CDC. Get Smart about Antibiotics Week [Internet]. Centers for Disease Control and Prevention. 2015 [cited 2016 Feb 28]. Available from: http://www.cdc.gov/media/dpk/2015/dpk-antibiotics-week-2015.html.
McGann P, Snesrud E, Maybank R, Corey B, Ong AC, Clifford R, et al. Escherichia coli harboring MCR-1 and bla
CTX-M on a novel IncF plasmid: first report of MCR-1 in the United States. Antimicrob Agents Chemother. 2016;60(7):4420–1
PubMed
PubMed Central
Article
CAS
Google Scholar
Bowe WP. Antibiotic resistance and acne: where we stand and what the future holds. J Drugs Dermatol. 2014;13(6):s66–70.
PubMed
Google Scholar
White GM. Recent findings in the epidemiologic evidence, classification, and subtypes of acne vulgaris. J Am Acad Dermatol. 1998;39(2 Pt 3):S34–7.
CAS
PubMed
Article
Google Scholar
Goulden V, Stables GI, Cunliffe WJ. Prevalence of facial acne in adults. J Am Acad Dermatol. 1999;41(4):577–80.
CAS
PubMed
Google Scholar
Bhate K, Williams HC. Epidemiology of acne vulgaris. Br J Dermatol. 2013;168(3):474–85.
CAS
PubMed
Article
Google Scholar
Rosen T. Antibiotic resistance: an editorial review with recommendations. J Drugs Dermatol. 2011;10(7):724–33.
PubMed
Google Scholar
Leyden JJ. In vivo antibacterial effects of tretinoin-clindamycin and clindamycin alone on Propionibacterium acnes with varying clindamycin minimum inhibitory. J Drugs Dermatol. 2012;11(12):1434–8.
CAS
PubMed
Google Scholar
Leyden JJ, Preston N, Osborn C, Gottschalk RW. In-vivo effectiveness of adapalene 0.1%/benzoyl peroxide 2.5% gel on antibiotic-sensitive and resistant Propionibacterium acnes. J Clin Aesthet Dermatol. 2011;4(5):22–6.
PubMed
PubMed Central
Google Scholar
Vowels BR, Feingold DS, Sloughfy C, Foglia AN, Konnikov N, Ordoukhanian E, et al. Effects of topical erythromycin on ecology of aerobic cutaneous bacterial flora. Antimicrob Agents Chemother. 1996;40(11):2598–604.
CAS
PubMed
PubMed Central
Google Scholar
Mills O, Thornsberry C, Cardin CW, Smiles KA, Leyden JJ. Bacterial resistance and therapeutic outcome following three months of topical acne therapy with 2% erythromycin gel versus its vehicle. Acta Derm Venereol. 2002;82(4):260–5.
CAS
PubMed
Article
Google Scholar
Gallo RL, Nakatsuji T. Microbial symbiosis with the innate immune defense system of the skin. J Invest Dermatol. 2011;131(10):1974–80.
CAS
PubMed
PubMed Central
Article
Google Scholar
Marples RR, Fulton JE, Leyden J, McGinley KJ. Effect of antibiotics on the nasal flora in acne patients. Arch Dermatol. 1969;99(6):647–51.
CAS
PubMed
Article
Google Scholar
Leyden JJ, Marples RR, Mills OH, Kligman AM. Gram-negative folliculitis—a complication of antibiotic therapy in acne vulgaris. Br J Dermatol. 1973;88(6):533–8.
CAS
PubMed
Article
Google Scholar
Levy RM, Huang EY, Roling D, Leyden JJ, Margolis DJ. Effect of antibiotics on the oropharyngeal flora in patients with acne. Arch Dermatol. 2003;139(4):467–71.
CAS
PubMed
Article
Google Scholar
Margolis DJ, Fanelli M, Kupperman E, Papadopoulos M, Metlay JP, Xie SX, et al. Association of pharyngitis with oral antibiotic use for the treatment of acne: a cross-sectional and prospective cohort study. Arch Dermatol. 2012;148(3):326–32.
PubMed
Article
Google Scholar
Margolis DJ, Bowe WP, Hoffstad O, Berlin JA. Antibiotic treatment of acne may be associated with upper respiratory tract infections. Arch Dermatol. 2005;141(9):1132–6.
CAS
PubMed
Article
Google Scholar
Adams SJ, Cunliffe WJ, Cooke EM. Long-term antibiotic therapy for acne vulgaris: effects on the bowel flora of patients and their relatives. J Invest Dermatol. 1985;85(1):35–7.
CAS
PubMed
Article
Google Scholar
Work Group, Zaenglein AL, Pathy AL, Schlosser BJ, Alikhan A, Baldwin HE, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016;74(5):945–73.e33.
Schaller M, Sebastian M, Ress C, Seidel D, Hennig M. A multicentre, randomized, single-blind, parallel-group study comparing the efficacy and tolerability of benzoyl peroxide 3%/clindamycin 1% with azelaic acid 20% in the topical treatment of mild-to-moderate acne vulgaris. J Eur Acad Dermatol Venereol. 2016;30(6):966–73.
