Abstract
To evaluate the short- and long-term survival of hyperthermic intraperitoneal chemotherapy (HIPEC) in the patients with advanced gastric cancer (AGC) through randomized controlled trials (RCTs). We analyzed the endpoints of AGC patients including 1-, 2-, 3-, and 5-year overall survival (OS), intestinal anastomotic leakage, myelosuppression, nausea and vomiting from included studies. And we retrieved RCTs from medical literature databases. Risk ratios (RR) was used to calculated the endpoints. Totally, we retrieved 13 articles (14 trial comparisons) which contained 1091 patients. They were randomized to HIPEC group and control group. The results showed that there was no significant differences in survival rates between HIPEC group and control group at 1-, 2- and 3-year follow-up, while a statistical significant overall survival effect was found at the 5-year follow-up [RR: 1.20, 95% CI 1.01 to 1.43, I2 = 0.0%]. And there is no significant difference in the risk of intestinal anastomotic leakage, myelosuppression and nausea and vomiting. Compared with the control group, HIPEC could improve the long-term OS without increasing the risk of adverse effect in AGC patients with/without peritoneal carcinomatosis, but there was no benefit at short-term OS.
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13304_2022_1376_MOESM1_ESM.tif
Supplementary file1 Forest plot of the risk of intestinal anastomotic leakage in HIPEC group and the Control group. HIPEC hyperthermic intraperitoneal chemotherapy (TIF 1446 KB)
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Supplementary file2 Forest plot of the risk of myelosuppression in HIPEC group and the Control group. HIPEC hyperthermic intraperitoneal chemotherapy (TIF 1462 KB)
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Supplementary file3 Forest plot of the risk of nausea and vomiting in HIPEC group and the Control group. HIPEC hyperthermic intraperitoneal chemotherapy (TIF 1512 KB)
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Supplementary file4 Funnel plot of OS at 1 year follow-up. RR= Risk Ratio, HIPEC hyperthermic intraperitoneal chemotherapy, OS overall survival (TIF 475 KB)
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Supplementary file5 Funnel plot of OS at 3 years follow-up. RR Risk Ratio, HIPEC hyperthermic intraperitoneal chemotherapy, OS overall survival (TIF 475 KB)
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Supplementary file6 Sensitivity analysis of OS at 1 year follow-up. HIPEC hyperthermic intraperitoneal chemotherapy, OS overall survival (TIF 442 KB)
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Supplementary file7 Sensitivity analysis of OS at 2 years follow-up. HIPEC hyperthermic intraperitoneal chemotherapy, OS overall survival(TIF 442 KB)
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Supplementary file8 Sensitivity analysis of OS at 3 years follow-up. HIPEC hyperthermic intraperitoneal chemotherapy, OS overall survival (TIF 442 KB)
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Deng, H., Li, B. & Qin, X. The short- and long-term survival of hyperthermic intraperitoneal chemotherapy (HIPEC) in the advanced gastric cancer with/without peritoneal carcinomatosis: a systematic review and meta-analysis of randomized controlled trials. Updates Surg 74, 1805–1816 (2022). https://doi.org/10.1007/s13304-022-01376-5
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DOI: https://doi.org/10.1007/s13304-022-01376-5