The EGF epidermal growth factor counteracts Tat modulation of human endogenous retroviruses of the W family in astrocytes
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- Uleri, E., Piu, C., Caocci, M. et al. J. Neurovirol. (2017). doi:10.1007/s13365-017-0531-2
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Human astrocyte cells were exposed to HIV-Tat and/or epidermal growth factor (EGF), to monitor the expression of the neuropathogenic MSRV and Syncytin-1 elements of the HERV-W family of endogenous retroviruses and of TNFα. The results indicate that EGF counteracts Tat regulation of HERV-W/MSRVenv/Syncytin-1, throughout EGFR activation; this effect occurs by interfering with the induction of TNFα production by Tat. The novel effect of EGF counteraction of Tat-mediated regulation of the neuropathogenic HERV-Ws could be neuro-protective, but its actual role in the brain remains to be elucidated.