CAS
PubMed
Article
Google Scholar
Eichenfield LF, Alió Sáenz AB. Safety and efficacy of clindamycin phosphate 1.2%-benzoyl peroxide 3% fixed-dose combination gel for the treatment of acne vulgaris: a phase 3, multicenter, randomized, double-blind, active- and vehicle-controlled study. J Drugs Dermatol. 2011;10(12):1382–96.
CAS
PubMed
Google Scholar
Gollnick HPM, Draelos Z, Glenn MJ, Rosoph LA, Kaszuba A, Cornelison R, et al. Adapalene-benzoyl peroxide, a unique fixed-dose combination topical gel for the treatment of acne vulgaris: a transatlantic, randomized, double-blind, controlled study in 1670 patients. Br J Dermatol. 2009;161(5):1180–9.
CAS
PubMed
Article
Google Scholar
Thiboutot D, Pariser DM, Egan N, Flores J, Herndon JH, Kanof NB, et al. Adapalene gel 0.3% for the treatment of acne vulgaris: a multicenter, randomized, double-blind, controlled, phase III trial. J Am Acad Dermatol. 2006;54(2):242–50.
PubMed
Article
Google Scholar
Pariser DM, Thiboutot DM, Clark SD, Jones TM, Liu Y, Graeber M, et al. The efficacy and safety of adapalene gel 0.3% in the treatment of acne vulgaris: a randomized, multicenter, investigator-blinded, controlled comparison study versus adapalene gel 0.1% and vehicle. Cutis. 2005;76(2):145–51.
PubMed
Google Scholar
Tanghetti E, Dhawan S, Green L, Del Rosso J, Draelos Z, Leyden J, et al. Randomized comparison of the safety and efficacy of tazarotene 0.1% cream and adapalene 0.3% gel in the treatment of patients with at least moderate facial acne vulgaris. J Drugs Dermatol. 2010;9(5):549–58.
PubMed
Google Scholar
Shalita A, Miller B, Menter A, Abramovits W, Loven K, Kakita L. Tazarotene cream versus adapalene cream in the treatment of facial acne vulgaris: a multicenter, double-blind, randomized, parallel-group study. J Drugs Dermatol. 2005;4(2):153–8.
CAS
PubMed
Google Scholar
Feldman SR, Werner CP, Alió Saenz AB. The efficacy and tolerability of tazarotene foam, 0.1%, in the treatment of acne vulgaris in 2 multicenter, randomized, vehicle-controlled, double-blind studies. J Drugs Dermatol. 2013;12(4):438–46.
CAS
PubMed
Google Scholar
Eichenfield LF, Jarratt M, Schlessinger J, Kempers S, Manna V, Hwa J, et al. Adapalene 0.1% lotion in the treatment of acne vulgaris: results from two placebo-controlled, multicenter, randomized double-blind, clinical studies. J Drugs Dermatol. 2010;9(6):639–46.
PubMed
Google Scholar
Babaeinejad SH, Fouladi RF. The efficacy, safety, and tolerability of adapalene versus benzoyl peroxide in the treatment of mild acne vulgaris: a randomized trial. J Drugs Dermatol. 2013;12(7):790–4.
CAS
PubMed
Google Scholar
Langner A, Chu A, Goulden V, Ambroziak M. A randomized, single-blind comparison of topical clindamycin + benzoyl peroxide and adapalene in the treatment of mild to moderate facial acne vulgaris. Br J Dermatol. 2008;158(1):122–9.
CAS
PubMed
Article
Google Scholar
Webster G, Cargill DI, Quiring J, Vogelson CT, Slade HB. A combined analysis of 2 randomized clinical studies of tretinoin gel 0.05% for the treatment of acne. Cutis. 2009;83(3):146–54.
PubMed
Google Scholar
Berger R, Barba A, Fleischer A, Leyden JJ, Lucky A, Pariser D, et al. A double-blinded, randomized, vehicle-controlled, multicenter, parallel-group study to assess the safety and efficacy of tretinoin gel microsphere 0.04% in the treatment of acne vulgaris in adults. Cutis. 2007;80(2):152–7.
PubMed
Google Scholar
Tirado-Sánchez A, Ponce-Olivera RM. Efficacy and tolerance of superoxidized solution in the treatment of mild to moderate inflammatory acne. A double-blinded, placebo-controlled, parallel-group, randomized, clinical trial. J Dermatol Treat. 2009;20(5):289–92.
Article
CAS
Google Scholar
Lucky A, Jorizzo JL, Rodriguez D, Jones TM, Stewart DM, Tschen EH, et al. Efficacy and tolerance of adapalene cream 0.1% compared with its cream vehicle for the treatment of acne vulgaris. Cutis. 2001;68(4 Suppl):34–40.
CAS
PubMed
Google Scholar
Cunliffe WJ, Poncet M, Loesche C, Verschoore M. A comparison of the efficacy and tolerability of adapalene 0.1% gel versus tretinoin 0.025% gel in patients with acne vulgaris: a meta-analysis of five randomized trials. Br J Dermatol. 1998;139(Suppl 52):48–56.
