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Role of serum pentraxin-3 levels in patients with and without diabetic nephropathy

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Background

Several studies have reported that increased pentraxin-3 (PTX3) levels are associated with impaired renal function in chronic kidney disease (CKD). PTX3 levels increase progressively with diabetic nephropathy (DN) and may be a biomarker for early diagnosis of DN.

Objective

The study evaluates serum PTX3 levels and their association with the development of DN. We also aim to find out whether serum PTX3 is a better marker than high-sensitive CRP (hs-CRP) for DN.

Methods

In this study, we evaluated serum PTX3 levels in 150 patients which were distributed into three groups that are 50 patients with DN, 50 patients with diabetes mellitus (DM) without DN and 50 controls (not any evidence of DM). DN patients were subdivided: 32 patients with microalbuminuria and 18 patients with macroalbuminuria. Serum PTX3 levels were evaluated using an enzyme-linked immunosorbent assay (ELISA) kit.

Results

DN group patients had a higher value of PTX3 (p < 0.001) as compared to DM without DN and control groups. hs-CRP levels were higher in DM without DN patients compared to DN patients and controls. PTX3 (p = 0.33) and hs-CRP (p = 0.10) levels among microalbuminuria and macroalbuminuria patients were statistically not significant.

Conclusion

This study concludes that serum PTX3 can be used as a diagnostic marker for DN before the development of apparent chronic kidney disease and PTX3 was found to be a better marker than hs-CRP for diagnosing DN.

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References

  1. Lin X, Xu Y, Pan X, Xu J, Ding Y, Sun X, et al. Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025. Sci Rep. 2020;10(1):14790. https://doi.org/10.1038/s41598-020-71908-9. (Internet).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, et al. IDF diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Research and Clinical Practice. 2021;183(109119):109119. https://doi.org/10.1016/j.diabres.2021.109119.

    Article  PubMed  Google Scholar 

  3. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010;87(1):4–14. https://doi.org/10.1016/j.diabres.2009.10.007. (Internet).

    Article  CAS  PubMed  Google Scholar 

  4. Gewurz H, Zhang XH, Lint TF. Structure and function of the pentraxins. CurrOpin Immunol. 1995;7(1):54–64. https://doi.org/10.1016/0952-7915(95)80029-8. (Internet).

    Article  CAS  Google Scholar 

  5. Nauta AJ, De Haij S, Bottazzi B, Mantovani A, Borrias MC, Aten J, et al. Human renal epithelial cells produce the long pentraxin PTX3. Kidney Int. 2005;67(2):543–53. https://doi.org/10.1111/j.1523-1755.2005.67111.x. (Internet).

    Article  CAS  PubMed  Google Scholar 

  6. Zhu H, Yu W, Xie Y, Zhang H, Bi Y, Zhu D. Association of pentraxin 3 gene polymorphisms with susceptibility to diabetic nephropathy. Med Sci Monit [Internet]. 2017;23:428–36.

    Article  CAS  PubMed  Google Scholar 

  7. Suliman ME, Yilmaz MI, Carrero JJ, Qureshi AR, Saglam M, Ipcioglu OM, et al. Novel links between the long pentraxin 3, endothelial dysfunction, and albuminuria in early and advanced chronic kidney disease. Clin J Am Soc Nephrol. 2008;3(4):976–85. https://doi.org/10.2215/CJN.03960907. (Internet).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Prasad RM, Bali A, Tikaria R. Microalbuminuria. [Updated 2023 May 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK563255/.

  9. Zelmanovitz T, Gerchman F, Balthazar AP, et al. Diabetic nephropathy Diabetol Metab Syndr. 2009;1:10. https://doi.org/10.1186/1758-5996-1-10.

    Article  CAS  PubMed  Google Scholar 

  10. Rodríguez-Gutiérrez R, Montori VM. Glycemic control for patients with type 2 diabetes mellitus: our evolving faith in the face of evidence. Circ Cardiovasc Qual Outcomes. 2016;9(5):504–12. https://doi.org/10.1161/circoutcomes.116.002901. (Internet).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Wang R, Zhang J, Hu W. Association of serum pentraxin 3 concentrations with diabetic nephropathy. J Investig Med. 2016;64(6):1124–7. https://doi.org/10.1136/jim-2016-000082. (Internet).

