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The EGF epidermal growth factor counteracts Tat modulation of human endogenous retroviruses of the W family in astrocytes

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Abstract

Human astrocyte cells were exposed to HIV-Tat and/or epidermal growth factor (EGF), to monitor the expression of the neuropathogenic MSRV and Syncytin-1 elements of the HERV-W family of endogenous retroviruses and of TNFα. The results indicate that EGF counteracts Tat regulation of HERV-W/MSRVenv/Syncytin-1, throughout EGFR activation; this effect occurs by interfering with the induction of TNFα production by Tat. The novel effect of EGF counteraction of Tat-mediated regulation of the neuropathogenic HERV-Ws could be neuro-protective, but its actual role in the brain remains to be elucidated.

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Acknowledgements

The study was supported in part by grants from CARITRO, grant 2013.0248 and RAS LR-2012, grant CRP-59781. EU was supported by a research fellowship of CARITRO 2013.

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  1. Department of Biomedical Sciences, University of Sassari, viale San Pietro 43B, 07100, Sassari, Italy

    Elena Uleri, Claudia Piu, Maurizio Caocci, Gabriele Ibba, Caterina Serra & Antonina Dolei

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  1. Elena Uleri
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  2. Claudia Piu
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  3. Maurizio Caocci
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  4. Gabriele Ibba
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Correspondence to Antonina Dolei.

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Uleri, E., Piu, C., Caocci, M. et al. The EGF epidermal growth factor counteracts Tat modulation of human endogenous retroviruses of the W family in astrocytes. J. Neurovirol. 23, 587–592 (2017). https://doi.org/10.1007/s13365-017-0531-2

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  • DOI: https://doi.org/10.1007/s13365-017-0531-2

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