The authors are especially grateful to Hiroshi Yoshino MD, Kayoko Ikehara MD, and Shuki Usui MD of Toho University Graduate School of Medicine; Takamasa Ichijo MD of Saiseikai Yokohama-city Tobu Hospital; and the BOOST2 investigators.
No funding or sponsorship was received for this study. The article processing charges were funded by the authors.
The manuscript has received editorial assistance in the form of proofreading by a native English editor certified by ZENIS Co., Ltd.
All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. All authors made significant contributions to study design, analysis, and interpretation of data, as well as preparing and reviewing the manuscript.
The authors have no other relevant affiliations or financial involvement with any organizations or entities with a financial interest in or financial conflict with the subject or materials discussed in the manuscript apart from those disclosed.
Munehide Matsuhisa has received research support from Astellas, Biomedicalnet, Boehringer Ingelheim, Daiichi-Sankyo, Merck (MSD), Nihon Unysis, Novartis, Tanabe-Mitsubishi, and Welby, and speaker honoraria from Astellas, Eli Lilly, Novo Nordisk, Sanofi, Tanabe-Mitsubishi, and Takeda.
Takahisa Hirose is on an advisory panel for Eli Lilly, Novo Nordisk, and Sanofi; research support from Astellas, AstraZeneca, Boehringer Ingelheim, Daiichi-Sankyo, Dainippon-Sumitomo, Eli Lilly, Kissei, Merck (MSD), Novo Nordisk, Ono, Sanofi, Takeda, and Tanabe-Mitsubishi; and received speaker honoraria from AstraZeneca, Boehringer Ingelheim, Daiichi-Sankyo, Eli Lilly, Kissei, Merck (MSD), Novo Nordisk, Ono, Sanofi, Takeda, and Tanabe-Mitsubishi.
The remaining authors Masahiko Miyagi, Hiroshi Uchino, Naoki Kumashiro, Mariko Higa, Koki Shin, Makiko Sasamoto, Hiroji Kitazato and Motoyuki Tamaki have nothing to disclose.
Compliance with Ethics Guidelines
All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee of the Toho University Omori Medical Center Hospital and with the 1964 Helsinki Declaration and its later amendments. Informed consent was obtained from all individual participants included in the study.
Some of the findings from this study were presented at the 60th Annual Meeting of The Japan Diabetes Society, Nagoya, Japan, May, 2017.
The datasets generated during and/or analyzed during the current study are available in the University Hospital Medical Information Network-Clinical Trials Registry (UMIN-CTR), number UMIN000012224.
This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.