    Article  PubMed  Google Scholar 

  12. Uzun S, Ozari M, Gursu M, Karadag S, Behlul A, Sari S, et al. Changes in the inflammatory markers with advancing stages of diabetic nephropathy and the role of pentraxin-3. Ren Fail. 2016;38(8):1193–8. https://doi.org/10.1080/0886022x.2016.1209031. (Internet).

    Article  CAS  PubMed  Google Scholar 

  13. Dawood AA, Kamel MA, Omar TA. Study of serum pentraxin 3 level in patients with diabetic nephropathy. Egypt J Intern Med. 2020;32(1). https://doi.org/10.1186/s43162-020-00002-3.

  14. Al-Barshomy S, Mostafa ME, Shaker G, Wahab L. Serum and urinary pentraxin-3 levels in type 2 diabetes and its relation to diabetic nephropathy. Egypt J Intern Med. 2018;30(4):182. https://doi.org/10.4103/ejim.ejim_9_18. (Internet).

    Article  Google Scholar 

  15. El-Senosy F, Elwakeel ME, Mohamed RE. Study of pentraxin-3 as an early marker of diabetic nephropathy in type 2 diabetes mellitus. Int J Diabetes Res. 2018;7(3):41–9. https://doi.org/10.5923/j.diabetes.20180703.01.

    Article  Google Scholar 

  16. Mezil SA, Ghudhaib KK, Allawi AA. Evaluation of serum pentraxin 3 level in Iraqi patients with diabetic nephropathy. Biochem Cell Arch. 2018;18:2473–7.

    Google Scholar 

  17. Valente MJ, Rocha S, Coimbra S, Catarino C, Rocha PP, Bronze-da-Rocha E, et al. Long pentraxin 3 as a broader biomarker for multiple risk factors in end-stage renal disease: association with all-cause mortality. Mediators of Inflammation. 2019;2019:1–12.

    Article  Google Scholar 

  18. Zlibut A, Bocșan IC, Agoşton-Coldea L. Pentraxin-3 and endothelial dysfunction. Adv Clin Chem. 2019;1:163–79.

    Article  Google Scholar 

  19. Lestariningsih L, Hardisaputro S, Nurani A, Santosa D, Santoso G. High sensitivity C-reactive protein as a predictive of intima-media thickness in patients with end-stage renal disease on regular hemodialysis. Int J Gen Med. 2019;12:219–24. https://doi.org/10.2147/ijgm.s205506. (Internet).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Sjöberg B, Qureshi AR, Heimbürger O, Stenvinkel P, Lind L, Larsson A, et al. Association between levels of pentraxin 3 and incidence of chronic kidney disease in the elderly. J Intern Med. 2016;279(2):173–9. https://doi.org/10.1111/joim.12411. (Internet).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, Amrita Institute of Medical Sciences and Research Centre (AIMS), Amrita Viswavidyapeetham University, AIMS Ponekkara P.O, Kochi, 682 041, Kerala, India

    Ananyaa Dixit, Sumithra N. Unni, Sumitha Prabhu & Sajitha Krishnan PP

  2. Department of Biostatistics, Amrita Institute of Medical Sciences and Research Centre (AIMS), Amrita Viswavidyapeetham University, AIMS Ponekkara P.O, Kochi, 682 041, Kerala, India

    Greeshma C. Ravindran

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  1. Ananyaa Dixit
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  2. Sumithra N. Unni
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  3. Sumitha Prabhu
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  4. Sajitha Krishnan PP
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  5. Greeshma C. Ravindran
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Ananyaa Dixit and Sumithra N. Unni C. The first draft of the manuscript was written by Ananyaa Dixit, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Sumithra N. Unni.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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The authors declare no competing interests.

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Dixit, A., Unni, S.N., Prabhu, S. et al. Role of serum pentraxin-3 levels in patients with and without diabetic nephropathy. Int J Diabetes Dev Ctries (2024). https://doi.org/10.1007/s13410-024-01335-3

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