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Pharmacokinetics of vitexin-4″-O-glucoside in rats after intravenous application

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Abstract

Vitexin-4″-O-glucoside (VOG), being a main component in the leaves of Crataegus pinnatifida Bge. var. major, was isolated and then three different doses (20, 40, and 60 mg/kg) of VOG were administered intravenously to rats. To study its pharmacokinetics, a simple and rapid HPLC method was developed using hesperidin as internal standard and the relative parameters were calculated by both compartmental and non-compartmental approach. The results showed that VOG fitted a two-compartment open model. The values of AUC increased proportionally within the range of 20–60 mg/kg. Additionally, α half-life, β half-life, aCL, MRT0→t , MRT0→∞ , and terminal half-life of VOG in rats showed significant differences between 20 mg/kg and other doses. Thereby, VOG presented a dose-dependent pharmacokinetics in the range of 20–60 mg/kg and non-linear pharmacokinetics at lower dose.

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Acknowledgment

This study was supported by the Natural Science Foundation of Liaoning Province (20072073), China.

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Authors and Affiliations

  1. School of Pharmacy, Liaoning University of Traditional Chinese Medicine, 77 Shengming 1 Road, DD Port, Dalian, 116600, China

    Xi Xiang Ying, Fei Wang, Zhong Zhe Cheng, Wen Jie Zhang, Yang Du, Xun Liu, Si Yuan Wang & Ting Guo Kang

  2. School of Basic Medical Sciences, Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, China

    Hai Bo Li

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  1. Xi Xiang Ying
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  2. Fei Wang
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  7. Xun Liu
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Correspondence to Ting Guo Kang.

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Ying, X.X., Wang, F., Cheng, Z.Z. et al. Pharmacokinetics of vitexin-4″-O-glucoside in rats after intravenous application. Eur J Drug Metab Pharmacokinet 37, 109–115 (2012). https://doi.org/10.1007/s13318-011-0071-8

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  • DOI: https://doi.org/10.1007/s13318-011-0071-8

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