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The value of adenosine deaminase activity in latent autoimmune diabetes in adults and type 2 diabetes patients

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Abstract

Objective

Adenosine deaminase (ADA) associated with cell-mediated immune responses is involved in many diseases. But little is known about the value of ADA activity in the progression of different diabetes types. The purpose of this study was to compare the ADA level between latent autoimmune diabetes in adults (LADA), type 2 diabetes (T2D) patients, and healthy controls (HC) and analyze its correlation with glycemic parameters and systemic cytokines.

Methods

This hospital-based study included 28 LADA patients, 52 T2D patients, and 50 HC. Serum ADA activity and concentrations of inflammatory cytokines were measured. Correlations of ADA level with different indicators were assessed by using spearman’s correlation method.

Results

Serum ADA activity was significantly higher in T2D patients compared with LADA (p = 0.008) and HC (p < 0.001). Correlation analysis of ADA with HbA1c% (r = 0.34, p = 0.003) and inflammatory cytokines (IL-6, r = 0.31, p = 0.007; IL-10, r = 0.22, p = 0.049) showed significant positive correlations.

Conclusions

Serum ADA activity may reflect the different immunopathogenesis between LADA and T2D patients.

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Data availability

All the data on which the conclusions of the manuscript rely is presented in the main paper.

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Acknowledgments

The authors would like to thank the clinical and laboratory staff of the Zhejiang Provincial People’s Hospital, Hangzhou, China, for facilitating the collection and measurement of the blood samples.

Funding

The study was supported by the Zhejiang Provincial Medical and Health Research Foundation of China (2017KY006) and the National Natural Science Foundation of China (81902132).

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Authors and Affiliations

  1. Department of Clinical Laboratory, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Zhejiang, 310014, Hangzhou, China

    Yu Zhou, Wei-Dong Jin, Zhen-Zhen Pang, Jun Xia & Su-Feng Chen

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  1. Yu Zhou
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  2. Wei-Dong Jin
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  3. Zhen-Zhen Pang
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  4. Jun Xia
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Contributions

All authors contributed to the study conception and design. Yu Zhou, literature search and original draft preparation; Wei-Dong Jin, patients recruitment and samples collection; Zhen-Zhen Pang, data analysis and interpretation; Jun Xia, statistical analysis, manuscript preparation, and review; Su-Feng Chen, intellectual content definition, manuscript review, and final approval. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Yu Zhou.

Ethics declarations

This study was approved by the ethics committee of Zhejiang Provincial People’s Hospital (2020QT223).

Conflict of interest

The authors declare no competing interests.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Zhou, Y., Jin, WD., Pang, ZZ. et al. The value of adenosine deaminase activity in latent autoimmune diabetes in adults and type 2 diabetes patients. Int J Diabetes Dev Ctries 41, 48–53 (2021). https://doi.org/10.1007/s13410-020-00864-x

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  • DOI: https://doi.org/10.1007/s13410-020-00864-x

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