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Layered Double Hydroxides Nanohybrid Intercalation with Folic Acid Used as Delivery System and their Controlled Release Properties

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Abstract

For fully controlled drug release, it is important to completely understand the microstructure and nature of the layered double hydroxide that ultimately controls drug release properties. The anion of folic acid (FA) as an organic guest was intercalated into the interlayer of anionic clay, Ni/Al hydrotalcite-like or layered double hydroxides (LDHs) as host by direct co-precipitation method from aqueous solution for the formation of new nanohybrid compound, Ni/Al–FA nanohybrids (NAHs), where, Ni/Al molar ratio R = 3 and concentration of folic acid (FA) (100 ppm) were used for the synthesis. Accumulations of 88, 78 and 72 %, as release profiles of the guest anion in carbonate, phosphate and sulphate media have been conducted, in all these media the release was governed by pseudo-second order model of kinetics. In this study, novel equations were innovated that used the prediction of diffusion of guest anion through LDHs nanohybrid particles and applied it for folic acid release. These equations were more suitable for diffusion than the previous equations such as (Bhaskar equation, the parabolic diffusion model, the modified Freundlich model etc.) and it is the best and convenient.

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References

  1. Liu Z., Ma R., Osada M., Iyi N., Ebina Y., Takada K., Sasaki T.: Synthesis, anion exchange, and delamination of Co-Al layered double hydroxide: assembly of the exfoliated nanosheet/polyanion composite films and magneto-optical studies. J. Am. Chem. Soc. 128, 4872–4880 (2006)

    Article  Google Scholar 

  2. Shi W., Wei M., Lu J., Li F., He J., Evans D.G., Duan X.: Molecular orientation and fluorescence studies on naphthalene acetate intercalated Zn2Al layered double hydroxide. J. Phys. Chem. C 112, 19886–19895 (2008)

    Article  Google Scholar 

  3. Violante A., Pucci M., Cozzolino V., Zhu J., Pigna M.: Sorption/desorption of arsenate on/from Mg–Al layered double hydroxides: influence of phosphate. J. Colloid Interf. Sci 333, 63–70 (2009)

    Article  Google Scholar 

  4. Choy J.-H., Kawak S.-Y., Park J.-S., Jeong Y.-J., Portier J.: Intercalative nanohybrids of nucleoside monophosphates and DNA in layered metal hydroxide. J. Am. Chem. Soc. 121, 1399–1400 (1999)

    Article  Google Scholar 

  5. Thyveetil M.-A., Coveney P.V., Greenwell H.C., Suter J.L.: Computer simulation study of the structural stability and materials properties of DNA-intercalated layered double hydroxides. J. Am. Chem. Soc. 130, 4742–4756 (2008)

    Article  Google Scholar 

  6. Oh J.-M., Kwak S.-Y., Choy J.-H.: Intracrystalline structure of DNA molecules stabilized in the layered double hydroxide. J. Phys. Chem. Solids 67, 1028–1031 (2006)

    Article  Google Scholar 

  7. Newman S.P., Cristina T.D., Coveney P.V.: Molecular dynamics simulation of cationic and anionic clays containing amino acids. Langmuir 18, 2933–2939 (2002)

    Article  Google Scholar 

  8. Yuan Q., Wei M., Evans D.G., Duan X.: Preparation and investigation of thermolysis of L-aspartic acid-intercalated layered double hydroxide. J. Phys. Chem. B 108, 12381–12387 (2004)

    Article  Google Scholar 

  9. Hibino T.: Delamination of layered double hydroxides containing amino acids. Chem. Mater. 16, 5482–5488 (2004)

    Article  Google Scholar 

  10. Aisawa, S., Takahashi, S., Ogasawara, W., Umetsu, Y., Narita, E.: Direct intercalation of amino acids into layered double hydroxides by coprecipitation. J. Solid State Chem. 162, 52–62 (2001)

    Google Scholar 

  11. Nakayama, H., Wada, N., Tsuhako, M.: Intercalation of amino acids and peptides into Mg-Al layered double hydroxide by reconstruction method. Int. J. Pharm. 269, 469–478 (2004)

    Google Scholar 

  12. Gasser, M.S.: Inorganic layered double hydroxides as ascorbic acid (vitamin c) delivery system-intercalation and their controlled release properties. Colloids Surf. B 73, 103–109 (2009)

