Abstract
Background
Impulse oscillometry is an effort-independent technique of assessment of airway resistance and reactance, and can be performed in children unable to complete spirometry.
Objective
To evaluate the utility of impulse oscillometry and spirometry for assessing asthma control in children.
Study design
Prospective cohort study.
Participants
Children aged 5–15 years, with mild to severe persistent asthma.
Intervention
On each 3-monthly follow-up visit, clinical assessment, classification of control of asthma, impulse oscillometry and spirometry were performed.
Outcome
Utility of impulse oscillometry parameters [impedance (Z5), resistance (R5), reactance (X5) at 5 Hz, and R5-20 (resistance at 20Hz -5Hz) (% predicted), and area of reactance (AX, actual values)] and FEV1 (% predicted) to discriminate between controlled and uncontrolled asthma was assessed by receiver operating characteristic (ROC) curve. Association of FEV1 and impulse oscillometry parameters over time with controlled asthma was evaluated by generalized estimating equation model.
Results
Number of visits in 256 children [mean (SD) age, 100 (41.6) mo; boys: 198 (77.3%)], where both impulse oscillometry and spirometry were performed was 2616; symptoms were controlled in 48.9% visits. Area under the curve for discrimination between controlled and uncontrolled asthma by FEV1, AX, R5-20, Z5, R5, and X5 were 0.58, 0.55, 0.55, 0.52, 0.52 and 0.52, respectively. FEV1 [OR (95% CI): 1.02 (1.01–1.03)] and AX [OR (95% CI): 0.88 (0.81–0.97)] measured over the duration of follow-up were significantly associated with controlled asthma.
Conclusion
Spirometry and impulse oscillometry parameters are comparable in ascertaining controlled asthma. Impulse oscillometry being less effort-dependent may be performed for monitoring control of childhood asthma, especially in younger children.
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CSIR-IGIB
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LD: conduct of study, literature search and preparation of manuscript; AM: literature search, data analysis and preparation of manuscript; TS: study design, data analysis and review of manuscript; AA: study design and review of manuscript; SKK: study design and review of manuscript; RL: study design and review of manuscript.
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Dawman, L., Mukherjee, A., Sethi, T. et al. Role of Impulse Oscillometry in Assessing Asthma Control in Children. Indian Pediatr 57, 119–123 (2020). https://doi.org/10.1007/s13312-020-1727-8
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DOI: https://doi.org/10.1007/s13312-020-1727-8