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Syndromes carentiels sévères

Severe vitamin deficiencies

  • Enseignement Supérieur en Réanimation
  • Published:
Réanimation

Résumé

La prévalence des carences vitaminiques est probablement sous-estimée. Le rôle du réanimateur est donc de les reconnaître au cours des situations à risque. Cela est d’autant plus important que certaines carences peuvent être mortelles, comme le syndrome de Gayet-Wernicke (SGW), le shoshin béribéri et le scorbut, alors que leur évolution peut être rapidement favorable grâce à une supplémentation adaptée.

Abstract

The prevalence of vitamin deficiencies is underestimated. Risk factors for these deficiencies should be recognized in the intensive care unit. Some among these deficiencies can be fatal including Wernicke encephalopathy, shoshin beriberi, and scurvy; however they may recover dramatically with appropriate supplementation.

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Références

  1. Cook CC, Hallwood PM, Thomson AD (1998) B Vitamin deficiency and neuropsychiatric syndromes in alcohol misuse. Alcohol Alcohol 33:317–336

    Article  PubMed  CAS  Google Scholar 

  2. Thomson AD, Marshall EJ (2006) The natural history and pathophysiology of Wernicke’s encephalopathy and Korsakoff’s psychosis. Alcohol Alcohol 41:151–158

    Article  PubMed  CAS  Google Scholar 

  3. Folope V, Coeffier M, Dechelotte P (2007) Nutritional deficiencies associated with bariatric surgery. Gastroenterol Clin Biol 31:369–377

    Article  PubMed  Google Scholar 

  4. Singh S, Kumar A (2007) Wernicke encephalopathy after obesity surgery: a systematic review. Neurology 68:807–811

    Article  PubMed  Google Scholar 

  5. Morel L, Fontana E, Michel JM, et al (2008) A new treatment: bariatric surgery; a new complication: Wernicke-Korsakoff encephalopathy. Presse Med 37:49–53

    Article  PubMed  Google Scholar 

  6. Merola JF, Ghoroghchian PP, Samuels MA, et al (2012) Clinical problem-solving. At a loss. N Engl J Med 367:67–72

    Article  CAS  Google Scholar 

  7. Ashourian N, Mousdicas N (2006) Images in clinical medicine. Pellagra-like dermatitis. N Engl J Med 354:1614

    Article  PubMed  CAS  Google Scholar 

  8. Thomson AD, Cook CC, Guerrini I, et al (2008) Wernicke’s encephalopathy revisited. Translation of the case history section of the original manuscript by Carl Wernicke “Lehrbuch der Gehirnkrankheiten fur Aerzte and Studirende” (1881) with a commentary. Alcohol Alcohol 43:174–179

    Article  PubMed  Google Scholar 

  9. Blass JP, Gibson GE (1977) Abnormality of a thiamine-requiring enzyme in patients with Wernicke-Korsakoff syndrome. N Engl J Med 297:1367–1370

    Article  PubMed  CAS  Google Scholar 

  10. Donnino MW, Vega J, Miller J, Walsh M (2007) Myths and misconceptions of Wernicke’s encephalopathy: what every emergency physician should know. Ann Emerg Med 50:715–721

    Article  PubMed  Google Scholar 

  11. Cognat E HE, Mesnage V, Levy R (2011) Severe dysautonomia revealing Wernicke’s encephalopathy. Rev Neurol 167:250–253

    Article  PubMed  CAS  Google Scholar 

  12. Mancinelli RCM, Guiducci MS, Sasso GF, et al (2003) Simultaneous liquid chromatographic assessment of thiamine, thiamine monophosphate and thiamine diphosphate in human erythrocytes: a study on alcoholics. J Chromatogr B Analyt Technol Biomed Life Sci 789:355–363

    Article  PubMed  CAS  Google Scholar 

  13. Zuccoli G, Pipitone N (2009) Neuroimaging findings in acute Wernicke’s encephalopathy: review of the literature. AJR Am J Roentgenol 192:501–508

    Article  PubMed  Google Scholar 

  14. Sechi G, Serra A (2007) Wernicke’s encephalopathy: new clinical settings and recent advances in diagnosis and management. Lancet Neurol 6:442–455

    Article  PubMed  CAS  Google Scholar 

  15. Restier J, de Carsalade GY, Ahmed Abdou M, et al (2012) Shoshin beriberi: new emergence of an old pathology? About with 11 cases on island Mayotte. Bull Soc Pathol Exot 105:49–57

    Article  PubMed  CAS  Google Scholar 

  16. Watson JT, El Bushra H, Lebo EJ, et al (2011) Outbreak of beriberi among African Union troops in Mogadishu, Somalia. PLoS One 6:e28345

