Abstract
Owing to their highly interesting applications in medicine, catalysis, and their luminescence properties, over the past decade, increasing efforts have been devoted to the synthesis of organo-gold(III) complexes. Therefore, the design of mild, practical, and modular protocols for their synthesis is a highly active field of research. In a recent paper in Angewandte Chemie, Hashmi and co-workers developed an efficient and solvent-free method for the mechanochemical synthesis of differently organo-gold(III) complexes; this method opens up a new perspective for the field.
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References
Rocchigiani L, Bochmann M (2021) Recent advances in gold(III) chemistry: structure, bonding, reactivity, and role in homogeneous catalysis. Chem Rev 121:8364–8451
Bertrand B, Williams MRM, Bochmann M (2018) Gold(III) complexes for antitumor applications: an overview. Chem Eur J 24:11840–11851
Kumar R, Nevado C (2017) Cyclometalated gold(III) complexes: synthesis, reactivity, and physicochemical properties. Angew Chem Int Ed 56:1994–2015
Joost M, Amgoune A, Bourissou D (2015) Reactivity of gold complexes towards elementary organometallic reactions. Angew Chem Int Ed 54:15022–15045
Tsai JL-L, Chan AO-Y, Che C-M (2015) A luminescent cyclometalated gold(III)-avidin conjugate with a long-lived emissive excited state that binds to proteins and DNA and possesses anti-proliferation capacity. Chem Commun 51:8547–8550
Tang M-C, Leung M-Y, Lai S-L, Ng M, Chan M-Y, Yam VW-W (2018) Realization of thermally stimulated delayed phosphorescence in arylgold(III) complexes and efficient gold(III) based blue-emitting organic light-emitting devices. J Am Chem Soc 140:13115–13124
Wong K-H, Cheung K-K, Chan MC-W, Che C-M (1998) Application of 2,6-diphenylpyridine as a tridentate [C^N^C] dianionic ligand in organogold(III) chemistry. structural and spectroscopic properties of mono- and binuclear transmetalated gold(III) complexes. Organometallics 17:3505–3511
Eppel D, Rudolph M, Rominger F, Hashmi ASK (2020) Mercury-free synthesis of pincer [C^N^C]AuIII complexes by an oxidative addition/CH activation cascade. Chemsuschem 13:1986–1990
Yam VW-W, Wong KM, Hung LL, Zhu N (2005) Luminescent gold(III) alkynyl complexes: synthesis, structural characterization, and luminescence properties. Angew Chem Int Ed 44:3107–3110
Ros D-A, ¸ Smith D A, Bochmann M, (2012) Cyclometallated gold(III) hydroxides as versatile synthons for Au-N, Au-C complexes and luminescent compounds. Chem Commun 48:7247–7249
Eppel D, Eryiğit A, Rudolph M, Brückner M, Rominger F, Asiri AM, Hashmi ASK (2021) Mechanochemical gold(III)-carbon bond formation. Angew Chem Int Ed 60:13636–13640
Witzel S, Holmsen MSM, Rudolph M, Dietl MC, Ødegaard-Øien S, Rominger F, Tilset M, Hashmi ASK (2020) Simple mercury-free synthesis and characterization of symmetric and unsymmetric mono- and dialkynyl (tpy)Au(III) complexes. Organometallics 39:2830–2837
Au VKM, Wong KMC, Zhu N, Yam VWW (2011) Luminescent cyclometalated dialkynylgold(III) complexes of 2-phenylpyridine-type derivatives with readily tunable emission properties. Chem Eur J 17:130–142
Garg JA, Blacque O, Venkatesan K (2011) Syntheses and photophysical properties of luminescent mono-cyclometalated gold(III) cis-dialkynyl complexes. Inorg Chem 50:5430–5441
Hashmi ASK (2007) Gold-Catalyzed organic reactions. Chem Rev 107:3180–3211
Pažický M, Loos A, Ferreira MJ, Rominger F, Jäkel C, Hashmi ASK, Limbach M (2010) Synthesis, reactivity, electrochemical studies of Au(I) and Au(III) complexes supported by N-heterocyclic carbenes and their application in catalysis. Organometallics 29:4448–4458
Zeng Z, Jin H, Rudolph M, Rominger F, Hashmi ASK (2018) Gold(III)-catalyzed site-selective and divergent synthesis of 2-aminopyrroles and quinoline-based polyazaheterocycles. Angew Chem Int Ed 57:16549–16553
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Hu, C. Organo-gold(III) complexes via mechanochemistry in a ball mill. Gold Bull 55, 15–18 (2022). https://doi.org/10.1007/s13404-021-00302-8
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DOI: https://doi.org/10.1007/s13404-021-00302-8