    Google Scholar 

  13. Choy, J.-H., Son, Y.-H.: Intercalation of vitamer into LDH and their controlled release properties. Bull. Korean Chem. Soc. 25, 122–126 (2004)

    Google Scholar 

  14. Rachmawati, H., Rasaputri, D.H., Tarini, S.: Preparation and characterization of folic acid-encapsulated solid lipid nanoparticle. J. Nano Saintek 3, 37–40 (2010)

    Google Scholar 

  15. Park, M., Lee, C.-I., Seo, Y.J., Woo, S.R., Shin, D., Choi, J.: Hybridization of the natural antibiotic, cinnamic acid, with layered double hydroxides (LDH) as green pesticide. Environ. Sci. Pollut. Res. 17, 203–209 (2010)

    Google Scholar 

  16. Inacio, J., Taviot-Guého, C., Forano, C., Besse, J.P.: Adsorption of MCPA pesticide by MgAl-layered double hydroxides. Appl. Clay Sci. 18, 255–264 (2001)

    Google Scholar 

  17. Li, F., Wang, Y., Yang, Q., Evans, D.G., Forano, C., Duan, X.: Study on adsorption of glyphosate (N-phosphonomethyl glycine) pesticide on MgAl-layered double hydroxides. J. Hazard. Mater. 125, 89–95 (2005)

    Google Scholar 

  18. Chaara, D., Pavlovic, I., Bruna, F., Ulibarri, M.A., Draoui, K., Barriga, C.: Removal of nitrophenol pesticides from aqueous solutions by layered double hydroxides and their calcined products, Appl. Clay Sci. 50, 292–298 (2010)

    Google Scholar 

  19. Hussein, M.Z., Yahaya, A.H., Zainal, Z., Kian, L.H.: Nanocomposite-based controlled release formulation of an herbicide, 2,4-dichlorophenoxyacetate incapsulated in zinc–aluminium-layered double hydroxide. Sci. Technol. Adv. Mater. 6, 956–962 (2005)

    Google Scholar 

  20. Hussein, M.Z., Zainal, Z., Yahaya, A.H., Foo, D.W.: Controlled release of a plant growth regulator, a-naphthaleneacetate from the lamella of Zn-Al-layered double hydroxide nanocomposite. J. Control. Release 82, 417–427 (2002)

    Google Scholar 

  21. Jung H., Kim H.-M., Choy Y.B., Hwang S.-J., Choy J.-H.: Itraconazole–Laponite: Kinetics and mechanism of drug release, Appl. Clay Sci. 40, 99–107 (2008)

    Google Scholar 

  22. Xu, Z.P., (Max) Lu, G.Q.: Layered double hydroxide nanomaterials as potential cellular drug delivery agents. Pure Appl. Chem. 78, 1771–1779 (2006)

    Google Scholar 

  23. Wang, J., Liu, Q., Zhang, G., Li, Z., Yang, P., Jing, X., Zhang, M., Liu, T., Jiang, Z.: Synthesis, sustained release properties of magnetically functionalized organic-inorganic materials: amoxicillin anions intercalated magnetic layered double hydroxides via calcined precursors at room temperature. Solid State Sci. 11, 1597–1601 (2009)

    Google Scholar 

  24. Alexa, I.F., Popovici, R.F., Ignat, M., Popovici, E., Voicu, V.A.: Non-toxic nanocomposite containing captopril intercalated into green inorganic carrier. Dig. J. Nanomater. Biosci. 6, 1091–1101 (2011)

    Google Scholar 

  25. Zhang, H., Zou, K., Guo, S., Duan, X.: Nanostructural drug-inorganic clay composites: structure, thermal property and in vitro release of captopril-intercalated Mg-Al-layered double hydroxides. J. Solid State Chem. 179, 1792–1801 (2006)

    Google Scholar 

  26. Choy, J.-H., Jung, J.-S., Oh, J.-M., Park, M., Jeong, J., Kang, Y.-K., Han, O.-J.: Layered double hydroxide as an efficient drug reservoir for folate derivatives. Biomater. 25, 3059–3064 (2004)

