Skip to main content

Advertisement

Log in

Volume and outcomes after esophageal cancer surgery: the experience of the Region of Lombardy—Italy

  • Original Article
  • Published:
Updates in Surgery Aims and scope Submit manuscript

Abstract

Surgical procedures for cancer of the esophagus are complex operations, with considerable perioperative morbidity and mortality that require high use of resources. Recent reports indicate better results with centralization of these procedures, referring patients to high-volume dedicated hospitals. The aim of this study was to analyze the results of resective surgery for cancer of the esophagus and cardia performed in hospitals of the Region of Lombardy over the period 2005–2011, in terms of volume of operations, 30-day postoperative mortality, and length of hospitalization. The results showed a significant relation between reduction of mortality rate and number of resections performed in intermediate- and high-volume centers. In the Region of Lombardy there is an inverse relation between volume of esophagectomies in the single hospital, length of postoperative hospital stay, and postoperative 30-day mortality. Centralization of care on a regional level and standardized clinical pathways of diagnosis and care at single healthcare organizations and professionals should be implemented to improve clinical results in patients affected by esophageal and cardia cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Sant M, Allemani C, Santaquilani M, Knijn A, Marchesi F, Capocaccia R, EUROCARE Working Group. EUROCARE-4 (2009) Survival of cancer patients diagnosed in 1995–1999. Results and commentary. Eur J Cancer 45:931–991

    Article  PubMed  Google Scholar 

  2. Jamieson GG, Mathew G, Ludemann R, Wayman J, Myers JC, Devitt PG (2004) Postoperative mortality following oesophagectomy and problems in reporting its rate. Br J Surg 91:943–947

    Article  PubMed  CAS  Google Scholar 

  3. Birkmeyer JD, Siewers AE, Finlayson EV, Stukel TA, Lucas FL, Batista I, Welch HG, Wennberg DE (2002) Hospital volume and surgical mortality in the United States. N Engl J Med 346:1128–1137

    Article  PubMed  Google Scholar 

  4. Birkmeyer JD, Stukel TA, Siewers AE, Goodney PP, Wennberg DE, Lucas FL (2003) Surgeon volume and operative mortality in the United States. N Engl J Med 349:2117–2127

    Article  PubMed  CAS  Google Scholar 

  5. Anderson O, Ni Z, Møller H, Coupland VH, Davies EA, Allum WH, Hanna GB (2011) Hospital volume and survival in oesophagectomy and gastrectomy for cancer. Eur J Cancer 47:2408–2414

    Article  PubMed  Google Scholar 

  6. NHS Executive Guidance on Commissioning Cancer Services (2001) Improving Outcomes in Upper Gastrointestinal Cancers, the Manual. Department of Health, London

    Google Scholar 

  7. Palser TR, Cromwell DA, Hardwick RH, Riley SA, Greenaway K, Allum W, van der Meulen JH (2009) Re-organisation of oesophago-gastric cancer care in England: progress, remaining challenges. BMC Health Serv Res 9:204. doi:10.1186/1472-6963-9-204

    Article  PubMed  Google Scholar 

  8. http://www.salute.gov.it/programmazioneSanitariaELea/paginaInternaProgrammazioneSanitariaELea.jsp?menu=piano&id=2905&lingua=italiano

  9. Charlson M, Szatrowski TP, Peterson J, Gold J (1994) Validation of a combined comorbidity index. J Clin Epidemiol 47(11):1245–1251

    Article  PubMed  CAS  Google Scholar 

  10. Luft HS, Bunker JP, Enthoven AC (1979) Should operations be regionalized? The empirical relation between surgical volume and mortality. N Engl J Med 301(25):1364–1369

    Article  PubMed  CAS  Google Scholar 

  11. Dikken JL, Dassen AE, Lemmens VEP, Putter H, Krijnen P, van der Geest L, Bosscha K, Verheij M, van de Velde CJ, Wouters MW (2012) Effect of hospital volume on postoperative mortality and survival after oesophageal and gastric cancer surgery in the Netherlands between 1989 and 2009. Eur J Cancer 48:1004–1013

    Article  PubMed  Google Scholar 

  12. Wouters MW, Gooiker GA, van Sandick JW, Tollenaar RA (2012) The volume-outcome relation in the surgical treatment of esophageal cancer a systematic review and meta-analysis. Cancer 118:1754–1763

    Article  PubMed  Google Scholar 

  13. Markar SR, Karthikesalingam A, Thrumurthy S, DE Low (2012) Volume-outcome relationship in surgery for esophageal malignancy: systematic review and meta-analysis 2000-2011. J Gastrointest Surg 16:1055–1063

    Article  PubMed  Google Scholar 

  14. Varghese TK, Wood DE, Farjah F, Oelschlager BK, Symons RG, MacLeod KE, Flum R, Pellegrini CA (2011) Variation in esophagectomy outcomes in hospitals meeting leapfrog volume outcome standards. Ann Thorac Surg 91:1003–1010

    Article  PubMed  Google Scholar 

  15. Ghafer AA, Birkmeyer JD, Dimick JB (2009) Variation in hospital mortality associated with inpatient surgery. N Engl J Med 361:1368–1375

    Article  Google Scholar 

  16. Louie BE (2010) Is Esophagectomy the Paradigm for Volume–Outcome Relationships? J Gastrointest Surg 14(Suppl 1):S115–S120

    Article  PubMed  Google Scholar 

  17. Ministero della Salute DOCUMENTO TECNICO DI INDIRIZZO PER RIDURRE IL CARICO DI MALATTIA DEL CANCRO Anni 2011-2013 https://webgate.ec.europa.eu/sanco/heidi/images/9/99/Italy_National_Oncology_Plan_Italian.pdf

  18. Kuppusamy M, Sylvester J, DE Low (2011) In an era of health reform: defining cost differences in current esophageal cancer management strategies and assessing the cost of complications. J Thorac Cardiovasc Surg 141(1):16–21

    Article  PubMed  Google Scholar 

  19. Dikken JL, van Sandick JW, Allum WH, Johansson J, Jensen LS, Putter H, Coupland VH, Wouters MWJM, Lemmens VEP, van de Velde CJH (2013) Differences in outcomes of oesophageal and gastric cancer surgery across Europe. Br J Surg 100:83–94

    Article  PubMed  CAS  Google Scholar 

  20. Padmanabhan RS, Byrnes MC, Helmer SD, Smith RS (2002) Should esophagectomy be performed in a low-volume center? Am Surgeon 68:348–351

    PubMed  Google Scholar 

  21. Aiken LH, Clarke SP, Cheung RB, Sloane DM, Silber JH (2003) Educational levels of hospital nurses and surgical patient mortality. JAMA 290:1617–1623

    Article  PubMed  CAS  Google Scholar 

  22. Jiang K, Cheng L, Wang JJ, Li JS, Nie J (2009) Fast track clinical pathway implications in esophagogastrectomy. World J Gastroenterol 15(4):496–501

    Article  PubMed  Google Scholar 

  23. Li C, Ferri LE, Mulder DS, Ncuti A, Neville A, Lee L, Kaneva P, Watson D, Vassiliou M, Carli F, Feldman LS (2012) An enhanced recovery pathway decreases duration of stay after esophagectomy. Surgery 152(4):606–614

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Uberto Fumagalli.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fumagalli, U., Bersani, M., Russo, A. et al. Volume and outcomes after esophageal cancer surgery: the experience of the Region of Lombardy—Italy. Updates Surg 65, 271–275 (2013). https://doi.org/10.1007/s13304-013-0227-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13304-013-0227-y

Keywords

Navigation