Home P, Riddle M, Cefalu WT, et al. Insulin therapy in people with type 2 diabetes: opportunities and challenges? Diabetes Care. 2014;37(6):1499–508.
Marshall SL, Edidin D, Arena VC, Becker DJ, Bunker CH, Gishoma C, et al. Prevalence and incidence of clinically recognized cases of type 1 diabetes in children and adolescents in Rwanda, Africa. Diabet Med. 2015;32(9):1186–92.
Bahendeka S, Wesonga R, Mutungi G, Muwonge J, Neema S, Guwatudde D. Prevalence and correlates of diabetes mellitus in Uganda: a population-based national survey. Trop Med Int Health. 2016;21(3):405–16.
Ministry of Health, Kenya. STEPwise survey for non-comminicable diseases risk factors 2015 Report. 2015. http://www.who.int/ncds/surveillance/steps/kenya/en/. Accessed 23 Dec 2017.
Ngwiri T, Were F, Predieri B, Ngugi P, Iughetti L. Glycemic control in Kenyan children and adolescents with type 1 diabetes mellitus. Int J Endocrinol. 2015;2015:761759.
McLarty D, Kitange HM, Mtinangi BL, Makene WJ, Swai ABM, Masuki G, et al. Prevalence of diabetes and impaired glucose tolerance in rural Tanzania. Lancet. 1989;333(8643):871–5.
Ministry of Health, Republic of Rwanda. Rwanda non-communicable diseases risk factors report. 2015. http://www.who.int/ncds/surveillance/steps/rwanda/en/. . Accessed 23 Dec 2017.
International Diabetes Federation. IDF diabetes atlas. 8th ed. Brussels: International Diabetes Federation; 2017.
Amendezo E, Walker Timothy D, Karamuka V, Robinson B, Kavabushi P, Ntirenganya C, et al. Effects of a lifestyle education program on glycemic control among patients with diabetes at Kigali University Hospital, Rwanda: a randomized controlled trial. Diabetes Res Clin Pract. 2017;126:129–37.
Ellis K, Mulnier H, Forbes A. Perceptions of insulin use in type 2 diabetes in primary care: a thematic synthesis. BMC Fam Pract. 2018;19(1):70.
Bahendeka S, Ramaiya K, Andrew SB, Fredrick O, Bajaj S, Kalra S, Charlotte BM, Claudine K, Makhoba A. EADSG guidelines: insulin therapy in diabetes. Diabetes Ther. 2018;9(2):449–92.
Shah RB, Patel M, Maahs DM, Shah VN. Insulin delivery methods: past, present and future. Int J Pharm Investig. 2016;6(1):1–9.
Hirsch L, Byron K, Gibney M. Intramuscular risk at insulin injection sites–measurement of the distance from skin to muscle and rationale for shorter-length needles for subcutaneous insulin therapy. Diabetes Technol Ther. 2014;16(12):867–73.
Bhatnagar Arpit, Gupta Varun, Tandon Prashant, et al. Last mile delivery of cold chain medicines—challenges and recommendations. Indian J Pharm Biol Res. 2018;6(1):34–41.
Camberlin P: Climate of Eastern Africa. In: Oxford Research Encyclopedia, Climate SciencE (oxfordrecom/climatescience). edn.: Oxford University Press, USA; 2018: 1–52. http://oxfordre.com/climatescience/view/2010.1093/acrefore/9780190228620.9780190228001.9780190220001/acrefore-9780190228620-e-9780190228512?print=pdf. Accessed 02 Dec 2018.
Chandler C, Gryniewicz CM, Pringle T, Cunningham F. Insulin temperature and stability under simulated transit conditions. Am J Health Syst Pharm. 2008;65(10):953–63.
Vimalavathini R, Gitanjali B. Effect of temperature on the potency & pharmacological action of insulin. Indian J Med Res. 2009;130:166–9.
Shnek DR, Hosteler DL, Bell MA, Olinger JM, Frank BH. Physical stress testing of insulin suspensions and solutions. J Pharm Sci. 1998;87(11):1459–65.
American Association of Diabetes Educators. Teaching injection technique to people with diabetes. American Association of Diabetes Educators 2017. https://www.diabeteseducator.org/docs/default-source/practice/practice-documents/practice-papers/teaching-injection-technique-to-people-with-diabetes.pdf?sfvrsn=0. Accessed 9 Jan 2018.