CAS
PubMed
Article
Google Scholar
Webster GF. Safety and efficacy of Tretin-X compared with Retin-A in patients with mild-to-severe acne vulgaris. Skinmed. 2006;5(3):114–8.
PubMed
Article
Google Scholar
Shalita AR, Chalker DK, Griffith RF, Herbert AA, Hickman JG, Maloney JM, et al. Tazarotene gel is safe and effective in the treatment of acne vulgaris: a multicenter, double-blind, vehicle-controlled study. Cutis. 1999;63(6):349–54.
CAS
PubMed
Google Scholar
Jackson JM, Fu J-JJ, Almekinder JL. A randomized, investigator-blinded trial to assess the antimicrobial efficacy of a benzoyl peroxide 5%/clindamycin phosphate 1% gel compared with a clindamycin phosphate 1.2%/tretinoin 0.025% gel in the topical treatment of acne vulgaris. J Drugs Dermatol. 2010;9(2):131–6.
PubMed
Google Scholar
NilFroushzadeh MA, Siadat AH, Baradaran EH, Moradi S. Clindamycin lotion alone versus combination lotion of clindamycin phosphate plus tretinoin versus combination lotion of clindamycin phosphate plus salicylic acid in the topical treatment of mild to moderate acne vulgaris: a randomized control trial. Indian J Dermatol Venereol Leprol. 2009;75(3):279–82.
PubMed
Article
Google Scholar
Wolf JE, Kaplan D, Kraus SJ, Loven KH, Rist T, Swinyer LJ, et al. Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindamycin: a multicenter, randomized, investigator-blinded study. J Am Acad Dermatol. 2003;49(3 Suppl):S211–7.
PubMed
Article
Google Scholar
Bhavsar B, Choksi B, Sanmukhani J, Dogra A, Haq R, Mehta S, et al. Clindamycin 1% nano-emulsion gel formulation for the treatment of acne vulgaris: results of a randomized, active controlled, multicentre, phase IV clinical trial. J Clin Diagn Res. 2014;8(8):YC05–9.
PubMed
PubMed Central
Google Scholar
Draelos ZD, Carter E, Maloney JM, Elewski B, Poulin Y, Lynde C, et al. Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris. J Am Acad Dermatol. 2007;56(3):439.e1-10.
Fleischer AB, Shalita A, Eichenfield LF, Abramovits W, Lucky A, Garrett S, et al. Dapsone gel 5% in combination with adapalene gel 0.1%, benzoyl peroxide gel 4% or moisturizer for the treatment of acne vulgaris: a 12-week, randomized, double-blind study. J Drugs Dermatol. 2010;9(1):33–40.
PubMed
Google Scholar
Langner A, Sheehan-Dare R, Layton A. A randomized, single-blind comparison of topical clindamycin + benzoyl peroxide (Duac) and erythromycin + zinc acetate (Zineryt) in the treatment of mild to moderate facial acne vulgaris. J Eur Acad Dermatol Venereol. 2007;21(3):311–9.
CAS
PubMed
Article
Google Scholar
Capitanio B, Sinagra JL, Weller RB, Brown C, Berardesca E. Randomized controlled study of a cosmetic treatment for mild acne. Clin Exp Dermatol. 2012;37(4):346–9.
CAS
PubMed
Article
Google Scholar
Lee JW, Yoo KH, Park KY, Han TY, Li K, Seo SJ, et al. Effectiveness of conventional, low-dose and intermittent oral isotretinoin in the treatment of acne: a randomized, controlled comparative study. Br J Dermatol. 2011;164(6):1369–75.
CAS
PubMed
Article
Google Scholar
Weimar VM, Puhl SC, Smith WH, tenBroeke JE. Zinc sulfate in acne vulgaris. Arch Dermatol. 1978;114(12):1776–8.
CAS
PubMed
Article
Google Scholar
Tan J, Humphrey S, Vender R, Barankin B, Gooderham M, Kerrouche N, et al. A treatment for severe nodular acne: a randomized investigator-blinded, controlled, noninferiority trial comparing fixed-dose adapalene/benzoyl peroxide plus doxycycline vs. oral isotretinoin. Br J Dermatol. 2014;171(6):1508–16.
CAS
PubMed
Article
Google Scholar
Kar BR, Tripathy S, Panda M. Comparative study of oral isotretinoin versus oral isotretinoin + 20% salicylic acid peel in the treatment of active acne. J Cutan Aesthet Surg. 2013;6(4):204–8.
PubMed
PubMed Central
Article
Google Scholar
Moore A, Ling M, Bucko A, Manna V, Rueda M-J. Efficacy and safety of subantimicrobial dose, modified-release doxycycline 40 mg versus doxycycline 100 mg versus placebo for the treatment of inflammatory lesions in moderate and severe acne: a randomized, double-blinded, controlled study. J Drugs Dermatol. 2015;14(6):581–6.
CAS
PubMed
Google Scholar
Skidmore R, Kovach R, Walker C, Thomas J, Bradshaw M, Leyden J, et al. Effects of subantimicrobial-dose doxycycline in the treatment of moderate acne. Arch Dermatol. 2003;139(4):459–64.
