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Analysis of chemical composition and biological efficiency of leaf essential oils isolated from seven species of Cinnamomum of the Western Ghats, India

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Abstract

The chemical profiles of essential oils (EOs) of 7 Cinnamomum species (C. sulphuratum, C. perotettii, C. verum, C. wightii, C. camphora, C. glanduliferum, and C. malabatrum) composed from assorted parts of Western Ghats were analyzed. The antioxidant, antibacterial, and larvicidal potentialities of 7 essential oils were also investigated. Cinnamomum verum was observed to have the maximum yield (1.96%) of EO followed by C. malabatrum (1.71%). GC-MS analysis of EOs reported the highest amount of eugenol (38.04%), shyobunol (13.31%) in C. verum, whereas C. perrottetii identified 14–42 phytocompounds including terpenes, sesquiterpenes, monoterpenes, diterpenes, and phenylpropanoids, esters, aldehydes, and fatty acids. In the antibacterial activity, the higher zone of inhibition of C. malabatrum showed against S. pyogenes (28 ± 2.5 mm) and E. faecalis (27 ± 1.24 mm) followed by C. verum has shown notable inhibition zone against K. pneumoniae (26 ± 1.15 mm) and S. flexneri (24.33 ± 0.88 mm), with MIC value against C. verum, showed MIC value (1.17 ± 0.34 μg/mL) against S. flexneri, S. pyogenes, and K. pneumonia. All the Cinnamomum oil samples exhibited appreciable antioxidant radical scavenging activities with IC50 values ranged 10.83–15.06 μg/mL. All the oil samples showed promising larvicidal activity against the late-third instar larvae of Aedes aegypti. Extending the present study with in vivo and in vitro animal studies will confirm the potentiality of Cinnamomum oils in the field of biomedicine to detect novel medicines.

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Funding

We thank the National Medicinal Plant Board, New Delhi for providing financial support through a major research project (F.No. Z. 18017/187/CSS/ R&D/TN-01/2023-24- NMPB-IV A).

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  1. Department of Biology, The Gandhigram Rural Institute (Deemed to be University), Gandhigram, Dindigul, Tamil Nadu, 624302, India

    Saranya Surendran, Smija KP & Raju Ramasubbu

  2. Centre for Applied Research, Institute of Biotechnology, Saveetha School of Engineering (SSE), Saveetha Institute of Technical and Medical Sciences (SIMATS), Saveetha University, Thandalam, Chennai, Tamil Nadu, 602105, India

    Arjun Pandian

  3. Natural Products & Nanobiotechnology Research Lab, Department of Community Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), (Saveetha University), Thandalam, Chennai, Tamil Nadu, 600105, India

    Azhagu Madhavan Sivalingam

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Saranya Surendran; execution of laboratory studies, preparation of the manuscript; Smija, K.P: execution and assistance of laboratory studies; Raju Ramasubbu: planning of research problem, work designed, lead, review and editing of the manuscript, Azhagu Madhavan Sivalingam and Arjun Pandian reviewed, edited revised article.

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Surendran, S., KP, S., Pandian, A. et al. Analysis of chemical composition and biological efficiency of leaf essential oils isolated from seven species of Cinnamomum of the Western Ghats, India. Biomass Conv. Bioref. (2024). https://doi.org/10.1007/s13399-024-05653-8

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