Hinson AM, Stack BC: Evidence-based medicine: approach and references classification. In: Medical and surgical treatment of parathyroid diseases. Edited by Stack BC, Bodenner DL; 2017. pp. 11–13.
Institute of Medicine (IOM). Clinical practice guidelines we can trust. Washington, DC: The National Academies Press; 2011.
Heneghan C, Badenoch D. Evidence-based medicine toolkit, second edition. Malden: Blackwell Publishing, Inc.; 2006.
Shafaat K, Hussain A, Hussain S, et al. An overview: storage of pharmaceutical products. World J Pharm Sci. 2013;2(5):2499–515.
Ogle GD, Abdullah M, Mason D, Januszewski AS, Besancon S. Insulin storage in hot climates without refrigeration: temperature reduction efficacy of clay pots and other techniques. Diabet Med. 2016;33(11):1544–53.
Funnell MM. Overcoming barriers to the initiation of insulin therapy. Clin Diabet. 2007;25(1):36–8.
Gulam AH, Otieno CFF, Omondi-Oyoo G. Prevalence of psychological insulin resistance among patients with type 2 diabetes at Kenyatta National Hospital, Kenya. Health Sci J. 2017;11:3.
Bin Rsheed A, Chenoweth I. Barriers that practitioners face when initiating insulin therapy in general practice settings and how they can be overcome. World J Diabetes. 2017;8(1):28–39. https://doi.org/10.4239/wjd.v8.i1.28.
Therapeutic Patient Education. Continuing Education Programmes for Health Care Providers in the Field of Prevention of Chronic Diseases. Report of a WHO Working Group. WHO; 1998.
Jansà M, Vidal M. Therapeutic education in chronic patients: the diabetes model. Endocrinol Nutr. 2015;62(2):53–5.
Allen NA, Zagarins SE, Feinberg RG, Welch G. Treating psychological insulin resistance in type 2 diabetes. J Clin Transl Endocrinol. 2017;7:1–6.
Spollett G, Edelman SV, Mehner P, Walter C, Penfornis A. Improvement of insulin injection technique: examination of current issues and recommendations. Diabetes Educ. 2016;42(4):379–94.
Tandon N, Kalra S, Balhara YP, et al. Forum for injection technique (FIT), India: the Indian recommendations 2.0, for best practice in insulin injection technique, 2015. Indian J Endocrinol Metab. 2015;19(3):317–31.
de Meijer PHEM, Lutterman JA, van Lier HJJ, van’t Laar A. The variability of the absorption of subcutaneously injected insulin: effect of injection technique and relation with brittleness. Diabet Med. 1990;7(6):499–505. http://doi.org/10.1111/j.1464-5491.1990.tb01431.x.
American Diabetes Association. Diabetes care in the school and day care setting. Diabetes Care. 2009;32(Suppl 1):S68–72. https://doi.org/10.2337/dc09-S068.
American Diabetes Association. Diabetes and employment. Diabetes Care. 2011;34(Suppl 1):S82–6. https://doi.org/10.2337/dc11-S082.
Donner T. Insulin—pharmacology, therapeutic regimens and principles of intensive insulin therapy. [Updated 2015 Oct 12]. In: De Groot LJ, Chrousos G, Dungan K, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000. Available from: https://www.ncbi.nlm.nih.gov/books/NBK278938/table/insulin-pharmacology.factorcomm/. Accessed 23 Jan 2018.
Kansra UC, Sircar S. Insulin therapy: practical points. J Ind Acad Clin Med. 2000;1(3):285–92.
Selam J-L. Evolution of diabetes insulin delivery devices. J Diabetes Sci Technol. 2010;4(3):505–13.
Ramadan WH, Khreis NA, Kabbara WK. Simplicity, safety, and acceptability of insulin pen use versus the conventional vial/syringe device in patients with type 1 and type 2 diabetes mellitus in Lebanon. Patient Prefer Adher. 2015;9:517–28. https://doi.org/10.2147/PPA.S78225.
Hirsch IB. Does size matter? Thoughts about insulin pen needles. Diabetes Technol Ther. 2012;14(12):1081.
Aronson R, Gibney MA, Oza K, et al. Insulin pen needles: effects of extra-thin wall needle technology on preference, confidence, and other patient ratings. Clin Ther. 2013;35(7):923–33.
