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Ethylene glycol induced renal toxicity in female Wistar rats

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Abstract

The calcium oxalate nephrolithiasis due to ethylene glycol treatment has long been observed in male species but the prevalence of calcium oxalate nephrolithiasis in female species due to ethylene glycol has been still a subject of controversy. Ethylene glycol was administered in drinking water at three different doses (0.4%, 0.75% and 1.0%, v/v) for 28 days in female Wistar rats. Ethylene glycol treatment caused significant decrease in body weight and corresponding increase in relative organ weight with significant hypercalciuria, hyperoxaluria and proteinuria as well as increased retention of calcium, oxalate, phosphate and total protein in kidney in a dose — and time — dependent manner. However, calcium level was significantly reduced in the serum while an increase in total protein and phosphate level in serum was observed. Furthermore, there was a significant reduction in magnesium level in urine, serum and kidney due to ethylene glycol. The effects were also confirmed in histopathological studies.

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  1. Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad, 380009, India

    Sarmistha Saha & Ramtej J. Verma

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  1. Sarmistha Saha
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  2. Ramtej J. Verma
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Correspondence to Sarmistha Saha.

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Saha, S., Verma, R.J. Ethylene glycol induced renal toxicity in female Wistar rats. Toxicol. Environ. Health Sci. 5, 207–214 (2013). https://doi.org/10.1007/s13530-013-0180-7

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  • DOI: https://doi.org/10.1007/s13530-013-0180-7

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