Abstract
Purpose
The current pooling up analysis aimed to evaluate whether aortic calcification (AC) was a potential risk factor for anastomotic leakage (AL) after colorectal surgery.
Methods
In this study, we searched studies in three databases including PubMed, Embase, and the Cochrane Library on April 20, 2022. In order to investigate the association between AC and AL, the hazard ratios (HRs) and 95% confidence intervals (CIs) of AC were pooled up. Our study was performed with RevMan 5.3 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.
Results
We finally enrolled eight studies involving 1955 patients for statistical analysis. As for all patients, we found that AC could significantly increase the risk of AL after surgery (HR = 2.31, I2 = 0%, 95%CI = 1.58 to 3.38, P < 0.01). In five studies including patients undergoing colorectal surgery (benign diseases and cancers), AC was also a risk factor for AL (HR = 3.30, I2 = 2%; 95%CI = 1.83 to 5.95, P < 0.01). In terms of the other three studies that only included CRC patients, there was still a correction between AC and AL (HR = 1.80, I2 = 0%, 95%CI = 1.10 to 2.96, P = 0.02).
Conclusion
Patients with AC were more likely to develop AL after colorectal surgery. Moreover, subgroup analysis suggested that AC was a predictor for AL after CRC surgery.
Similar content being viewed by others
Data availability
The data was accessed in the database.
References
Rutkow IM (2000) Colorectal surgery. Arch Surg 135(1):97. https://doi.org/10.1001/archsurg.135.1.97
Parker JM, Feldmann TF, Cologne KG (2017) Advances in laparoscopic colorectal surgery. Surg Clin North Am 97(3):547–560. https://doi.org/10.1016/j.suc.2017.01.005
Labianca R, Nordlinger B, Beretta GD, Mosconi S, Mandalà M, Cervantes A, Arnold D, ESMO Guidelines Working Group (2013) Early colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of oncology: Off J Euro Soc Med Oncol 24:64–72. https://doi.org/10.1093/annonc/mdt354
Rawla P, Sunkara T, Barsouk A (2019) Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Przeglad gastroenterologiczny 14(2):89–103. https://doi.org/10.5114/pg.2018.81072
Peng D, Cheng YX, Cheng Y (2021) Improved overall survival of colorectal cancer under multidisciplinary team: a meta-analysis. Biomed Res Int 2021:5541613. https://doi.org/10.1155/2021/5541613
Ba L, Wang Q, Wang H, Zhu L, Zhang T, Ren J, Lin Z (2021) Survival analysis and prognostic factors of palliative radiotherapy in patients with metastatic colorectal cancer: a propensity score analysis. J Gastrointest Oncol 12(5):2211–2222. https://doi.org/10.21037/jgo-21-540
Janani B, Vijayakumar M, Priya K, Kim JH, Prabakaran DS, Shahid M, Al-Ghamdi S, Alsaidan M, Othman Bahakim N, Hassan Abdelzaher M, Ramesh T (2022) EGFR-based targeted therapy for colorectal cancer-promises and challenges. Vaccines 10(4):499. https://doi.org/10.3390/vaccines10040499
Liu XY, Yuan C, Kang B, Cheng YX, Tao W, Zhang B, Wei ZQ, Peng D (2022) Predictors associated with planned and unplanned admission to intensive care units after colorectal cancer surgery: a retrospective study. Supp Care Cancer 30(6):5099–5105. https://doi.org/10.1007/s00520-022-06939-1
Cheng YX, Tao W, Liu XY, Yuan C, Zhang B, Wei ZQ, Peng D (2022) Hypertension remission after colorectal cancer surgery: a single-center retrospective study. Nutr Cancer 74(8):2789–2795. https://doi.org/10.1080/01635581.2021.2025256