CAS
PubMed
Article
Google Scholar
Fowler JF. Anti-inflammatory dose doxycycline for the treatment of rosacea. Expert Rev Dermatol. 2007;2(5):523–31.
CAS
Article
Google Scholar
Leyden J, Shalita A, Hordinsky M, Swinyer L, Stanczyk FZ, Weber ME. Efficacy of a low-dose oral contraceptive containing 20 microg of ethinyl estradiol and 100 microg of levonorgestrel for the treatment of moderate acne: a randomized, placebo-controlled trial. J Am Acad Dermatol. 2002;47(3):399–409.
PubMed
Article
Google Scholar
Thiboutot D, Archer DF, Lemay A, Washenik K, Roberts J, Harrison DD. A randomized, controlled trial of a low-dose contraceptive containing 20 microg of ethinyl estradiol and 100 microg of levonorgestrel for acne treatment. Fertil Steril. 2001;76(3):461–8.
CAS
PubMed
Article
Google Scholar
Maloney JM, Dietze P, Watson D, Niknian M, Lee-Rugh S, Sampson-Landers C, et al. A randomized controlled trial of a low-dose combined oral contraceptive containing 3 mg drospirenone plus 20 microg ethinylestradiol in the treatment of acne vulgaris: lesion counts, investigator ratings and subject self-assessment. J Drugs Dermatol. 2009;8(9):837–44.
PubMed
Google Scholar
Palli MBA, Reyes-Habito CM, Lima XT, Kimball AB. A single-center, randomized double-blind, parallel-group study to examine the safety and efficacy of 3 mg drospirenone/0.02 mg ethinyl estradiol compared with placebo in the treatment of moderate truncal acne vulgaris. J Drugs Dermatol. 2013;12(6):633–7.
CAS
PubMed
Google Scholar
Shamban AT, Enokibori M, Narurkar V, Wilson D. Photopneumatic technology for the treatment of acne vulgaris. J Drugs Dermatol. 2008;7(2):139–45.
PubMed
Google Scholar
Liu L-H, Fan X, An Y-X, Zhang J, Wang C-M, Yang R-Y. Randomized trial of three phototherapy methods for the treatment of acne vulgaris in Chinese patients. Photodermatol Photoimmunol Photomed. 2014;30(5):246–53.
PubMed
Article
Google Scholar
Gold MH, Biron J. Efficacy of a novel combination of pneumatic energy and broadband light for the treatment of acne. J Drugs Dermatol. 2008;7(7):639–42.
PubMed
Google Scholar
Wanitphakdeedecha R, Tanzi EL, Alster TS. Photopneumatic therapy for the treatment of acne. J Drugs Dermatol. 2009;8(3):239–41.
PubMed
Google Scholar
Elman M, Lask G. The role of pulsed light and heat energy (LHE) in acne clearance. J Cosmet Laser Ther Off Publ Eur Soc Laser Dermatol. 2004;6(2):91–5.
Article
Google Scholar
Yeung CK, Shek SY, Bjerring P, Yu CS, Kono T, Chan HH. A comparative study of intense pulsed light alone and its combination with photodynamic therapy for the treatment of facial acne in Asian skin. Lasers Surg Med. 2007;39(1):1–6.
PubMed
Article
Google Scholar
Moftah NH, Ibrahim SM, Wahba NH. Intense pulsed light versus photodynamic therapy using liposomal methylene blue gel for the treatment of truncal acne vulgaris: a comparative randomized split body study. Arch Dermatol Res. 2016;308(4):263–8.
CAS
PubMed
Article
Google Scholar
Hong JS, Jung JY, Yoon JY, Suh DH. Acne treatment by methyl aminolevulinate photodynamic therapy with red light vs. intense pulsed light. Int J Dermatol. 2013;52(5):614–9.
CAS
PubMed
Article
Google Scholar
Oh SH, Ryu DJ, Han EC, Lee KH, Lee JH. A comparative study of topical 5-aminolevulinic acid incubation times in photodynamic therapy with intense pulsed light for the treatment of inflammatory acne. Dermatol Surg Off Publ Am Soc Dermatol Surg Al. 2009;35(12):1918–26.
CAS
Google Scholar
Taub AF. A comparison of intense pulsed light, combination radiofrequency and intense pulsed light, and blue light in photodynamic therapy for acne vulgaris. J Drugs Dermatol. 2007;6(10):1010–6.
PubMed
Google Scholar
Ma Y, Liu Y, Wang Q, Ren J, Xiang L. Prospective study of topical 5-aminolevulinic acid photodynamic therapy for the treatment of severe adolescent acne in Chinese patients. J Dermatol. 2015;42(5):504–7.
CAS
PubMed
Article
Google Scholar
Mei X, Shi W, Piao Y. Effectiveness of photodynamic therapy with topical 5-aminolevulinic acid and intense pulsed light in Chinese acne vulgaris patients. Photodermatol Photoimmunol Photomed. 2013;29(2):90–6.
CAS
PubMed
Article
Google Scholar
Paithankar DY, Sakamoto FH, Farinelli WA, Kositratna G, Blomgren RD, Meyer TJ, et al. Acne treatment based on selective photothermolysis of sebaceous follicles with topically delivered light-absorbing gold microparticles. J Invest Dermatol. 2015;135(7):1727–34.
