Abstract
The detection of biomarkers in blood macrophages is a new non-invasive cancer screening method, but its performance in early stage lung cancer screening remains undetermined. We evaluated the Apo10 and TKTL1 levels in blood macrophages of 156 early-stage lung cancer patients and 153 controls. APT (combination of Apo10 and TKTL1) level was significantly higher in the lung cancer group than that in the control group (P < 0.001). AUROC analysis showed that APT has high diagnostic value in differentiating early-stage lung cancer (AUC = 0.9132) and can be considered a biomarker for screening lung cancer patients from individuals with lung nodules.
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Data Availability
Chuanbo Xie, Yuying Liu, and Musheng Zeng had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. The data used for the analyses are available by request to the corresponding author (Chuanbo Xie).
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Acknowledgements
The authors acknowledge the participants who participated in this diagnostic study. Registration of this study ChiCTR2000040302.
Funding
This study was supported by the Guangdong Basic and Applied Basic Research Foundation (2022A1515011329).
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Chuanbo Xie, Shuqing Wang, Yuying Liu and Chi Guo were responsible for data acquisition and analysis. Chuanbo Xie was responsible for preparing the first draft of the manuscript. Chuanbo Xie and Yuying Liu were responsible for recruiting study participants. Chi Guo was responsible for Apo10 and TKTL1 testing. Musheng Zeng supported the study design development and interpretation of the data. All authors had an opportunity to review and revise the manuscript and approved its final submitted version.
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This study was approved by the institutional review board of Sun Yat-sen University Cancer Center (SYSUCC, ID: G2022-005-01), and all procedures were conducted according to the principles expressed in the Declaration of Helsinki. The authors enrolled the participants using a chart review blinded to their personal identifying information (name, address, etc.). Therefore, this study did not violate the right and welfare of the subjects. All participants provided written consent for the anonymous use of their data for their research purposes.
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Xie, C., Wang, S., Guo, C. et al. Apo10 and TKTL1 in blood macrophages as biomarkers for differentiating lung cancer from benign lung lesions: a comparative study with conventional biomarkers. Cell Oncol. 46, 1725–1729 (2023). https://doi.org/10.1007/s13402-023-00838-1
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DOI: https://doi.org/10.1007/s13402-023-00838-1