Peng D, Liu XY, Cheng YX, Tao W, Cheng Y (2021) Improvement of diabetes mellitus after colorectal cancer surgery: a retrospective study of predictive factors for type 2 diabetes mellitus remission and overall survival. Front Oncol 11:694997. https://doi.org/10.3389/fonc.2021.694997
Kawada K, Hasegawa S, Hida K, Hirai K, Okoshi K, Nomura A, Kawamura J, Nagayama S, Sakai Y (2014) Risk factors for anastomotic leakage after laparoscopic low anterior resection with DST anastomosis. Surg Endosc 28(10):2988–2995. https://doi.org/10.1007/s00464-014-3564-0
Kingham TP, Pachter HL (2009) Colonic anastomotic leak: risk factors, diagnosis, and treatment. J Am Coll Surg 208(2):269–278. https://doi.org/10.1016/j.jamcollsurg.2008.10.015
McDermott FD, Heeney A, Kelly ME, Steele RJ, Carlson GL, Winter DC (2015) Systematic review of preoperative, intraoperative and postoperative risk factors for colorectal anastomotic leaks. Br J Surg 102(5):462–479. https://doi.org/10.1002/bjs.9697
Cheng YX, Tao W, Liu XY, Zhang H, Yuan C, Zhang B, Zhang W, Peng D (2022) does chronic kidney disease affect the surgical outcome and prognosis of patients with gastric cancer? Meta-Anal Nutrit cancer 74(6):2059–2066. https://doi.org/10.1080/01635581.2021.1993277
Yamamoto S, Fujita S, Akasu T, Inada R, Moriya Y, Yamamoto S (2012) Risk factors for anastomotic leakage after laparoscopic surgery for rectal cancer using a stapling technique. Surg Laparos endos Percut Techn 22(3):239–243. https://doi.org/10.1097/SLE.0b013e31824fbb56
Silva-Velazco J, Stocchi L, Costedio M, Gorgun E, Kessler H, Remzi FH (2016) Is there anything we can modify among factors associated with morbidity following elective laparoscopic sigmoidectomy for diverticulitis? Surg Endosc 30(8):3541–3551. https://doi.org/10.1007/s00464-015-4651-6
Zhu QL, Feng B, Lu AG, Wang ML, Hu WG, Li JW, Mao ZH, Zheng MH (2010) Laparoscopic low anterior resection for rectal carcinoma: complications and management in 132 consecutive patients. World J Gastroenterol 16(36):4605–4610. https://doi.org/10.3748/wjg.v16.i36.4605
Kayano H, Okuda J, Tanaka K, Kondo K, Tanigawa N (2011) Evaluation of the learning curve in laparoscopic low anterior resection for rectal cancer. Surg Endosc 25(9):2972–2979. https://doi.org/10.1007/s00464-011-1655-8
Rifkin RD, Parisi AF, Folland E (1979) Coronary calcification in the diagnosis of coronary artery disease. Am J Cardiol 44(1):141–147. https://doi.org/10.1016/0002-9149(79)90263-7
Tao W, Cheng YX, Zou YY, Peng D, Zhang W (2021) Aorta calcification increases the risk of anastomotic leakage after gastrectomy in gastric cancer patients. Cancer Manag Res 13:3857–3865. https://doi.org/10.2147/CMAR.S306942
Lee SL, Jeon CH, Park KB, Seo HS, Lee HH (2022) Association between vascular calcification and esophagojejunal anastomotic complications after total gastrectomy for gastric cancer: a propensity-matched study. Cur Oncol. 29(5):3224–3231. https://doi.org/10.3390/curroncol29050262
Goense L, van Rossum PSN, Weijs TJ, van Det MJ, Nieuwenhuijzen GA, Luyer MD, van Leeuwen MS, van Hillegersberg R, Ruurda JP, Kouwenhoven EA (2016) Aortic calcification increases the risk of anastomotic leakage after ivor-lewis esophagectomy. Ann Thorac Surg 102(1):247–252. https://doi.org/10.1016/j.athoracsur.2016.01.093
