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The influence of CDKAL1 (rs7754840) gene polymorphism on susceptibility to gestational diabetes mellitus in pregnant women: a systematic review and meta-analysis

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Objective

Gene polymorphisms CDKAL1 (rs7754840) have been related to type 2 diabetes mellitus, which may partially define the common genetic background with gestational diabetes mellitus (GDM). The aim of this study is to investigate the association between CDKAL1 polymorphism and susceptibility to GDM.

Methods

In this study and meta-analysis, we conducted a systematic search in electronic databases such as PubMed, Web of Science, Scopus, Cochrane, EMBASE, and Google scholar. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the association between CDKAL1 (rs7754840) polymorphisms and susceptibility to GDM in four genetic models. Statistical analysis was performed by Comprehensive Meta-Analysis (CMA) v3.7z software.

Results

A total of 13,307 participants from 11 original study were included in this study. We identified a significant relationship between the CDKAL1 (rs7754840) gene polymorphism and GDM in the study population through allelic models (C vs. G: OR = 1.29, 95% CI = 1.16–1.44, p = 0.00), homozygous genetic models (CC vs. GC: OR = 1.50, 95% CI = 1.28–1.75, p = 0.00), recessive models (CC vs. GG + GC: OR = 0.67, 95% CI = 0.57–0.79, p = 0.00), and dominant genetic models (CC + GC vs. GG: OR = 1.35, 95% CI = 1.17–1.56, p = 0.00). On the contrary, there is no significant association between the CDKAL1 gene polymorphism and susceptibility to GDM in heterozygous models (GC vs. GG: OR = 1.01, 95% CI = 0.92–1.12, p = 0.82).

Conclusion

The results provided evidence that CDKAL1 (rs7754840) gene polymorphism is associated with the susceptibility of GDM in women.

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Data availability

Several studies have examined the association between the CDKAL1 gene polymorphism (rs7754840) and gestational diabetes susceptibility, which were included in the meta-analysis. More details can be found in Table 1.

The data can be accessed at the following addresses:

https://doi.org/10.1007/s00125-008-1196-4

https://doi.org/10.1371/journal.pone.0026953

https://doi.org/10.2337%2Fdb11-1034

https://doi.org/10.1089/dia.2014.0349

https://doi.org/10.18632/oncotarget.22999

https://doi.org/10.1371%2Fjournal.pone.0169781

https://doi.org/10.1186%2Fs13104-018-3288-7

https://doi.org/10.1038%2Fs41598-019-41605-3

https://doi.org/10.3389%2Ffendo.2021.628582

https://doi.org/10.1186/s13098-021-00782-w

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Acknowledgment

This study was not financially supported. We appreciate all researchers whose articles were used in this study.

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Authors and Affiliations

  1. Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Amir Hossein Mahdizade & Eskandar Taghizadeh

  2. Student Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran

    Seyed Sobhan Bahreiny, Mohammad-Navid Bastani & Mojtaba Aghaei

  3. Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran

    Mohammad Reza Dabbagh

  4. Department of Clinical Biochemistry, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran

    Fardin Ali Malayeri

  5. Department of Pharmaceutics, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Aryan YousefiFard

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  1. Amir Hossein Mahdizade
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Correspondence to Eskandar Taghizadeh.

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Mahdizade, A.H., Bahreiny, S.S., Bastani, MN. et al. The influence of CDKAL1 (rs7754840) gene polymorphism on susceptibility to gestational diabetes mellitus in pregnant women: a systematic review and meta-analysis. Int J Diabetes Dev Ctries (2023). https://doi.org/10.1007/s13410-023-01272-7

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