The EGF epidermal growth factor counteracts Tat modulation of human endogenous retroviruses of the W family in astrocytes

  • Elena Uleri
  • Claudia Piu
  • Maurizio Caocci
  • Gabriele Ibba
  • Caterina Serra
  • Antonina Dolei
Short Communication

DOI: 10.1007/s13365-017-0531-2

Cite this article as:
Uleri, E., Piu, C., Caocci, M. et al. J. Neurovirol. (2017). doi:10.1007/s13365-017-0531-2
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Abstract

Human astrocyte cells were exposed to HIV-Tat and/or epidermal growth factor (EGF), to monitor the expression of the neuropathogenic MSRV and Syncytin-1 elements of the HERV-W family of endogenous retroviruses and of TNFα. The results indicate that EGF counteracts Tat regulation of HERV-W/MSRVenv/Syncytin-1, throughout EGFR activation; this effect occurs by interfering with the induction of TNFα production by Tat. The novel effect of EGF counteraction of Tat-mediated regulation of the neuropathogenic HERV-Ws could be neuro-protective, but its actual role in the brain remains to be elucidated.

Keywords

Epidermal growth factor (EGF) HERV-W/MSRV/Syncytin-1 human endogenous retroviruses Tat NeuroAIDS/neuropathogenicity Tumor necrosis factor-α (TNFα) Epidermal growth factor receptor (EGFR) 

Copyright information

© Journal of NeuroVirology, Inc. 2017

Authors and Affiliations

  1. 1.Department of Biomedical SciencesUniversity of SassariSassariItaly

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