compared with systematic reviews [119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134].

In contrast to all the above, our review was conducted systematically according to the methodology planned in an a priori protocol published prior to study performance. This methodology followed the latest guidelines for conducting scoping reviews and at least two researchers participated in each of the phases. Authors were contacted to clarify certain details about primary data when necessary. Reporting was based on recommendations from the PRISMA Extension for Scoping Reviews. However, funding and time limitations only allowed for the inclusion of studies published in English in our analysis. Even though we believe that the literature search was complete and the performance of a three-stage search approach minimized the potential loss of relevant papers, there is still a possibility that we missed some manuscripts. Additionally, it was not possible to obtain all missing data or clarification of poorly detailed data from some articles we reviewed, even after contacting the authors. This was especially relevant in studies published in the form of abstracts, which we did not exclude. Furthermore, most of these selected studies were of low quality, owing to their observational designs and the high proportion of observational studies and their diversity of efficacy endpoints and outcome reporting forced us to organize and analyze the information into broader and less detailed categories. As a result of the large amount of information extracted from the search and the different designs of the included studies we were not able to do analysis comprising individual patients. Finally, we did not assess the quality of the studies included here, in terms of risk of bias, quality of evidence, and statistical analysis techniques.

Research Gaps

The small number of studies about the use of drugs targeting the JAK/STAT pathway in the treatment of AD and vitiligo contrasts with the great amount of available information on the use of these drugs in AA. Most of the reviewed studies were observational, which translated into a low quality of evidence, according to the GRADE system for grading the quality of evidence [117]. In addition to this, the absence of an a priori design published in a public repository, as occurs in the majority of included studies, could increase the bias risk and reduce analysis transparency, thus limiting the validity and reproducibility of results. Therefore, future studies should focus on improving study quality in order to achieve reliable evidence that could be applicable to clinical practice.

Considering these limitations, the use of JAK inhibitors for the treatment of AD, vitiligo, and AA is promising. The conditions of most participants with AD improved to some extent, while in vitiligo and AA studies both responders and non-responders were identified. Given the preferential repigmentation in sun-exposed areas that some patients with vitiligo experienced when treated with JAK inhibitors, the concomitant or sequential treatment of these patients with UV exposure and these drugs may result in a greater improvement compared to administration of the drug. Response rates to tofacitinib and ruxolitinib were similar in all the studied diseases, while efficacy evidence for other drugs (upadacitinib, baricitinib, cerdulatinib, abroticinib, delgocitinib, and gusacitinib) was scarce because of the small number of studies in which they were applied. It is imperative to establish a consensus on the best methodology (outcomes, validated scales, and time point for assessment) to measure efficacy, which will allow comparison of results between studies, especially in the case of vitiligo and AA, and AD to a lesser extent. Overall, JAK inhibitor drugs have shown short-term acceptable safety, even though they are not completely without adverse events. However, further phase III/IV RCTs are required to ensure more accurate efficacy and safety profiles of these drugs. In fact, there are currently several protocols of RCTs registered in ClinicalTrials.gov about JAK inhibitors for AA, AD, and vitiligo treatment, most of them promoted by the industry and still active and recruiting (Table S8 of Supplementary Material).

Conclusions

Evidence on the use of drugs targeting the JAK/STAT pathway for the treatment of dermatological diseases such as AD, vitiligo, and AA is growing but still mainly focused on observational or early phase experimental studies. Although existing results are promising, further studies are needed to ensure that the efficacy and safety parameters of these drugs are optimal for their use in clinical practice. These clinical trials studies should provide more accurate results by improving their design, standardization of scales, and the time of outcome measurement.

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Acknowledgements

Funding

This work was supported, in part, by project ICI1400136 to JR, integrated into the National Plan of R+D+I 2008-2011 and cofinanced by the ISCIII-Subdirección General de Evaluación and European Regional Development Fund (ERDF), by project PIN-0316-2017 of the Consejería de Salud, Junta de Andalucía (Spain) to JR, and by Grant PP13/009 of Plan Propio de movilidad para investigadores del Instituto Maimonides de Investigacion Biomédica de Córdoba (IMIBIC). No funding was received from any pharmaceutical company. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Authorship

All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. The authors would like to thank Editage (http://www.editage.com) for English-language editing.

Authorship Contributions

Ana M. Montilla and Francisco Gómez-García contributed equally to this work.

Disclosures

Juan Ruano is a member of the journal’s Editorial Board. Ana M. Montilla, Francisco Gómez-García, Pedro J. Gómez-Arias, Jesús Gay-Mimbrera, Jorge Hernández-Parada, Beatriz Isla-Tejera have nothing to disclose.

Compliance with Ethics Guidelines

This article is based on previously conducted studies and does not contain any studies with human participants or animals performed by any of the authors.

Data Availability

All data generated or analyzed during this study are included in this published article or as supplementary information file.

Open Access

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Authors and Affiliations

  1. Immune-mediated Inflammatory Skin Diseases Group, IMIBIC/Reina Sofía University Hospital/University of Córdoba, 14004, Córdoba, Spain

    Ana M. Montilla, Francisco Gómez-García, Pedro J. Gómez-Arias, Jesús Gay-Mimbrera, Beatriz Isla-Tejera & Juan Ruano

  2. Department of Dermatology, Reina Sofía University Hospital, 14004, Córdoba, Spain

    Francisco Gómez-García, Pedro J. Gómez-Arias & Juan Ruano

  3. School of Medicine, University of Córdoba, 14004, Córdoba, Spain

    Ana M. Montilla

  4. Department of Pharmacy, Reina Sofía University Hospital, 14004, Córdoba, Spain

    Jorge Hernández-Parada & Beatriz Isla-Tejera

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  5. Jorge Hernández-Parada
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Correspondence to Juan Ruano.

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Montilla, A.M., Gómez-García, F., Gómez-Arias, P.J. et al. Scoping Review on the Use of Drugs Targeting JAK/STAT Pathway in Atopic Dermatitis, Vitiligo, and Alopecia Areata. Dermatol Ther (Heidelb) 9, 655–683 (2019). https://doi.org/10.1007/s13555-019-00329-y

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  • DOI: https://doi.org/10.1007/s13555-019-00329-y

Keywords

  • Alopecia areata
  • Atopic dermatitis
  • Baricitinib
  • Cerdulatinib
  • Immune-mediated inflammatory skin diseases
  • JAK/STAT pathway
  • Ruxolitinib
  • Tofacitinib
  • Upadacitinib
  • Vitiligo