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TyG index and insulin resistance in beta-thalassemia

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Abstract

Insulin resistance (IR) underlies some glucose metabolism abnormalities in thalassemia major. Recently, triglyceride glucose index (TyG) has been proposed for evaluating insulin resistance as a simple, low cost, and accessible tool. In this study, the TyG index were studied for IR monitoring in beta-thalassemia major (βTM) patients. The participants were 90 βTM patients on chronic regular transfusion therapy. The TyG index was computed based on fasting plasma glucose (FPG) and triglyceride (TG). The time gap between the first and the second TyG index survey (TyG.1 and TyG.2) was 2 years. The agreement between TyG and HOMA-IR were studied with the extension of limit of agreement (LOA). We included 90 patients 53.3 % men (n = 48). Among them, 14.4 % (14.6 % male, 14.3 % female) had impaired fasting glucose level (e.g., 100–125 mg/dl) at first test. It rose to 37.8 % (27.1 % male, 50 % female) during 2 years. Based on TyG.1, the 34.4 % of patients was detected as IR cases. After 2 years, the percent of IR based on TyG.2 was 82.2 %. The mean differences between TyG.1 and TyG.2 and their differences from the considered cutoff values were significant (P < 0.001). The prediction limits between TyG and HOMA-IR had good agreement. These data may suggest the use of TyG index for detection/monitoring of IR in βTM patients.

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Acknowledgments

We thank the Golestan University of Medical Sciences for supporting the study setup. We would like to thank all the subjects for their participation and continued follow-up. The authors wish to thank all the survey personnel and the officers in Taleghani Pediatric hospital for their cooperation.

Funding

Deputy of research and technology of Golestan University of Medical Sciences

Conflict of interest

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Shahid Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

    Mohsen Jamshir

  2. Department of Biostatistics, Faculty of Paramedical, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mohammad Fayaz

  3. Hematology and Oncology Research Center, Golestan University of Medical Sciences, Gorgan, Iran

    Narges Mirbehbahani

  4. Department of Physiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

    S. Mehran Hosseini

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  1. Mohsen Jamshir
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  2. Mohammad Fayaz
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  3. Narges Mirbehbahani
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  4. S. Mehran Hosseini
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Correspondence to S. Mehran Hosseini.

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Jamshir, M., Fayaz, M., Mirbehbahani, N. et al. TyG index and insulin resistance in beta-thalassemia. Int J Diabetes Dev Ctries 35 (Suppl 3), 529–534 (2015). https://doi.org/10.1007/s13410-015-0418-9

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  • DOI: https://doi.org/10.1007/s13410-015-0418-9

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