Tzortzakakis A, Kalarakis G, Huang B, Terezaki E, Koltsakis E, Kechagias A, Tsekrekos A, Rouvelas I (2022) Role of radiology in the preoperative detection of arterial calcification and celiac trunk stenosis and its association with anastomotic leakage post esophagectomy, an up-to-date review of the literature. Cancers 14(4):1016. https://doi.org/10.3390/cancers14041016
Pochhammer J, Tröster F, Blumenstock G, Closset J, Lang S, Weller MP, Schäffer M (2018) Calcification of the iliac arteries: a marker for leakage risk in rectal anastomosis-a blinded clinical trial. Int J Colorectal Dis 33(2):163–170. https://doi.org/10.1007/s00384-017-2949-7
Deguelte S, Besson R, Job L, Hoeffel C, Jolly D, Kianmanesh R (2021) Assessing abdominal aortic calcifications before performing colocolic or colorectal anastomoses: a case-control study. J Res Med Sci 26:110. https://doi.org/10.4103/jrms.JRMS_874_19
Boersema GS, Vakalopoulos KA, Kock MC, van Ooijen PM, Havenga K, Kleinrensink GJ, Jeekel J, Lange JF (2016) Is aortoiliac calcification linked to colorectal anastomotic leakage? A case-control study. Int J Surg 25:123–127. https://doi.org/10.1016/j.ijsu.2015.12.008
Eveno C, Latrasse V, Gayat É, Lo Dico R, Dohan A, Pocard M (2016) Colorectal anastomotic leakage can be predicted by abdominal aortic calcification on preoperative CT scans: A pilot study. J Visc Surg 153(4):253–257. https://doi.org/10.1016/j.jviscsurg.2016.03.007
Komen N, Klitsie P, Dijk JW, Slieker J, Hermans J, Havenga K, Oudkerk M, Weyler J, Kleinrensink GJ, Lange JF (2011) Calcium score: a new risk factor for colorectal anastomotic leakage. Am J Surg 201(6):759–765. https://doi.org/10.1016/j.amjsurg.2010.01.033
Knight KA, Fei CH, Boland KF, Dolan DR, Golder AM, McMillan DC, Horgan PG, Black DH, Park JH, Roxburgh CSD (2021) Aortic calcification is associated with non-infective rather than infective postoperative complications following colorectal cancer resection: an observational cohort study. Eur Radiol 31(6):4319–4329. https://doi.org/10.1007/s00330-020-07189-7
Lee SY, Yeom SS, Kim CH, Kim YJ, Kim HR (2020) A new aortoiliac calcification scoring system to predict grade C anastomotic leak following rectal cancer surgery. Tech Coloproctol 24(8):843–849. https://doi.org/10.1007/s10151-020-02246-1
Morita S, Tsuruta M, Okabayashi K, Shigeta K, Seishima R, Monno M, Itano O, Kitagawa Y (2022) Evaluation of abdominal aortic calcification by plain CT predicts anastomotic leakage in laparoscopic surgery for colorectal cancer. Jpn J Clin Oncol 52(2):122–127. https://doi.org/10.1093/jjco/hyab196
Hoek VT, Edomskis PP, Menon AG, Kleinrensink GJ, Lagarde SM, Lange JF, Wijnhoven BPL (2020) Arterial calcification is a risk factor for anastomotic leakage after esophagectomy: a systematic review and meta-analysis. Euro J Surg Oncol 46(11):1975–1988. https://doi.org/10.1016/j.ejso.2020.06.019
Tong L, Xie D, Song X, Wu X, Wen S, Liu A (2020) Is abdominal vascular calcification score valuable in predicting the occurrence of colorectal anastomotic leakage? A meta-analysis. Int J Colorectal Dis 35(4):641–653. https://doi.org/10.1007/s00384-020-03513-1
Hoek VT, Edomskis PP, Menon AG, Dwarkasing RS, Kleinrensink GJ, Jeekel J, Lange JF (2021) Calcification of the aorta-iliac trajectory as a risk factor for anastomotic leakage in colorectal surgery: individual patient data meta-analysis and systematic review. Surg Technol Int 39:155–165. https://doi.org/10.52198/21.STI.39.CR1479
Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6(7):e1000097. https://doi.org/10.1371/journal.pmed.1000097
Stang A (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25(9):603–605. https://doi.org/10.1007/s10654-010-9491-z
Szulc P (2016) Abdominal aortic calcification: a reappraisal of epidemiological and pathophysiological data. Bone 84:25–37. https://doi.org/10.1016/j.bone.2015.12.004
Bastos Gonçalves F, Voûte MT, Hoeks SE, Chonchol MB, Boersma EE, Stolker RJ, Verhagen HJ (2012) Calcification of the abdominal aorta as an independent predictor of cardiovascular events: a meta-analysis. Heart 98(13):988–994. https://doi.org/10.1136/heartjnl-2011-301464
Harbaugh CM, Terjimanian MN, Lee JS, Alawieh AZ, Kowalsky DB, Tishberg LM, Krell RW, Holcombe SA, Wang SC, Campbell DA Jr, Englesbe MJ (2013) Abdominal aortic calcification and surgical outcomes in patients with no known cardiovascular risk factors. Ann Surg 257(4):774–781. https://doi.org/10.1097/SLA.0b013e31826ddd5f
Ichii M, Ishimura E, Shima H, Ohno Y, Ochi A, Nakatani S, Tsuda A, Ehara S, Mori K, Fukumoto S, Naganuma T, Takemoto Y, Nakatani T, Inaba M (2013) Quantitative analysis of abdominal aortic calcification in CKD patients without dialysis therapy by use of the Agatston score. Kidney Blood Press Res 38(2–3):196–204. https://doi.org/10.1159/000355768
Beard JR, Officer A, de Carvalho IA, Sadana R, Pot AM, Michel JP, Lloyd-Sherlock P, Epping-Jordan JE, Peeters GMEEG, Mahanani WR, Thiyagarajan JA, Chatterji S (2016) The world report on ageing and health: a policy framework for healthy ageing. Lancet 387(10033):2145–2154. https://doi.org/10.1016/S0140-6736(15)00516-4
Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F (2017) Global patterns and trends in colorectal cancer incidence and mortality. Gut 66(4):683–691. https://doi.org/10.1136/gutjnl-2015-310912
Vignali A, Gianotti L, Braga M, Radaelli G, Malvezzi L, Di Carlo V (2000) Altered microperfusion at the rectal stump is predictive for rectal anastomotic leak. Dis Colon Rectum 43(1):76–82. https://doi.org/10.1007/BF02237248
Braunschmid T, Hartig N, Baumann L, Dauser B, Herbst F (2017) Influence of multiple stapler firings used for rectal division on colorectal anastomotic leak rate. Surg Endosc 31(12):5318–5326. https://doi.org/10.1007/s00464-017-5611-0
Chung RS (1987) Blood flow in colonic anastomoses. Eff Stapl Sut Ann Surg. 206(3):335–339. https://doi.org/10.1097/00000658-198709000-00011
Watanabe J, Ota M, Suwa Y, Suzuki S, Suwa H, Momiyama M, Ishibe A, Watanabe K, Masui H, Nagahori K, Ichikawa Y, Endo I (2015) Evaluation of the intestinal blood flow near the rectosigmoid junction using the indocyanine green fluorescence method in a colorectal cancer surgery. Int J Colorectal Dis 30(3):329–335. https://doi.org/10.1007/s00384-015-2129-6
Acknowledgements
We acknowledgment to all the authors in this article.
Funding
This study is supported by CQMU Program for Youth Innovation in Future Medicine (W0190).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that there are no conflicts of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Liu, XR., Liu, F., Zhang, W. et al. The aortic calcification is a risk factor for colorectal anastomotic leakage. Updates Surg 75, 1857–1865 (2023). https://doi.org/10.1007/s13304-023-01630-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13304-023-01630-4