    Article  PubMed  CAS  Google Scholar 

  17. Faigle R MM, Levy M (2012) Dry beriberi mimicking Guillain-Barre syndrome as the first presenting sign of thiamine deficiency. Eur J Neurol 19:e14–e15

    Article  PubMed  CAS  Google Scholar 

  18. Koike H IM, Sugiura M, Mori K, et al (2003) Alcoholic neuropathy is clinicopathologically distinct fromthiamine-deficiency neuropathy. Ann Neurol 54:19–29

    Article  PubMed  Google Scholar 

  19. Koike HMK, Misu K, Hattori N, et al (2001) Painful alcoholic polyneuropathy with predominant small-fiber loss and normal thiamine status. Neurology 56:1727–1732

    Article  PubMed  CAS  Google Scholar 

  20. Blankerhorn MAVC (1946) Occidental beriberi heart disease. JAMA 131:717–726

    Article  Google Scholar 

  21. McIntyre N, Stanley NN (1971) Cardiac beriberi: two modes of presentation. Br Med J 3:567–569

    Article  PubMed  CAS  Google Scholar 

  22. Wolf PL LM (1960) Shoshin beriberi. N Engl J Med 262:1302–1306

    Article  Google Scholar 

  23. Daly MJ, Dixon LJ (2009) A case of ST-elevation and nystagmus — when coronary thrombosis is not to blame. QJM 102:737–739

    Article  PubMed  CAS  Google Scholar 

  24. Kountchev J, Bijuklic K, Bellmann R, Joannidis M (2005) A patient with severe lactic acidosis and rapidly evolving multiple organ failure: a case of shoshin beriberi. Intensive Care Med 31:1004

    Article  PubMed  CAS  Google Scholar 

  25. Richard C, Fond B, Auzepy P (1982) Shoshin beriberi. Lancet 2:215

    Article  PubMed  CAS  Google Scholar 

  26. Yamasaki H, Tada H, Kawano S, Aonuma K (2010) Reversible pulmonary hypertension, lactic acidosis, and rapidly evolving multiple organ failure as manifestations of shoshin beriberi. Circ J 74:1983–1985

    Article  PubMed  Google Scholar 

  27. Wan P, Moat S, Anstey A (2011) Pellagra: a review with emphasis on photosensitivity. Br J Dermatol 164:1188–1200

    Article  PubMed  CAS  Google Scholar 

  28. Semba RD (2000) Theophile Roussel and the elimination of pellagra from 19th century France. Nutrition 16:231–233

    Article  PubMed  CAS  Google Scholar 

  29. Mercieri M, Mercieri A (2011) Images in clinical medicine: a photosensitive dermatitis in the intensive care unit. N Engl J Med 364:361

    Article  PubMed  CAS  Google Scholar 

  30. Zaki I, Millard L (1995) Pellagra complicating Crohn’s disease. Postgrad Med J 71:496–497

    Article  PubMed  CAS  Google Scholar 

  31. Ishii N, Nishihara Y (1985) Pellagra encephalopathy among tuberculous patients: its relation to isoniazid therapy. J Neurol Neurosurg Psychiatry 48:628–634

    Article  PubMed  CAS  Google Scholar 

  32. Latham (1997) Pellagra. In: Human Nutrition in the Developing World. Food Nutr 29:17

    Google Scholar 

  33. Beretich GR Jr (2005) Do high leucine /low tryptophan dieting foods (yogurt, gelatin) with niacin supplementation cause neuropsychiatric symptoms (depression) but not dermatological symptoms of pellagra? Med Hypotheses 65:628–629

    Article  PubMed  CAS  Google Scholar 

  34. Spector JM (2005) “Sour skin” in Darfur, Sudan. Arch Dis Child 90:783

    Article  PubMed  CAS  Google Scholar 

  35. Serdaru MHHC, Laplane D, Buge A, et al (1988) The clinical spectrum of alcoholic pellagra encephalopathy. Brain 111: 829–842

    Article  PubMed  Google Scholar 

  36. Alvarez FG, Guntupalli KK (1995) Isoniazid overdose: four case reports and review of the literature. Intensive Care Med 21(8):641–644

    Article  PubMed  CAS  Google Scholar 

  37. Walker SPWP, Ihle BU (1997) Severe folate deficiency masquerading as the syndrome of hemolysis, elevated liver enzymes, and low platelets. Obstet Gynecol 90:655–657

    Article  PubMed  CAS  Google Scholar 

  38. Lever EG, Elwes RD, Williams A, Reynolds EH (1986) Subacute combined degeneration of the cord due to folate deficiency: response to methyl folate treatment. J Neurol Neurosurg Psychiatry 49:1203–1207

