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Hemophagocytic lymphohistiocytosis in a young child

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Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a multisystem disorder mediated by cytokine storm and is characterized by fever, pancytopenia and organomegaly coupled with laboratory features like hyperferritinemia, hypertriglyceridemia, hypofibrinogenemia and transaminitis. Etiology can be genetic or acquired such as infections, malignancy and autoimmune disorders. Diagnosis, identification of underlying etiology and management of HLH remain tough clinical puzzles to sort out for the managing physician. We report a clinicopathological conference of a three-year-old boy who had such a presentation and succumbed during the hospital stay.

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Authors and Affiliations

  1. Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Anju Gupta, Pandiarajan Vignesh & Deepti Suri

  2. Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Uma Nahar Saikia

  3. Department of Virology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Mini P. Singh

Authors
  1. Uma Nahar Saikia
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  2. Anju Gupta
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  3. Pandiarajan Vignesh
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  4. Deepti Suri
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  5. Mini P. Singh
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Correspondence to Anju Gupta.

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Saikia, U.N., Gupta, A., Vignesh, P. et al. Hemophagocytic lymphohistiocytosis in a young child. Indian Pediatr 53, 505–511 (2016). https://doi.org/10.1007/s13312-016-0880-6

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  • DOI: https://doi.org/10.1007/s13312-016-0880-6

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