    Google Scholar 

  27. Xiao R., Wang W., Pan L., Zhu R., Yu Y., Li H., Liu H., Wang S.-L.: A sustained folic acid release system based on ternary magnesium/zinc/aluminum layered double hydroxides. J. Mater. Sci. 46, 2635–2643 (2011)

    Article  Google Scholar 

  28. Qin L., Wang S., Zhang R., Zhu R., Sun X., Yao S.: Two different approaches to synthesizing Mg–Al-layered double hydroxides as folic acid carriers. J. Phys. Chem. Solids 69, 2779–2784 (2008)

    Article  Google Scholar 

  29. Flesken-Nikitin, A., Toshkov, I., Naskar, J., Tyner, K.M., Williams, R.M., Zipfel, W.R., Giannelis, E.P., Nikitin, A.Y.: Toxicity and biomedical imaging of layered nanohybrids in the mouse. Toxicol. Pathol. 35, 804–810 (2007)

    Google Scholar 

  30. Kwak, S.-Y., Jeong, Y.-J., Park, J.-S., Choy, J.-H.: Bio-LDH nanohybrid for gene therapy. Solid State Ionics 151, 229–234 (2002)

    Google Scholar 

  31. Pan, D., Zhang, H., Zhang, T., Duan, X.: A novel organic–inorganic microhybrids containing anticancer agent doxifluridine and layered double hydroxides: structure and controlled release properties. Chem. Eng. Sci. 3762–3771 (2010)

  32. Hussein, M.Z., Jaafar, A.M., Yahaya, A.H., Zainal, Z.: The effect of single, binary and ternary anions of chloride, carbonate and phosphate on the release of 2,4-dichlorophenoxyacetate intercalated into the Zn–Al-layered double hydroxide nanohybrid. Nanoscale Res. Lett. 4, 1351–1357 (2009)

    Google Scholar 

  33. Jubri, Z., Hussein, M.Z., Yahaya, A.H., Zainal, Z., Sarijo, S.H.: Development of controlled drug release formulation based on pamoate-zinc-aluminium-layered double hydroxide nanocomposite. Malays. J. Anal. Sci. 12, 491–499 (2008)

    Google Scholar 

  34. Hussein, M.Z., Jaafar, A.M., Yahaya, A.H., Zainal, Z.: Inorganic-based phytohormone delivery vector of 2-chloroethylphosphonate nanohybrid: a new stimulating compound with controlled release property to increase latex production. J. Exp. Nanosci. Malays. 5, 310–318 (2010)

    Google Scholar 

  35. Bhaskar R., Murthy R.S.R., Miglani B.D., Viswanathan K.: Novel method to evaluate diffusion controlled release of drug from resinate. Int. J. Pharm. 28, 59–66 (1986)

    Article  Google Scholar 

  36. Ruckebusch C., Sombret B., Froidevaux R., Huvenne J.-P.: On-line mid-infrared spectroscopic data and chemometrics for the monitoring of an enzymatic hydrolysis. Appl. Spectrosc. 55, 1610–1617 (2001)

    Article  Google Scholar 

  37. Alcazar A., Pablos F., Martn M.J., Gonzalez A.G.: Multivariate characterisation of beers according to their mineral content. Talanta 57, 45–52 (2002)

    Article  Google Scholar 

  38. Celikoglu H.B.: Application of radial basis function and generalized regression neural networks in non-linear utility function specification for travel mode choice modeling. Math. Comput. Model. 44, 640–658 (2006)

    Article  MATH  Google Scholar 

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Authors and Affiliations

  1. Chemistry Department, Kerbala University, Kerbala, Iraq

    Abbas M. Bashi, Salih M. Haddawi & Mohammed Adnan Mezaal

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  1. Abbas M. Bashi
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  2. Salih M. Haddawi
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  3. Mohammed Adnan Mezaal
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Correspondence to Abbas M. Bashi.

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Bashi, A.M., Haddawi, S.M. & Mezaal, M.A. Layered Double Hydroxides Nanohybrid Intercalation with Folic Acid Used as Delivery System and their Controlled Release Properties. Arab J Sci Eng 38, 1663–1680 (2013). https://doi.org/10.1007/s13369-012-0403-2

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  • DOI: https://doi.org/10.1007/s13369-012-0403-2

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