Scrotal rejuvenation encompasses not only the functional quality but also the aesthetic appearance of the scrotum. It includes medical therapy and procedural interventions to improve scrotal conditions that require morphologic restoration and/or aesthetic alteration. Rejuvenation of the scrotum may be appropriate for aging-related and non-aging-related changes concerning the hair (alopecia and hypertrichosis), the morphology (laxity and wrinkles), and/or the vascularity (angiokeratoma) of the scrotum. Angiokeratomas—typically small, asymptomatic, purple papules—may occur on the scrotum. However, these benign vascular lesions may be of cosmetic concern to the affected individuals; in addition, the angiokeratomas can become an issue of medical importance if they begin to bleed. Multiple locally destructive modalities are available for the treatment of scrotal angiokeratomas; indeed, several lasers have effectively been used to treat angiokeratomas of the scrotum. A 70-year-old man with numerous scrotal angiokeratomas experienced scrotal bleeding in the absence of prior trauma to the area or sexual activity. He presented for treatment to prevent future episodes of spontaneous bleeding from his scrotal angiokeratomas, but he also had not liked the aesthetic appearance of the previously asymptomatic angiokeratomas on his scrotum. His angiokeratomas were successfully treated with three sequential 532-nm potassium titanyl phosphate (KTP) laser sessions, which led to not only functional but also cosmetic improvement of his scrotum. In conclusion, men can develop scrotal changes due to either intrinsic (aging) or extrinsic (trauma) causes, but nonsurgical interventions and surgical procedures are available for the management of these conditions in individuals who desire to rejuvenate their scrotum.
Scrotal rejuvenation refers to medical and cosmetic conditions of the scrotum that can appear with aging and may be amenable to medical treatment and/or surgical intervention . Angiokeratomas of the scrotum present as small purple to red papules that are usually asymptomatic, although spontaneous bleeding occurs in some men [2,3,4,5,6,7]. A man with bleeding scrotal angiokeratomas that were successfully treated with only a 532-nm potassium titanyl phosphate (KTP) laser is described here. While the lesions had previously been asymptomatic, he did not like their aesthetic appearance on his scrotum but had not realized that there were potential interventions that could be used to resolve the angiokeratomas. To the author’s knowledge, this is the first case report of a 532-nm KTP laser being used as monotherapy for this purpose. Informed consent was obtained from the participant for inclusion in the study. The patient also signed a consent form providing permission to include relevant clinical photographs in this article.
A 70-year-old man presented for evaluation of multiple lesions that had been present on his scrotum for more than three decades. The lesions had been asymptomatic, but he was unhappy with their appearance. Earlier that day, one of the lesions had bled; there had been no prior trauma or sexual activity. He compressed the site and the bleeding ceased.
Cutaneous examination showed more than 50 purple papules 2–3 mm in size on each side of his scrotum (Fig. 1). All of the lesions were painless. There was no evidence of varicocele, testicular tumor, or inguinal hernia. Correlation of the clinical presentation and lesion morphology established a diagnosis of angiokeratomas of the scrotum.
In order to prevent future episodes of spontaneous bleeding, the patient decided to have laser treatment of his scrotal angiokeratomas. A 532-nm KTP frequency-doubled neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (Excel V; Brisbane, CA, USA) was applied in three monthly treatments. The treatment parameters were as follows: wavelength 532 nm, fluence 11 J/cm2, spot size 3 mm, pulse duration 10 ms, cooling 10 ºC, and an endpoint of vessel darkening.
He received 215 pulses during his first treatment. His second and third treatments were performed one and two months after the initial session, respectively. The same parameters were used during the subsequent sessions, during which he received 201 pulses and 225 pulses, respectively. He tolerated the procedure well, with minimal redness or swelling and no bruising.
A follow-up cutaneous examination performed 3 weeks after his third laser treatment showed a significant decrease in both the number and the size of the angiokeratomas on his scrotum (Fig. 2). He was extremely pleased with the cosmetic appearance. He has had no further episodes of scrotal bleeding.
