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Gold nanoparticles with amyloid-β reduce neurocell cytotoxicity for the treatment and care of Alzheimer’s disease therapy

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A Correction to this article was published on 24 July 2023

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Abstract

Protein oligomerization contributes to Alzheimer’s disease development (AD). A nanoparticle that can speed up the oligomerization of proteins is generally considered harmful. Gold nanoparticles (AuNPs) have been reported to be making headway in biological platforms, but they may also have the capacity to stimulate protein oligomerization. Our goal herein was to investigate the neurotoxicity and oligomerization of amyloid-β-1-42 (Aβ1-42) in the presence of AuNPs. The precipitation approach was used to create AuNPs, which were then analyzed using transmission electron microscopy (TEM), ThT, Congo red, and CD spectroscopy. The results demonstrated that the 50-nm-sized fabricated AuNPs guided acceleration in Aβ1-42. In addition, cytotoxicity studies on PC 12 cells showed that Aβ1-42 with AuNPs were less toxic than untreated oligomers Aβ1-42 in terms of inducing cell death, oxidative apoptosis, stress, and membrane leakage. In conclusion, our investigation sheds light on how AuNPs stimulate the development of cytotoxic oligomers by binding to proteins in Alzheimer’s disease.

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Data availability

The datasets used and analyzed during the current study are available from the corresponding author upon request.

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Authors and Affiliations

  1. Department of Neurology, The First People’s Hospital of Wenling, No.333, Chuanan South Road, Chengxi Street, Wenling, 317500, China

    Qing Hong, Xinchun Jin, Chenheng Zhou & Jiahui Shao

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  1. Qing Hong
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  2. Xinchun Jin
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Correspondence to Jiahui Shao.

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Hong, Q., Jin, X., Zhou, C. et al. Gold nanoparticles with amyloid-β reduce neurocell cytotoxicity for the treatment and care of Alzheimer’s disease therapy. Gold Bull 56, 135–144 (2023). https://doi.org/10.1007/s13404-023-00327-1

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