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Caspases: Therapeutic Targets in Neurologic Disease

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Neurotherapeutics

Abstract

Specific therapies for neurologic diseases such as Alzheimer’s disease provide the potential for better clinical outcomes. Expression of caspases in the brain is developmentally regulated, and dysregulated in neurologic disease, supporting that caspases may be therapeutic targets. The activity of caspases is carefully regulated via binding partners, cleavage, or endogenous inhibitors to prevent spontaneous activation, which could lead to aberrant cell death. This review serves as a brief examination of the current understanding of the regulation and function of caspases, and approaches to specifically target aberrant caspase activity. The use of proper tools to investigate individual caspases is addressed. Moreover, it summarizes the reports of various caspases in Alzheimer’s disease studies. A better understanding of specific caspase pathways in heath and neurodegenerative disease is crucial for identifying specific targets for the development of therapeutic interventions.

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Acknowledgments

Carol M. Troy was supported in part by National Institutes of Health grant RO1NS081333.

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Authors and Affiliations

  1. Department of Pathology and Cell Biology, Columbia University Medical Center, 650 W. 168th Street, New York, NY, 10032, USA

    Carol M. Troy & Ying Y. Jean

  2. Department of Neurology, Columbia University Medical Center, 650 W. 168th Street, New York, NY, 10032, USA

    Carol M. Troy

  3. The Taub Institute for the Study of Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, 650 W. 168th Street, New York, NY, 10032, USA

    Carol M. Troy

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Correspondence to Carol M. Troy.

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Troy, C.M., Jean, Y.Y. Caspases: Therapeutic Targets in Neurologic Disease. Neurotherapeutics 12, 42–48 (2015). https://doi.org/10.1007/s13311-014-0307-9

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