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Hemocoagulative post-operative changes after laparoscopic surgery compared to open surgery: the role of lupus anticoagulant

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Abstract

Although still debated, post-operative modification of hemostasis seems to be less pronounced after laparoscopy compared to open surgery. Antiphospholipid antibodies might play a role in the post-operative thromboembolic risk, although their evaluation in surgical patients has never been performed. Post-operative modification of antiphospholipid antibodies could be related to the surgical approach (laparoscopic or open). In this prospective study, the authors statistically compared the pre-operative values and post-operative modification of antiphospholipid antibodies in two homogeneous groups of patients operated on by laparoscopic and open surgery. No statistical differences within each group and between the two groups were shown comparing mean values of pre-operative and post-operative antiphospholipid antibodies. In the open group, there was a significant difference between pre-operative and post-operative LAC means (P < 0.01). In the laparoscopic group, on the contrary, no significant change in LAC values between pre- and post-operative tests (P = 0.55) was observed. Since LAC could be related to coagulation disorders, this study seems to support that laparoscopic surgery might induce a less risk of post-operative thromboembolic disease.

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Funding

Supported by a grant from the University of Catania, Italy (FIR 2014).

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Authors and Affiliations

  1. Department of Surgery, University of Catania, Catania, Italy

    Rosario Vecchio, Salvatore Marchese, Eva Intagliata & Francesco Basile

  2. Department of Medical Sciences, Surgical Sciences and Advanced Technologies, Hemostasis Unit, University of Catania, Catania, Italy

    Emma Cacciola

  3. Hematologic Unit, Department of Biomedical Science, University of Catania, Catania, Italy

    Rossella Rosaria Cacciola

  4. Department of Clinic and Specialist Medicine, University of Palermo, Palermo, Italy

    Graziano Troina

Authors
  1. Rosario Vecchio
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  2. Emma Cacciola
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  3. Rossella Rosaria Cacciola
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  4. Salvatore Marchese
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  5. Graziano Troina
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  6. Eva Intagliata
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  7. Francesco Basile
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Correspondence to Eva Intagliata.

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Vecchio, R., Cacciola, E., Cacciola, R.R. et al. Hemocoagulative post-operative changes after laparoscopic surgery compared to open surgery: the role of lupus anticoagulant. Updates Surg 72, 1223–1227 (2020). https://doi.org/10.1007/s13304-020-00724-7

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  • DOI: https://doi.org/10.1007/s13304-020-00724-7

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