    Article  PubMed  CAS  Google Scholar 

  39. Ramaekers VT, Rothenberg SP, Sequeira JM, et al (2005) Autoantibodies to folate receptors in the cerebral folate deficiency syndrome. N Engl J Med 352:1985–1991

    Article  PubMed  CAS  Google Scholar 

  40. Sadighi Z, Butler IJ, Koenig MK (2012) Adult-onset cerebral folate deficiency. Arch Neurol 69:778–779

    PubMed  Google Scholar 

  41. Koenig MK, Perez M, Rothenberg S, Butler IJ (2008) Juvenile onset central nervous system folate deficiency and rheumatoid arthritis. J Child Neurol 23:106–107

    Article  PubMed  Google Scholar 

  42. Dali-Youcef N, Andres E (2009) An update on cobalamin deficiency in adults. QJM 102:17–28

    Article  PubMed  CAS  Google Scholar 

  43. Rabhi S, Maaroufi M, Khibri H, et al (2011) Magnetic resonance imaging findings within the posterior and lateral columns of the spinal cord extended from the medulla oblongata to the thoracic spine in a woman with subacute combined degeneration without hematologic disorders: a case report and review of the literature. J Med Case Rep 5:166

    Article  PubMed  Google Scholar 

  44. Garderet L, Maury E, Lagrange M, et al (2003) Schizocytosis in pernicious anemia mimicking thrombotic thrombocytopenic purpura. Am J Med 114:423–425

    Article  PubMed  Google Scholar 

  45. Carmel R, Melnyk S, James SJ (2003) Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism. Blood 101:3302–3308

    Article  PubMed  CAS  Google Scholar 

  46. Dhar M, Bellevue R, Carmel R (2003) Pernicious anemia with neuropsychiatric dysfunction in a patient with sickle cell anemia treated with folate supplementation. N Engl J Med 348:2204–2207

    Article  PubMed  Google Scholar 

  47. Marks PW, Zukerberg LR (2004) A 37-year-old woman with paresthesias of the arms and legs. N Engl J Med 351:1333–1341

    Article  PubMed  CAS  Google Scholar 

  48. Chauvet E, Youssef M, Boukhari R, et al (2009) Symptoms of HELLP syndrome due to vitamin B12 deficiency: report of seven cases. J Gynecol Obstet Biol Reprod (Paris) 38:226–230

    Article  CAS  Google Scholar 

  49. Beringer TR, Patterson VH (1984) Lhermitte’s sign as the presenting symptom of vitamin B12 deficiency. Ulster Med J 53:162–163

    PubMed  CAS  Google Scholar 

  50. Yang DT, Cook RJ (2012) Spurious elevations of vitamin B12 with pernicious anemia. N Engl J Med 366:1742–1743

    Article  PubMed  CAS  Google Scholar 

  51. Nexo E, Hoffmann-Lucke E (2011) Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utility. Am J Clin Nutr 94:359S–365S

    Article  PubMed  CAS  Google Scholar 

  52. Pimentel L (2003) Scurvy: historical review and current diagnostic approach. Am J Emerg Med 21:328–332

    Article  PubMed  Google Scholar 

  53. Manchester KL (1998) An orange a day keeps the scurvy away. Trends Pharmacol Sci 19:167–170

    Article  PubMed  CAS  Google Scholar 

  54. Hirschmann JV, Raugi GJ (1999) Adult scurvy. J Am Acad Dermatol 41:895–906; quiz 7–10

    Article  PubMed  CAS  Google Scholar 

  55. Mertens MT, Gertner E (2011) Rheumatic manifestations of scurvy: a report of three recent cases in a major urban center and a review. Semin Arthritis Rheum 41:286–290

    Article  PubMed  Google Scholar 

  56. Kupari M, Rapola J (2012) Reversible pulmonary hypertension associated with vitamin C deficiency. Chest 142:225–227

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Service de réanimation médicale, hôpital Saint-Antoine, Assistance publique-Hôpitaux de Paris, F-75012, Paris, France

    E. Maury, N. Bigé, M. Alves, A. Galbois, H. Ait-Oufella, J. -L. Baudel, G. Offenstadt & B. Guidet

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  1. E. Maury
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  2. N. Bigé
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  3. M. Alves
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  4. A. Galbois
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  5. H. Ait-Oufella
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  6. J. -L. Baudel
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  7. G. Offenstadt
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  8. B. Guidet
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Correspondence to E. Maury.

Additional information

Cet article correspond à la conférence faite par l’auteur au congrès de la SRLF 2013 dans la session: Des maladies qu’il faut connaître.

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Maury, E., Bigé, N., Alves, M. et al. Syndromes carentiels sévères. Réanimation 22 (Suppl 2), 417–427 (2013). https://doi.org/10.1007/s13546-012-0627-x

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  • DOI: https://doi.org/10.1007/s13546-012-0627-x

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