Abstract
Objective
To analyse the clinical and radiological characteristics of pituitary stalk interruption syndrome (PSIS).
Methods
A retrospective analysis of confirmed cases of PSIS was performed. The development of new pituitary hormonal deficiencies and response to recombinant human growth hormone (rhGH) therapy were assessed during follow-up.
Results
This study included 14 children (10 boys) of PSIS with median (range) age of 12.15 years (2 months–18 years). Short stature was the most common presentation (n = 13), and micropenis (n = 4), cleft lip (n = 1) and single central incisor (n = 1) were other midline defects. Growth hormone (GH) deficiency was present in 14 children and 7 of them also had multiple pituitary hormone deficiencies at baseline. Central hypothyroidism (n = 5), secondary adrenal deficiency (n = 4) and gonadotropin deficiencies (n = 2) were also seen. All children received rhGH. The mean height gain on follow-up was 12.78 cm in first year (n = 14), 6.5 cm in second year (n = 8) and 4.07 cm in third year (n = 7) of rhGH therapy. Four children developed additional pituitary hormone deficiency on follow-up.
Conclusion
Short stature with isolated GH deficiency was the most common presentation of PSIS that showed good response to rhGH therapy.
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Contributors: All the authors were involved in work conception, data acquisition, data analysis and interpretation of data, drafting and revision of manuscript.
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Ethical clearance: Institute Ethics Committee, Gauhati Medical College; No. MC 190/2007/Pt-II/April-2023/17, dated June 23, 2023.
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Ravichandran, R., Saikia, U.K., Bhuyan, A.K. et al. Pituitary Stalk Interruption Syndrome: Analysis of Response to Growth Hormone Therapy. Indian Pediatr 61, 154–157 (2024). https://doi.org/10.1007/s13312-024-3111-6
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DOI: https://doi.org/10.1007/s13312-024-3111-6