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Effect of simultaneous administration of oral polio vaccine on local reaction of BCG vaccine in term infants

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Abstract

Objective

To study local reaction and to ascertain timing of scar formation in infants after BCG vaccination at birth, with and without simultaneous administration of trivalent OPV.

Design

Prospective observational study.

Setting

Teaching hospital in Lucknow, India.

Participants

152 term neonates born in the hospital and given BCG and OPV 0-dose simultaneously before discharge, within 7 days of birth (Group I), and 122 infants born at home or in private health facility, not given OPV-0 dose, coming for vaccination within 7 days of age (Group 2).

Intervention/Observation

Follow up done at 6 week, 10 week, 14 week and 9 months. Local reaction was recorded at the site of BCG vaccination.

Results

Scar formed in ≤14 wks in 51.3% and 89.3% babies in Group 1 and Group 2, respectively following BCG vaccination (P<0.001). At 9 months, scar developed in 93.9% infants in Group I and 94.3% babies in Group II. Abortive reaction and non-reactors were similar in both groups (P>0.05).

Conclusions

Simultaneous administration of BCG vaccine with trivalent OPV to term infants in early neonatal period prolongs the time of scar formation but sequence of local reaction is not affected.

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References

  1. Yewale V, Choudhary P, Thackar N, editors. IAP Guide Book on Immunization. IAP Committee on Immunization 2009–2011. p. 47–52.

  2. Faridi MMA, Krishnamurthy S. Abortive reaction and time of scar formation after BCG vaccination. Vaccine. 2008;17:26:289–90.

    Article  Google Scholar 

  3. Kaur S, Faridi MMA, Agarwal KN. BCG vaccination reaction in low birth weight infants. Indian J Med Res. 2002;116:64–9.

    CAS  PubMed  Google Scholar 

  4. Sartono E, Lisse IM, Terveer EM, Van de Sande PJM, Whittle H, Fisker AB, et al. Oral polio vaccine influences the immune response to BCG vaccination. PLoS One. 2010;5: e10328.

    Article  PubMed Central  PubMed  Google Scholar 

  5. Lubchenco LO, Hansman C, Dressler M, Boyd E. Intrauterine growth as estimated from live born birth weight data at 24 to 42 weeks of gestation. Pediatrics. 1963;32:793–800.

    CAS  PubMed  Google Scholar 

  6. Infant and Young Child Feeding Counseling: A Training Course: The 3 in 1 course-2008 Version (An Integrated Course on Breastfeeding, Complementary feeding and Infant Feeding & HIV — Counseling). Breastfeeding Promotion Network of India and IBFAN Asia.

  7. Seth V, Kabra SK. BCG Vaccination. In: Essentials of Tuberculosis in Children, 3rd Ed; 2006; p. 597–620.

    Chapter  Google Scholar 

  8. Thayyil-sudan S, Kumar A, Singh M, Paul VK, Deorari AK. Safety and efficacy of BCG vaccination in preterm babies. Arch Dis Child. 1999;81:F–646.

    Google Scholar 

  9. Gupta P, Faridi MMA, Shah D, Dev G. BCG reaction in twin newborns: Effect of zygosity and chorionicity. Indian Pediatr. 2008;45:271–7.

    PubMed  Google Scholar 

  10. Ahmad S, Javid I. Absence of scar formation in infants after BCG vaccination. Professional Med J. 2006;13:637–41.

    Google Scholar 

  11. Lakhar BB. Neonatal BCG vaccination and scar success. Indian Pediatr. 1995; 32:1323.

    Google Scholar 

  12. Joshi S. BCG vaccination (immunization dialogue). Indian Pediatr. 2000;37:332–3.

    CAS  PubMed  Google Scholar 

  13. Sedaghatian M, Hashaem F, Hossain MM. Bacillus Calmette-Guerin vaccination in preterm infants. Int J Tuber Lung Dis. 1998;2:679–82.

    CAS  Google Scholar 

  14. Fine PEM, Ponnighaus JM, Maine N. The distribution and implication of BCG scar in Northern Malawi. Bull World Health Organ. 1989;67:35–42.

    PubMed Central  CAS  PubMed  Google Scholar 

  15. Jensen KJ, Karkov HS, Lund N, Andersen A, Eriksen HB, Barbosa AG, et al. The immunological effects of oral polio vaccine provided with BCG vaccine at birth: A randomised trial. Vaccine. 2014;32:5949–56.

    Article  CAS  PubMed  Google Scholar 

  16. Sallusto F, Lenig D, Förster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999;401:708–12.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, Era’s Lucknow Medical College, Lucknow, UP, India

    M. M. A. Faridi & Shitanshu Srivastava

  2. E-9 GTB Hospital, Delhi, 110 095, India

    M. M. A. Faridi

Authors
  1. M. M. A. Faridi
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  2. Shitanshu Srivastava
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Corresponding author

Correspondence to M. M. A. Faridi.

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Faridi, M.M.A., Srivastava, S. Effect of simultaneous administration of oral polio vaccine on local reaction of BCG vaccine in term infants. Indian Pediatr 52, 115–118 (2015). https://doi.org/10.1007/s13312-015-0583-4

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  • DOI: https://doi.org/10.1007/s13312-015-0583-4

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