CAS
PubMed
PubMed Central
Article
Google Scholar
Haedersdal M, Togsverd-Bo K, Wiegell SR, Wulf HC. Long-pulsed dye laser versus long-pulsed dye laser-assisted photodynamic therapy for acne vulgaris: a randomized controlled trial. J Am Acad Dermatol. 2008;58(3):387–94.
PubMed
Article
Google Scholar
Alexiades-Armenakas M. Long-pulsed dye laser-mediated photodynamic therapy combined with topical therapy for mild to severe comedonal, inflammatory, or cystic acne. J Drugs Dermatol. 2006;5(1):45–55.
PubMed
Google Scholar
Gold MH, Sensing W, Biron JA. Clinical efficacy of home-use blue-light therapy for mild-to moderate acne. J Cosmet Laser Ther Off Publ Eur Soc Laser Dermatol. 2011;13(6):308–14.
Article
Google Scholar
Handler MZ, Bloom BS, Goldberg DJ. Energy-based devices in treatment of acne vulgaris. Dermatol Surg Off Publ Am Soc Dermatol Surg Al. 2016;42(5):573–85.
CAS
Google Scholar
Na JI, Suh DH. Red light phototherapy alone is effective for acne vulgaris: randomized, single-blinded clinical trial. Dermatol Surg Off Publ Am Soc Dermatol Surg Al. 2007;33(10):1228–33 (discussion 1233).
CAS
Google Scholar
Aziz-Jalali MH, Tabaie SM, Djavid GE. Comparison of red and infrared low-level laser therapy in the treatment of acne vulgaris. Indian J Dermatol. 2012;57(2):128–30.
PubMed
PubMed Central
Article
Google Scholar
de Arruda LHF, Kodani V, Bastos Filho A, Mazzaro CB. A prospective, randomized, open and comparative study to evaluate the safety and efficacy of blue light treatment versus a topical benzoyl peroxide 5% formulation in patients with acne grade II and III. An Bras Dermatol. 2009;84(5):463–8.
PubMed
Article
Google Scholar
Pollock B, Turner D, Stringer MR, Bojar RA, Goulden V, Stables GI, et al. Topical aminolaevulinic acid-photodynamic therapy for the treatment of acne vulgaris: a study of clinical efficacy and mechanism of action. Br J Dermatol. 2004;151(3):616–22.
CAS
PubMed
Article
Google Scholar
Taub AF. Photodynamic therapy for the treatment of acne: a pilot study. J Drugs Dermatol. 2004;3(6 Suppl):S10–4.
PubMed
Google Scholar
Akaraphanth R, Kanjanawanitchkul W, Gritiyarangsan P. Efficacy of ALA-PDT vs blue light in the treatment of acne. Photodermatol Photoimmunol Photomed. 2007;23(5):186–90.
CAS
PubMed
Article
Google Scholar
Bissonnette R, Maari C, Nigen S, Provost N, Bolduc C. Photodynamic therapy with methylaminolevulinate 80 mg/g without occlusion improves acne vulgaris. J Drugs Dermatol. 2010;9(11):1347–52.
PubMed
Google Scholar
Wiegell SR, Wulf HC. Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid versus methyl aminolevulinate. J Am Acad Dermatol. 2006;54(4):647–51.
PubMed
Article
Google Scholar
Wiegell SR, Wulf HC. Photodynamic therapy of acne vulgaris using methyl aminolaevulinate: a blinded, randomized, controlled trial. Br J Dermatol. 2006;154(5):969–76.
CAS
PubMed
Article
Google Scholar
Papageorgiou P, Katsambas A, Chu A. Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris. Br J Dermatol. 2000;142(5):973–8.
CAS
PubMed
Article
Google Scholar
Lee SY, You CE, Park MY. Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV. Lasers Surg Med. 2007;39(2):180–8.
PubMed
Article
Google Scholar
Kwon HH, Lee JB, Yoon JY, Park SY, Ryu HH, Park BM, et al. The clinical and histological effect of home-use, combination blue-red LED phototherapy for mild-to-moderate acne vulgaris in Korean patients: a double-blind, randomized controlled trial. Br J Dermatol. 2013;168(5):1088–94.
CAS
PubMed
Article
Google Scholar
Ilknur T, Demirtaşoğlu M, Biçak MU, Ozkan S. Glycolic acid peels versus amino fruit acid peels for acne. J Cosmet Laser Ther Off Publ Eur Soc Laser Dermatol. 2010;12(5):242–5.
Article
Google Scholar
Levesque A, Hamzavi I, Seite S, Rougier A, Bissonnette R. Randomized trial comparing a chemical peel containing a lipophilic hydroxy acid derivative of salicylic acid with a salicylic acid peel in subjects with comedonal acne. J Cosmet Dermatol. 2011;10(3):174–8.
PubMed
Article
Google Scholar
Leyden JJ. New understandings of the pathogenesis of acne. J Am Acad Dermatol. 1995;32(5, Part 3):S15–25.
