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The role of serum level of irisin in diabetic retinopathy

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Objective

Diabetes retinopathy (DR) is one of the top listed world health issues. Screening is usually advised for diabetic cases on a routine basis. However, there is only partial access to ophthalmologists in all parts of the world. Irisin is a myokine that is being investigated for this reason. Our study aims to assess the role of irisin in detecting DR.

Methods and materials

In a cross-sectional study, 140 diabetes cases, including 70 patients with diabetic retinopathy and 70 patients free from diabetic retinopathy, were enrolled. Demographic and anthropometric data were gathered, and the patients underwent physical examination. Also, microalbuminuria and serum irisin levels were assessed in both groups. The results were compared between the two study groups.

Results

Among the enrolled cases, 55 (39.28%) were men, and 85 (60.72%) were women. The disease duration (p = 0.016) and the serum level of HBA1c (p = 0.014) were significantly higher in the diabetic retinopathy group compared to the group free from diabetic retinopathy. Moreover, irisin was significantly higher in the patients free from diabetic retinopathy (p = 0.007).

Conclusion

Irisin may have value in screening diabetic retinopathy; however, further studies are needed for this proposal.

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Acknowledgements

We would like to thank all participants of this study for this research wouldn’t be possible without their commitment and patience during the process.

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Authors and Affiliations

  1. Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Zahra Mazloum Khorasani & Mina AkbariRad

  2. Department of Ophthalmology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Seyedeh Maryam Hosseini

  3. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Mohammadreza Safaei, Mehrdad Sarabi, Ashkan Torshizian & Niloofar Nikpasand

  4. Clinical Research Development Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Hassan Mehrad Majd

  5. Islamic Azad University, Mashhad Branch, Mashhad, Iran

    Nikoo Saeedi

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  1. Zahra Mazloum Khorasani
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  2. Seyedeh Maryam Hosseini
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Correspondence to Mina AkbariRad.

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The Mashhad University of Medical Sciences ethics committee fully approved the current research under the code: IR.MUMS.MEDICAL.REC.1397.599.

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Mazloum Khorasani, Z., Hosseini, S., Safaei, M. et al. The role of serum level of irisin in diabetic retinopathy. Int J Diabetes Dev Ctries (2023). https://doi.org/10.1007/s13410-023-01235-y

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