Beckton Dickinson: Out Products -BD- Beckton Dickinson. https://www.bd.com/en-uk/products. Accessed 20 Jan 2018.
Pearson TL. Practical aspects of insulin pen devices. J Diabetes Sci Technol. 2010;4(3):522–31.
American Diabetes Association. Insulin Administration. Diabetes care. 2003;26(suppl 1):s121–4.
World Health Organization. Safe management of wastes from health-care activities: a summary. Geneva: World Health Organizatio; 2017. (WHO/FWC/WSH/17.05). Licence: CC BY-NC-SA 3.0 IGO.
Koivisto VA, Felig P. Is skin preparation necessary before insulin injection? Lancet. 1978;8073(1):1072–3.
Frid AH, Kreugel G, Grassi G, et al. New insulin delivery recommendations. Mayo Clin Proc. 2016;91(9):1231–55.
Giving an insulin injection. Available at https://medlineplus.gov/ency/patientinstructions/000660.htm. Accessed 23 Jan 2018.
How to inject insulin. Available at https://www.diabetes.co.uk/insulin/how-to-inject-insulin.html. Accessed 20 Jan 2018.
Birkebaek NH, Solvig J, Hansen B, Jorgensen C, Smedeganard J, Christiansen JS. A 4-mm needle reduces the risk of intramuscular injections without increasing backflow to skin surface in lean diabetic children and adults. Diabetes Care. 2008;31(9):e65–e65. https://doi.org/10.2337/dc2308-0977.
Lo Presti D, Ingegnosi C, Strauss K. Skin and subcutaneous thickness at injecting sites in children with diabetes: ultrasound findings and recommendations for giving injection. Pediatr Diabetes. 2012;13(7):525–33.
Naughten E, Smith MA, Baum JD. At what age do diabetic children give their own injections? Am J Dis Child. 1982;136(8):690–2.
Injecting insulin and children. Available at https://www.diabetes.org.uk/guide-to-diabetes/your-child-and-diabetes/insulin-and-your-child. Accessed 20 Jan 2018.
Siminerio L, Kulkarni K, Meece J, et al. Strategies for insulin injection therapy in diabetes self-management bleeding and bruising. Madison: American Association of Diabetes Educators; 2011.
Kruger DF, LaRue S, Estepa P. Recognition of and steps to mitigate anxiety and fear of pain in injectable diabetes treatment. Diabetes Metab Syndr Obes. 2015;16(8):49–56.
Schober E, Wagner G, Berger G, et al. Prevalence of intentional under- and overdosing of insulin in children and adolescents with type 1 diabetes. Pediatr Diabetes. 2011;12(7):627–31.
Davis EM, Foral PA, Dull RB, Smith AN. Review of insulin therapy and pen use in hospitalized patients. Hosp Pharm. 2013;48(5):396–405. https://doi.org/10.1310/hpj4805-396.
Safe use of insulin in primary care: collaborative baseline audit of insulin administration and documentation by community nurse teams. East & South East England Specialist Pharmacy Services. East of England, London, South Central & South East Coast.
Atun R, Davies JI, Gale EAM, Bärnighausen T, Beran D, Kengne AP, Levitt NS, Mangugu FW, Nyirenda MJ, Ogle GD et al: Diabetes in sub-Saharan Africa: from clinical care to health policy. Lancet Diabetes Endocrinol. 2017. http://doi.org/10.1016/S2213-8587(17)30181-X.
Peck R, Mghamba J, Vanobberghen F, Kavishe B, Rugarabamu V, Smeeth L, Hayes R, Grosskurth H, Kapiga S. Preparedness of Tanzanian health facilities for outpatient primary care of hypertension and diabetes: a cross-sectional survey. Lancet Glob Health. 2014;2(5):e285–92.
Katende D, Mutungi G, Baisley K, Biraro S, Ikoona E, Peck R, Smeeth L, Hayes R, Munderi P, Grosskurth H. Readiness of Ugandan health services for the management of outpatients with chronic diseases. Trop Med Int Health. 2015;20(10):1385–95.
Huffman MD, Rao KD, Pichon-Riviere A, Zhao D, Harikrishnan S, Ramaiya K, Ajay VS, Goenka S, Calcagno JI, Caporale JE et al. A cross-sectional study of the microeconomic impact of cardiovascular disease hospitalization in four low- and middle-income countries. PLoS One. 2011;6(6):e20821. http://doi.org/10.21371/journal.pone.0020821.