CAS
PubMed
Article
Google Scholar
Lavker RM, Leyden JJ, McGinley KJ. The relationship between bacteria and the abnormal follicular keratinization in acne vulgaris. J Invest Dermatol. 1981;77(3):325–30.
CAS
PubMed
Article
Google Scholar
Thiboutot D, Gollnick H, Bettoli V, Dréno B, Kang S, Leyden JJ, et al. New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group. J Am Acad Dermatol. 2009;60(5 Suppl):S1–50.
PubMed
Article
Google Scholar
Ioannides D, Rigopoulos D, Katsambas A. Topical adapalene gel 0.1% vs. isotretinoin gel 0.05% in the treatment of acne vulgaris: a randomized open-label clinical trial. Br J Dermatol. 2002;147(3):523–7.
CAS
PubMed
Article
Google Scholar
Leyden JJ, Tanghetti EA, Miller B, Ung M, Berson D, Lee J. Once-daily tazarotene 0.1% gel versus once-daily tretinoin 0.1% microsponge gel for the treatment of facial acne vulgaris: a double-blind randomized trial. Cutis. 2002;69(2 Suppl):12–9.
PubMed
Google Scholar
Kircik LH. Microsphere technology: hype or help? J Clin Aesthet Dermatol. 2011;4(5):27–31.
PubMed
PubMed Central
Google Scholar
Poulin Y, Sanchez NP, Bucko A, Fowler J, Jarratt M, Kempers S, et al. A 6-month maintenance therapy with adapalene-benzoyl peroxide gel prevents relapse and continuously improves efficacy among patients with severe acne vulgaris: results of a randomized controlled trial. Br J Dermatol. 2011;164(6):1376–82.
CAS
PubMed
Article
Google Scholar
Seidler EM, Kimball AB. Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne. J Am Acad Dermatol. 2010;63(1):52–62.
CAS
PubMed
Article
Google Scholar
Ozolins M, Eady EA, Avery AJ, Cunliffe WJ, Po ALW, O’Neill C, et al. Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial. Lancet Lond Engl. 2004;364(9452):2188–95.
CAS
Article
Google Scholar
Del Rosso JQ, Kircik L, Gallagher CJ. Comparative efficacy and tolerability of dapsone 5% gel in adult versus adolescent females with acne vulgaris. J Clin Aesthet Dermatol. 2015;8(1):31–7.
PubMed
PubMed Central
Google Scholar
Lucky AW, Maloney JM, Roberts J, Taylor S, Jones T, Ling M, et al. Dapsone gel 5% for the treatment of acne vulgaris: safety and efficacy of long-term (1 year) treatment. J Drugs Dermatol. 2007;6(10):981–7.
PubMed
Google Scholar
Skinoren Cream—Summary of Product Characteristics (SPC)-(eMC) [Internet]. (cited 2016 Jun 11). Available from: https://www.medicines.org.uk/emc/medicine/19239/SPC/Skinoren+Cream/.
Sieber MA, Hegel JKE. Azelaic acid: properties and mode of action. Skin Pharmacol Physiol. 2014;27(Suppl 1):9–17.
CAS
PubMed
Article
Google Scholar
Mastrofrancesco A, Ottaviani M, Aspite N, Cardinali G, Izzo E, Graupe K, et al. Azelaic acid modulates the inflammatory response in normal human keratinocytes through PPARgamma activation. Exp Dermatol. 2010;19(9):813–20.
CAS
PubMed
Article
Google Scholar
Briganti S, Flori E, Mastrofrancesco A, Kovacs D, Camera E, Ludovici M, et al. Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts: possible implication of PPARγ. Exp Dermatol. 2013;22(1):41–7.
CAS
PubMed
Article
Google Scholar
Akamatsu H, Komura J, Asada Y, Miyachi Y, Niwa Y. Inhibitory effect of azelaic acid on neutrophil functions: a possible cause for its efficacy in treating pathogenetically unrelated diseases. Arch Dermatol Res. 1991;283(3):162–6.
CAS
PubMed
Article
Google Scholar
Passi S, Picardo M, De Luca C, Breathnach AS, Nazzaro-Porro M. Scavenging activity of azelaic acid on hydroxyl radicals “in vitro”. Free Radic Res Commun. 1991;11(6):329–38.
CAS
PubMed
Article
Google Scholar
Draelos ZD. The rationale for advancing the formulation of azelaic acid vehicles. Cutis. 2006;77(2 Suppl):7–11.
PubMed
Google Scholar
Draelos ZD, Elewski BE, Harper JC, Sand M, Staedtler G, Nkulikiyinka R, et al. A phase 3 randomized, double-blind, vehicle-controlled trial of azelaic acid foam 15% in the treatment of papulopustular rosacea. Cutis. 2015;96(1):54–61.
PubMed
Google Scholar
Finacea (azelaic acid) Foam [Internet]. (cited 2016 Jun 29). Available from: http://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/207071Orig1s000TOC.cfm.
Gollnick HPM, Graupe K, Zaumseil R-P. Azelaic acid 15% gel in the treatment of acne vulgaris. Combined results of two double-blind clinical comparative studies. J Dtsch Dermatol Ges J Ger Soc Dermatol. 2004;2(10):841–7.
