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HOMA-IR mean values in healthy individuals: a population-based study in iranian subjects

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Abstract

Purpose

Homeostasis Model Assessment-estimated Insulin Resistance (HOMA-IR) is an important indicator of insulin resistance. In this population-based investigation, we sought to report the mean value of HOMA-IR in different subgroups of a large population-based database of Iranian healthy subjects.

Methods

This study recruited adult healthy individuals between the ages of 18 to 70 years old to Massoud Medical Laboratory, Tehran, Iran. Fasting insulin was measured by using the Electro Chemiluminescence method using Roche Cobas 6000 e601/602 instrument.

Results

The mean ± SD value of the HOMA-IR index in the studied population was 2.11 ± 0.99 (2.5-97.5% percentiles: 0.66–4.50). In addition, the mean ± SD of HOMA-IR index in male and female groups were 2.35  1.0 (2.5-97.5 percentile: 0.57–4.37) and 2.05 ± 1.0 (2.5-97.5 percentiles: 0.53–4.35), respectively. Interestingly, it was observed a significant increment for the HOMA-IR index in the male group compared with the female group in all age subgroups (P < 0.01).

Conclusions

Our findings showed the mean value of 2.11 ± 0.99 HOMA-IR in the Iranian healthy population. Considering the large sample size in our study, more clinical investigations in terms of ethnicity should be done to provide a precise standardized HOMA-IR index in the Iranian population.

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Data Availability

The data and materials that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

The authors wish to thank the laboratory staff of Massoud Laboratory and all participants for their helpful enrollment.

Funding

Research work concerning the outputs presented in the manuscript and the Massoud Laboratory supported the manuscript creation, Confirmed proposal number: ML-99-1969-99109.

Author information

Authors and Affiliations

  1. Department of Biochemistry and Immunochemistry, Massoud Laboratory, Tehran, Iran

    Seyed Mohammad Masoodian, Abolfazl Omidifar, Sepideh Moradkhani & Majid Asiabanha

  2. Immunology Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Majid Khoshmirsafa

Authors
  1. Seyed Mohammad Masoodian
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  2. Abolfazl Omidifar
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  3. Sepideh Moradkhani
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  4. Majid Asiabanha
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Contributions

Planning of the study was performed with M.KH, M.M. and M.A. Conducting of the study was performed with M.KH, M.M. and M.A. Collecting of the data was carried out by M.KH and M.M, S.M and A.O Interpretation of data was carried out by M.KH and M.M, S.M and A.O. Drafting the manuscript was performed with M.KH, M.M. and M.A. All authors have approved the final draft and agreed to submit the manuscript to this journal.

Corresponding author

Correspondence to Majid Khoshmirsafa.

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Ethics approval and consent to participate

All participants signed an informed consent letter. We obtained ethical approval from the Massoud Laboratory (ML-99-1969).

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All authors support submission to this journal.

Competing interests

The authors declare that they have no competing interests.

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Masoodian, S.M., Omidifar, A., Moradkhani, S. et al. HOMA-IR mean values in healthy individuals: a population-based study in iranian subjects. J Diabetes Metab Disord 22, 219–224 (2023). https://doi.org/10.1007/s40200-022-01099-9

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  • DOI: https://doi.org/10.1007/s40200-022-01099-9

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