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Optimal reference values for insulin sensitivity indices in Iranian healthy females: a population-based study

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Purpose

To define reference values for various insulin sensitivity (IS) indices in healthy women in a population-based study of the five provinces in Iran

Methods

In this cross-sectional study, 250 normal-weighted women without hypertension, diabetes, polycystic ovary syndrome, hormonal disorders, pregnancy, or menopause were evaluated in this study. After a 12-h fasting, blood samples were obtained from all participants, levels of metabolic markers (fasting plasma glucose, lipid profile, insulin, etc.) were measured using enzymatic colorimetric and ultrasensitive enzyme-linked radioimmunoassay methods. Multiple insulin sensitivity indices were calculated using well-known predetermined formulas. K-means cluster analysis was used to determine reference values for each insulin sensitivity index.

Results

The threshold values of homeostasis model assessment (HOMA-%β, HOMA-βcell) and fasting insulin resistance index (FIRI) were 400.41, 198.55, and 2.57 corresponding to 97th, 93rd, and 92nd percentiles, respectively. Reference values of quantitative insulin sensitivity check index (QUICKI) and TG/HDL-c were 0.44 and 4.40, both of which relate to 92nd percentile. The recently introduced single-point insulin sensitivity estimator (SPISE) was analyzed and showed a threshold of 10.10 (87th percentile) in this study. Threshold values of reciprocal insulin (1/Insulin) and glucose-to-insulin ratio (G/I) were 0.51 (95th percentile) and 76.91 (99th percentile), respectively.

Conclusion

This study determined reference values for various insulin sensitivity indices in healthy Iranian women. These values can be used to define insulin sensitivity in women in epidemiological and clinical studies.

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Acknowledgments

This original study was based on a thesis for fulfillment of a Master of Public Health (M.P.H.) degree at the School of Public Health, Shahid Beheshti University of Medical Sciences. The authors would like to thank the staff of the Research Institute for Endocrine Sciences and those who have worked in the Iranian PCOS Prevalence Study. Also, the authors are also grateful to the unlimited support of the staff of the School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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Authors and Affiliations

  1. Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Fahimeh Ramezani Tehrani, Nazanin Hashemi, Seyed Ali Montazeri & Maryam Rahmati

  2. Department of Public Health, School of Public Health and Environmental and Occupational Hazards Control Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Hossein Hatami

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  1. Fahimeh Ramezani Tehrani
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Correspondence to Nazanin Hashemi.

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The authors declare that they have no conflict of interest.

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Informed written consents were obtained from all participants, and ethical review board of Research Institute for Endocrine Sciences approved the study protocol.

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Tehrani, F.R., Hashemi, N., Montazeri, S.A. et al. Optimal reference values for insulin sensitivity indices in Iranian healthy females: a population-based study. Int J Diabetes Dev Ctries 40, 591–596 (2020). https://doi.org/10.1007/s13410-020-00814-7

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  • DOI: https://doi.org/10.1007/s13410-020-00814-7

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