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RETRACTED ARTICLE: Correlation between PARP-1 Val762Ala polymorphism and the risk of lung cancer in a Chinese population

  • Research Article
  • Published:
Tumor Biology

This article was retracted on 19 August 2015

Abstract

The aim of this study was to investigate the relationship of the PARP-1 Val762Ala (rs1136410 T>C) polymorphism and the risk of lung cancer. A population-based case–control study of 373 lung cancer patients and 360 healthy control subjects (individually matched on age and gender) in a Chinese population was conducted. Genomic DNA was extracted by the phenol-chloroform method from the peripheral blood. PARP-1 Val762Ala polymorphism was identified using polymerase chain reaction–restriction fragments length polymorphism technique. After adjusting for age, tobacco smoking, gender, smoking index, and drinking status, logistic regression analysis demonstrated that CC genotype in PARP-1 Val762Ala polymorphism had an increased risk of lung cancer compared with TT genotype (OR = 1.59, 95 % CI = 1.03 ~ 2.50, P = 0.048), a statistically difference that still existed when merging CC and TC genotypes (OR = 1.56, 95 % CI = 1.03 ~ 2.44, P = 0.042). However, no obvious difference was found between TT and TC (OR = 1.54, 95 % CI = 0.96 ~ 2.44, P = 0.073). Subgroup analysis by histological type indicated that adenocarcinoma patients had higher frequencies of CC or TC+CC genotypes than healthy controls (CC: OR = 1.85, 95 % CI = 1.12 ~ 3.03, P = 0.015; TC+CC: OR = 1.67, 95 % CI = 1.06 ~ 2.63, P = 0.027, respectively), but no statistically significant difference within each genotype in squamous cell carcinoma or small cell lung cancer (all P > 0.05). Our findings support the view that PARP-1 Val762Ala polymorphism may contribute to an increased risk of lung cancer in the Chinese population, especially for adenocarcinoma.

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Acknowledgments

We would like to acknowledge the helpful comments on this paper received from our reviewers.

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Authors and Affiliations

  1. Department of Medical Oncology, The First Hospital of China Medical University, Nanjing South Street No. 155, Heping District, Shenyang, 110001, People’s Republic of China

    Ping Yu, Yun-Peng Liu, Jing-Dong Zhang, Xiu-Juan Qu, Bo Jin & Ye Zhang

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  1. Ping Yu
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  2. Yun-Peng Liu
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Correspondence to Yun-Peng Liu.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article is available at http://dx.doi.org/10.1007/s13277-015-3784-5.

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Yu, P., Liu, YP., Zhang, JD. et al. RETRACTED ARTICLE: Correlation between PARP-1 Val762Ala polymorphism and the risk of lung cancer in a Chinese population. Tumor Biol. 36, 177–181 (2015). https://doi.org/10.1007/s13277-014-2373-3

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  • DOI: https://doi.org/10.1007/s13277-014-2373-3

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