Article
Google Scholar
Novan Therapeutics:: Novan’s Phase 2b Results to be Presented at AAD [Internet]. (cited 2016 Jun 12). Available from: http://www.novantherapeutics.com/investors-media/press-releases/novans-phase-2b-results-be-presented-aad/.
PowerPoint Presentation - Novan_Phase_2b_AAD_2016.pdf [Internet]. (cited 2016 Jun 12). Available from: http://www.novantherapeutics.com/files/1114/6040/2416/Novan_Phase_2b_AAD_2016.pdf.
DRM01: Dermira [Internet]. (cited 2016 Jun 12). Available from: http://dermira.com/pipeline/drm01/.
Walsh TR, Efthimiou J, Dréno B. Systematic review of antibiotic resistance in acne: an increasing topical and oral threat. Lancet Infect Dis. 2016;16(3):e23–33.
CAS
PubMed
Article
Google Scholar
Elewski BE, Lamb BA, Sams WM, Gammon WR. In vivo suppression of neutrophil chemotaxis by systemically and topically administered tetracycline. J Am Acad Dermatol. 1983;8(6):807–12.
CAS
PubMed
Article
Google Scholar
Van Boeckel TP, Gandra S, Ashok A, Caudron Q, Grenfell BT, Levin SA, et al. Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data. Lancet Infect Dis. 2014;14(8):742–50.
PubMed
Article
Google Scholar
McCaig LF, Hughes JM. Trends in antimicrobial drug prescribing among office-based physicians in the United States. JAMA. 1995;273(3):214–9.
CAS
PubMed
Article
Google Scholar
Watson RL, Dowell SF, Jayaraman M, Keyserling H, Kolczak M, Schwartz B. Antimicrobial use for pediatric upper respiratory infections: reported practice, actual practice, and parent beliefs. Pediatrics. 1999;104(6):1251–7.
CAS
PubMed
Article
Google Scholar
Meeker D, Linder JA, Fox CR, et al. Effect of behavioral interventions on inappropriate antibiotic prescribing among primary care practices: a randomized clinical trial. JAMA. 2016;315(6):562–70.
CAS
PubMed
Article
Google Scholar
Gollnick H, Cunliffe W, Berson D, Dreno B, Finlay A, Leyden JJ, et al. Management of acne: a report from a global alliance to improve outcomes in acne. J Am Acad Dermatol. 2003;49(1 Suppl):S1–37.
PubMed
Article
Google Scholar
Dréno B. Bacteriological resistance in acne: A call to action. Eur J Dermatol EJD. 2015.
Dréno B, Bettoli V, Ochsendorf F, Layton A, Mobacken H, Degreef H, et al. European recommendations on the use of oral antibiotics for acne. Eur J Dermatol. 2004;14(6):391–9.
PubMed
Google Scholar
Nast A, Dréno B, Bettoli V, Degitz K, Erdmann R, Finlay AY, et al. European evidence-based (S3) guidelines for the treatment of acne. J Eur Acad Dermatol Venereol. 2012;26(Suppl 1):1–29.
PubMed
Article
Google Scholar
Thiboutot D. Rethinking treatment of acne in the severe patient. J Drugs Dermatol. 2011;10(6):s8–12.
PubMed
Google Scholar
Nagler AR, Milam EC, Orlow SJ. The use of oral antibiotics before isotretinoin therapy in patients with acne. J Am Acad Dermatol. 2016;74(2):273–9.
CAS
PubMed
Article
Google Scholar
Peck GL, Olsen TG, Butkus D, Pandya M, Arnaud-Battandier J, Gross EG, et al. Isotretinoin versus placebo in the treatment of cystic acne. A randomized double-blind study. J Am Acad Dermatol. 1982;6(4 Pt 2 Suppl):735–45.
CAS
PubMed
Article
Google Scholar
Goldsmith LA, Bolognia JL, Callen JP, Chen SC, Feldman SR, Lim HW, et al. American Academy of Dermatology Consensus Conference on the safe and optimal use of isotretinoin: summary and recommendations. J Am Acad Dermatol. 2004;50(6):900–6.
PubMed
Article
Google Scholar
Lehucher-Ceyrac D, de La Salmonière P, Chastang C, Morel P. Predictive factors for failure of isotretinoin treatment in acne patients: results from a cohort of 237 patients. Dermatol Basel Switz. 1999;198(3):278–83.
CAS
Article
Google Scholar
Blasiak RC, Stamey CR, Burkhart CN, Lugo-Somolinos A, Morrell DS. High-dose isotretinoin treatment and the rate of retrial, relapse, and adverse effects in patients with acne vulgaris. JAMA Dermatol. 2013;149(12):1392–8.
CAS
PubMed
Article
Google Scholar
Rubinow DR, Peck GL, Squillace KM, Gantt GG. Reduced anxiety and depression in cystic acne patients after successful treatment with oral isotretinoin. J Am Acad Dermatol. 1987;17(1):25–32.
CAS
PubMed
Article
Google Scholar
Etminan M, Bird ST, Delaney JA, Bressler B, Brophy JM. Isotretinoin and risk for inflammatory bowel disease: a nested case-control study and meta-analysis of published and unpublished data. JAMA Dermatol. 2013;149(2):216–20.