Genital rejuvenation includes vaginal rejuvenation and scrotal rejuvenation . Rejuvenation of the scrotum includes not only the management of vascular lesions (such as angiokeratomas) but also alterations to the hair (alopecia and hypertrichosis) and morphology (laxity and wrinkles) . Medical and surgical interventions can be used to potentially treat these conditions of the scrotum [1, 8].
Angiokeratomas are benign vascular lesions (Table 1) [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31]. The incidence of scrotal angiokeratomas remains to be determined. Local destructive methods, including lasers (Table 2) [13, 14, 22,23,24,25,26,27,28,29,30,31], have traditionally been used to treat angiokeratoma of the scrotum [1,2,3,4, 6, 12,13,14, 21,22,23,24,25,26,27,28,29,30,31].
The reported patient had not been pleased with the aesthetic appearance of the angiokeratomas on his scrotum, but was unaware that cosmetic intervention to remove angiokeratomas was available. Indeed, his scrotal angiokeratomas were successfully treated with a 532-nm KTP frequency-doubled Nd:YAG laser. The 532-nm wavelength is produced by placing a KTP crystal in the path of a 1064-nm Nd:YAG laser beam, which results in a frequency-doubled 532-nm wavelength, which is absorbed well by oxyhemoglobin. The laser allows contact cooling through a sapphire window [22, 32].
The 532-nm KTP laser has been used in the management of acne vulgaris , rosacea , and skin rejuvenation . In addition, the 532-nm KTP laser has been used to treat angiokeratomas of not only the scrotum (in combination with a 10,600-nm ablative carbon dioxide laser to remove the epidermal hyperkeratosis) , but also the glans penis (in combination with a 2,940-nm ablative Er:YAG laser to eliminate hyperkeratosis of the epidermis) . Finally, the 532-nm KTP laser has successfully treated nongenital angiokeratoma  and other vascular lesions [32, 34, 38,39,40,41].
Scrotal rejuvenation may be appropriate not only for aesthetic concerns but also for conditions that may require functional restoration. Changes that are either aging-related or non-aging-related may result in issues concerning the hair, the morphology, and/or the vascularity of the scrotum. Medical therapy and procedural interventions may be appropriate for men desiring rejuvenation of their scrotum.
Angiokeratomas are benign vascular lesions. Although they are usually asymptomatic, they may be of either cosmetic concern and/or medical importance (if bleeding) to affected individuals. Several lasers have effectively been used to treat angiokeratomas of the scrotum.
Successful management of a man’s spontaneously bleeding scrotal angiokeratomas with three sequential 532-nm KTP laser treatments provided not only functional but also aesthetic improvement of his scrotum. To the author’s knowledge, this is the first case report of a 532-nm KTP laser being used as monotherapy for this purpose. Based on this case report of the clinical success of using the 532-nm KTP laser to treat angiokeratomas of the scrotum and the patient’s satisfaction, it is reasonable to suggest that this laser may have potential for the treatment of men with either bleeding or asymptomatic scrotal angiokeratomas.
In conclusion, either intrinsic (aging) or extrinsic (trauma) causes can result in men developing scrotal changes. There are nonsurgical interventions and surgical procedures available for the management of the conditions associated with these scrotal changes for men who desire to rejuvenate their scrotum.
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I thank the participant in the study.
No funding or sponsorship was received for this study. The article processing charges were waived by the journal for the publication of this article.
All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. The author is fully responsible for all content and received no financial support or any other form of compensation related to the development of this manuscript.
Philip R. Cohen has nothing to disclose with regards to the publication of this article.
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Informed consent was obtained from the participant for their inclusion in the study. The patient also signed a consent form providing permission to include clinical photographs in this article.
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Cohen, P.R. A Case Report of Scrotal Rejuvenation: Laser Treatment of Angiokeratomas of the Scrotum. Dermatol Ther (Heidelb) 9, 185–192 (2019). https://doi.org/10.1007/s13555-018-0272-z