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Six-Year Surveillance of Acquired Bloodstream Infection in a Pediatric Intensive Care Unit in Israel

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Abstract

Objectives

We studied the profile of bloodstream infections (BSI) in the pediatric intensive care unit (PICU) and identified predictors of mortality.

Methods

The study collected data from hospital records for children younger than 18-years who developed BSI during their PICU stay between 2014 and 2019.

Results

In 114 patients, 136 PICU-acquired BSIs with 152 pathogens were documented. The incidence of BSI was 47.12/1000 PICU admissions and 7.95/1000 PICU hospital days. Gram-negative rods accounted for 75% of isolates, Gram-positive cocci accounted for 21.7% of isolates, and fungi accounted for 3.3% of isolated pathogens. ICU mortality was observed in 25 (21.9%) patients with a BSI compared to 94 (3.1%) patients without a BSI (P<0.001). Hemodynamic instability (P=0.014, OR 4.10, 95%CI 1.33–12.66), higher blood urea nitrogen (BUN) (P=0.044), and lower albumin levels (P=0.029) were associated with increased risk of ICU mortality.

Conclusion

BSI in the PICU is associated with increased mortality. Early identification and management of risk factors independently associated with poor clinical outcomes in these patients should be aimed to ensure improved survival.

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Funding

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Author notes

  1. These authors contributed equally to the article.

Authors and Affiliations

  1. Pediatric Infectious Diseases Unit, Rambam Health Care Campus, Haifa, 31096, Israel

    Halima Dabaja-Younis, Ranaa Damouni Shalabi, Tamar Alon, Yael Shachor-Meyouhas & Imad Kassis

  2. Infection Prevention and Control Unit, Rambam Health Care Campus, Haifa, Israel

    Halima Dabaja-Younis, Tamar Alon & Khetam Hussein

  3. Pediatric Intensive Care Unit, Rambam Health Care Campus, Haifa, Israel

    Josef Ben-Ari & Amir Hadash

  4. The Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

    Halima Dabaja-Younis, Maha Alaiyan, Josef Ben-Ari, Amir Hadash, Yael Shachor-Meyouhas, Imad Kassis & Khetam Hussein

Authors
  1. Halima Dabaja-Younis
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  2. Maha Alaiyan
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  3. Ranaa Damouni Shalabi
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  4. Josef Ben-Ari
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  5. Tamar Alon
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  6. Amir Hadash
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  7. Yael Shachor-Meyouhas
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  8. Imad Kassis
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  9. Khetam Hussein
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Contributions

HDY,IK,KH: designed the study, analyzed the data and edited the manuscript; MA,RDS: gathered the data and reviewed the manuscript; JBA,AH, YSM,TA: helped in gathering the data and revising the manuscript. All authors approved the final version of manuscript, and are accountable for all aspects related to the study.

Corresponding author

Correspondence to Halima Dabaja-Younis.

Ethics declarations

Local Ethics Committee; No.0053-19-RMB, dated Jan 24, 2019.

Additional information

Competing interests

None stated.

Note

Additional material related to this study is available with the online version at www.indianpediatrics.net

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Cite this article

Dabaja-Younis, H., Alaiyan, M., Shalabi, R.D. et al. Six-Year Surveillance of Acquired Bloodstream Infection in a Pediatric Intensive Care Unit in Israel. Indian Pediatr 60, 41–44 (2023). https://doi.org/10.1007/s13312-023-2693-8

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  • DOI: https://doi.org/10.1007/s13312-023-2693-8

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