PubMed
Article
Google Scholar
Chia CY, Lane W, Chibnall J, Allen A, Siegfried E. Isotretinoin therapy and mood changes in adolescents with moderate to severe acne: a cohort study. Arch Dermatol. 2005;141(5):557–60.
CAS
PubMed
Article
Google Scholar
Cohen J, Adams S, Patten S. No association found between patients receiving isotretinoin for acne and the development of depression in a Canadian prospective cohort. Can J Clin Pharmacol. 2007;14(2):e227–33.
PubMed
Google Scholar
Yentzer BA, Hick J, Reese EL, Uhas A, Feldman SR, Balkrishnan R. Acne vulgaris in the United States: a descriptive epidemiology. Cutis. 2010;86(2):94–9.
PubMed
Google Scholar
Goulden V, Clark SM, Cunliffe WJ. Post-adolescent acne: a review of clinical features. Br J Dermatol. 1997;136(1):66–70.
CAS
PubMed
Article
Google Scholar
Till AE, Goulden V, Cunliffe WJ, Holland KT. The cutaneous microflora of adolescent, persistent and late-onset acne patients does not differ. Br J Dermatol. 2000;142(5):885–92.
CAS
PubMed
Article
Google Scholar
Imperato-McGinley J, Gautier T, Cai LQ, Yee B, Epstein J, Pochi P. The androgen control of sebum production. Studies of subjects with dihydrotestosterone deficiency and complete androgen insensitivity. J Clin Endocrinol Metab. 1993;76(2):524–8.
CAS
PubMed
Google Scholar
Lolis MS, Bowe WP, Shalita AR. Acne and systemic disease. Med Clin North Am. 2009;93(6):1161–81.
CAS
PubMed
Article
Google Scholar
Thiboutot D, Chen W. Update and future of hormonal therapy in acne. Dermatol Basel Switz. 2003;206(1):57–67.
Article
Google Scholar
Lucky AW, Koltun W, Thiboutot D, Niknian M, Sampson-Landers C, Korner P, et al. A combined oral contraceptive containing 3-mg drospirenone/20-microg ethinyl estradiol in the treatment of acne vulgaris: a randomized, double-blind, placebo-controlled study evaluating lesion counts and participant self-assessment. Cutis. 2008;82(2):143–50.
PubMed
Google Scholar
Muhlemann MF, Carter GD, Cream JJ, Wise P. Oral spironolactone: an effective treatment for acne vulgaris in women. Br J Dermatol. 1986;115(2):227–32.
CAS
PubMed
Article
Google Scholar
Kim GK, Del Rosso JQ. Oral spironolactone in post-teenage female patients with acne vulgaris: practical considerations for the clinician based on current data and clinical experience. J Clin Aesthet Dermatol. 2012;5(3):37–50.
CAS
PubMed
PubMed Central
Google Scholar
Plovanich M, Weng QY, Mostaghimi A. Low usefulness of potassium monitoring among healthy young women taking spironolactone for acne. JAMA Dermatol. 2015;151(9):941–4.
PubMed
Article
Google Scholar
Trifu V, Tiplica G-S, Naumescu E, Zalupca L, Moro L, Celasco G. Cortexolone 17α-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 0.05% cream. Br J Dermatol. 2011;165(1):177–83.
CAS
PubMed
Article
Google Scholar
Afzali BM, Yaghoobi E, Yaghoobi R, Bagherani N, Dabbagh MA. Comparison of the efficacy of 5% topical spironolactone gel and placebo in the treatment of mild and moderate acne vulgaris: a randomized controlled trial. J Dermatol Treat. 2012;23(1):21–5.
CAS
Article
Google Scholar
Dréno B, Fischer TC, Perosino E, Poli F, Viera MS, Rendon MI, et al. Expert opinion: efficacy of superficial chemical peels in active acne management—what can we learn from the literature today? Evidence-based recommendations. J Eur Acad Dermatol Venereol. 2011;25(6):695–704.
PubMed
Article
Google Scholar
Lee H-S, Kim I-H. Salicylic acid peels for the treatment of acne vulgaris in Asian patients. Dermatol Surg Off Publ Am Soc Dermatol Surg Al. 2003;29(12):1196–9 (discussion 1199).
Google Scholar
Pariser DM, Eichenfield LF, Bukhalo M, Waterman G, Jarratt M. PDT Study Group. Photodynamic therapy with methyl aminolaevulinate 80 mg g(−1) for severe facial acne vulgaris: a randomized vehicle-controlled study. Br J Dermatol. 2016;174(4):770–7.
CAS
PubMed
Article
Google Scholar
Potter RA. Intralesional triamcinolone and adrenal suppression in acne vulgaris. J Invest Dermatol. 1971;57(6):364–70.
CAS
PubMed
Article
Google Scholar
Karimipour DJ, Karimipour G, Orringer JS. Microdermabrasion: an evidence-based review. Plast Reconstr Surg. 2010;125(1):372–7.
CAS
PubMed
Article
Google Scholar