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Change in Apo B100/A1 Ratio in Children With Epilepsy on Monotherapy With Sodium Valproate, Oxcarbazepine or Levetiracetam

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Abstract

A prospective longitudinal study was conducted to assess the Apo B100/A1 ratio as a marker of cardiovascular risk in children with epilepsy aged 5–14 years on long-term anti-seizure medication monotherapy with either sodium valproate, oxcarbazepine, or levetiracetam. Apo B100/A1 ratio showed an increase after six months of monotherapy with oxcarbazepine (P=0.05).

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Authors and Affiliations

  1. Department of Biochemistry, Pt B D Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India

    Seema Lekhwani

  2. Department of Biochemistry, NC Medical College, Israna, Panipat, Haryana, India

    Anjali Dhama

  3. Department of Pediatrics, All India Institute of Medical Sciences, Guwahati, Assam, India

    Jaya Shankar Kaushik

Authors
  1. Seema Lekhwani
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  2. Anjali Dhama
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  3. Jaya Shankar Kaushik
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Contributions

SL, JSK: Concept and design of the study; AD: Data collection under the supervision of SL, JSK; JSK, SL, AD: drafting the manuscript and review of literature; JSK,SL: Critical review of the manuscript for intellectual content. All authors have approved the final version.

Corresponding author

Correspondence to Anjali Dhama.

Ethics declarations

IEC, Pt. BD Sharma PGIMS; No. BREC/Th/19/Bio/02, dated Dec 26, 2019.

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None stated.

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Additional material related to this study is available with the online version at www.indianpediatrics.net

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Lekhwani, S., Dhama, A. & Kaushik, J.S. Change in Apo B100/A1 Ratio in Children With Epilepsy on Monotherapy With Sodium Valproate, Oxcarbazepine or Levetiracetam. Indian Pediatr 60, 492–494 (2023). https://doi.org/10.1007/s13312-023-2916-z

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  • DOI: https://doi.org/10.1007/s13312-023-2916-z

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