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Impaired central sensitivity to triiodothyronine is associated with gestational diabetes mellitus

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Background

Thyroid hormones play an important role in the regulation of glucose metabolism. Recently, some studies determined the relationship between diabetes and abnormality of indices of thyroid hormone sensitivity. Thyroid dysfunction may play a role in the etiology of gestational diabetes mellitus (GDM).

Objective

In the present study, we aim to determine central and peripheral thyroid hormone resistance by evaluating indices of thyroid hormone sensitivity and thyroid function tests and to investigate its effect on the etiology of GDM.

Methods

A total of 1416 euthyroid pregnant women were included in this study. Of these, 241 (17%) had GDM and 1175 (83%) did not have GDM. We evaluated the association of indices of sensitivity to thyroid hormones including TFQIFT4, TFQIFT3, TSHI, TT4RI, and FT3/FT4, with GDM in pregnant euthyroid women.

Results

We found higher FT3, TFQIFT3, and FT3/FT4 ratio in the GDM group. The present study also showed that significantly increased FT3 and TFQIFT3 levels were associated with a higher risk of GDM after adjustment for potential confounding factors such as age and body mass index (BMI).

Conclusions

FT3 and TFQIFT3 were independently associated with the risk of GDM. The results of the present study may shed light on future studies by providing new information on the association of FT3 at the first antenatal visit with GDM.

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Gülhane Faculty of Medicine, University of Health Sciences, Ankara, Turkey

    Safak Akin & Nese Ersoz Gulcelik

  2. Department of Molecular Endocrinology, Gülhane Institute of Health Sciences, University of Health Sciences, Ankara, Turkey

    Safak Akin & Nese Ersoz Gulcelik

  3. Department of Obstetrics and Gynecology, Gülhane Faculty of Medicine, University of Health Sciences, Ankara, Turkey

    Pinar Ulgen, Busra Sen Yildirim & Ozhan Ozdemir

  4. Department of Medical Informatics, Gülhane Faculty of Medicine, University of Health Sciences, Ankara, Turkey

    Eda Karaismailoglu

Authors
  1. Safak Akin
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  2. Pinar Ulgen
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  3. Busra Sen Yildirim
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  4. Eda Karaismailoglu
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  5. Ozhan Ozdemir
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  6. Nese Ersoz Gulcelik
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Contributions

Nese Ersoz Gulcelik and Safak Akin designed the study. Safak Akin, Pinar Ulgen, Busra Sen Yildirim, and Ozhan Ozdemir contributed to data collection. Safak Akin and Eda Karaismailoglu performed statistical analysis. Safak Akin contributed to data analysis and writing the paper. Nese Ersoz Gulcelik provided lots of useful comments in this work. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Safak Akin.

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Ethics approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Gülhane Training and Research Hospital (Date 06.04.2022/No 2022/35).

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Written informed consent was obtained from each participant before the measurement.

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The authors declare no competing interests.

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Akin, S., Ulgen, P., Yildirim, B.S. et al. Impaired central sensitivity to triiodothyronine is associated with gestational diabetes mellitus. Int J Diabetes Dev Ctries (2024). https://doi.org/10.1007/s13410-024-01347-z

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  • DOI: https://doi.org/10.1007/s13410-024-01347-z

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