Skip to main content

Advertisement

SpringerLink
Log in

Long noncoding RNA HOTAIR can serve as a common molecular marker for lymph node metastasis: a meta-analysis

  • Review
  • Published:
Tumor Biology

Abstract

A number of studies have reported that HOTAIR expression levels were higher in cancerous tissues than in corresponding noncancerous tissues and overexpression of HOTAIR was prone to lymph node metastasis. This meta-analysis collected all relevant articles and explored the association between HOTAIR expression levels with lymph node metastasis. A literature collection was conducted by searching electronic databases PubMed, Cochrane Library, OVID, Web of Science, and CNKI (up to March 22, 2014). The odds ratio (OR) and its corresponding 95 % confidence interval (CI) were calculated to assess the strength of the association by using RevMan5.2 software. A total of 748 patients from 8 studies were included in this meta-analysis. The results showed there was a significant difference in the incidence of lymph node metastasis between high HOTAIR expression group and low HOTAIR expression group (OR = 2.81, 95 % CI 1.38–5.70, P = 0.004 random-effects model). This meta-analysis demonstrated that the incidence of lymph node metastasis in patients detected with high HOTAIR expression was higher than that in patients with low HOTAIR expression.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Kim S, Nam H, Lee D. Exploring molecular links between lymph node invasion and cancer prognosis in human breast cancer. BMC Syst Biol. 2011;5 Suppl 2:S4. doi:10.1186/1752-0509-5-S2-S4.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  2. Ellsworth RE, Field LA, Love B, Kane JL, Hooke JA, Shriver CD. Differential gene expression in primary breast tumors associated with lymph node metastasis. Int J Breast Cancer. 2011;2011:142763. doi:10.4061/2011/142763.

    Article  PubMed Central  PubMed  Google Scholar 

  3. Jamieson NB, Morran DC, Morton JP, Ali A, Dickson EJ, Carter CR, et al. MicroRNA molecular profiles associated with diagnosis, clinicopathologic criteria, and overall survival in patients with resectable pancreatic ductal adenocarcinoma. Clin Cancer Res: Off J Am Assoc Cancer Res. 2012;18(2):534–45. doi:10.1158/1078-0432.CCR-11-0679.

    Article  CAS  Google Scholar 

  4. Liu X, Kolokythas A, Wang J, Huang H, Zhou X. Gene expression signatures of lymph node metastasis in oral cancer: molecular characteristics and clinical significances. Curr Cancer Ther Rev. 2010;6(4):294–307. doi:10.2174/157339410793358066.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Weigelt B, Wessels LF, Bosma AJ, Glas AM, Nuyten DS, He YD, et al. No common denominator for breast cancer lymph node metastasis. Br J Cancer. 2005;93(8):924–32. doi:10.1038/sj.bjc.6602794.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Mattick JS, Makunin IV. Non-coding RNA. Hum Mol Genet. 2006;15(Spec No 1):R17–29. doi:10.1093/hmg/ddl046.

    Article  CAS  PubMed  Google Scholar 

  7. Ponjavic J, Ponting CP, Lunter G. Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs. Genome Res. 2007;17(5):556–65. doi:10.1101/gr.6036807.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  8. Moran VA, Perera RJ, Khalil AM. Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs. Nucleic Acids Res. 2012;40(14):6391–400. doi:10.1093/nar/gks296.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  9. Tian D, Sun S, Lee JT. The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation. Cell. 2010;143(3):390–403. doi:10.1016/j.cell.2010.09.049.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  10. Tripathi V, Ellis JD, Shen Z, Song DY, Pan Q, Watt AT, et al. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol Cell. 2010;39(6):925–38. doi:10.1016/j.molcel.2010.08.011.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  11. Tsai MC, Spitale RC, Chang HY. Long intergenic noncoding RNAs: new links in cancer progression. Cancer Res. 2011;71(1):3–7. doi:10.1158/0008-5472.CAN-10-2483.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 2010;464(7291):1071–6. doi:10.1038/nature08975.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. Yang Z, Zhou L, Wu LM, Lai MC, Xie HY, Zhang F, et al. Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol. 2011;18(5):1243–50. doi:10.1245/s10434-011-1581-y.

    Article  PubMed  Google Scholar 

  14. Kim K, Jutooru I, Chadalapaka G, Johnson G, Frank J, Burghardt R, et al. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene. 2013;32(13):1616–25. doi:10.1038/onc.2012.193.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, et al. Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res. 2011;71(20):6320–6. doi:10.1158/0008-5472.CAN-11-1021.

    Article  CAS  PubMed  Google Scholar 

  16. Chen FJ, Sun M, Li SQ, Wu QQ, Ji L, Liu ZL, et al. Upregulation of the long non-coding RNA HOTAIR promotes esophageal squamous cell carcinoma metastasis and poor prognosis. Mol Carcinog. 2013;52(11):908–15. doi:10.1002/mc.21944.

    Article  CAS  PubMed  Google Scholar 

  17. Endo H, Shiroki T, Nakagawa T, Yokoyama M, Tamai K, Yamanami H, et al. Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer. PLoS One. 2013;8(10):e77070. doi:10.1371/journal.pone.0077070.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  18. He X, Bao W, Li X, Chen Z, Che Q, Wang H, et al. The long non-coding RNA HOTAIR is upregulated in endometrial carcinoma and correlates with poor prognosis. Int J Mol Med. 2014;33(2):325–32. doi:10.3892/ijmm.2013.1570.

    CAS  PubMed  Google Scholar 

  19. Lv XB, Lian GY, Wang HR, Song E, Yao H, Wang MH. Long noncoding RNA HOTAIR is a prognostic marker for esophageal squamous cell carcinoma progression and survival. PLoS One. 2013;8(5):e63516. doi:10.1371/journal.pone.0063516.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  20. Nakagawa T, Endo H, Yokoyama M, Abe J, Tamai K, Tanaka N, et al. Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer. Biochem Biophys Res Commun. 2013;436(2):319–24. doi:10.1016/j.bbrc.2013.05.101.

    Article  CAS  PubMed  Google Scholar 

  21. Nie Y, Liu X, Qu S, Song E, Zou H, Gong C. Long non-coding RNA HOTAIR is an independent prognostic marker for nasopharyngeal carcinoma progression and survival. Cancer Sci. 2013;104(4):458–64. doi:10.1111/cas.12092.

    Article  CAS  PubMed  Google Scholar 

  22. Xu ZY, Yu QM, Du YA, Yang LT, Dong RZ, Huang L, et al. Knockdown of long non-coding RNA HOTAIR suppresses tumor invasion and reverses epithelial-mesenchymal transition in gastric cancer. Int J Biol Sci. 2013;9(6):587–97. doi:10.7150/ijbs.6339.

    Article  PubMed Central  PubMed  Google Scholar 

  23. Geng YJ, Xie SL, Li Q, Ma J, Wang GY. Large intervening non-coding RNA HOTAIR is associated with hepatocellular carcinoma progression. J Int Med Res. 2011;39(6):2119–28.

    Article  CAS  PubMed  Google Scholar 

  24. Liu XH, Liu ZL, Sun M, Liu J, Wang ZX, De W. The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer. BMC Cancer. 2013;13:464. doi:10.1186/1471-2407-13-464.

    Article  PubMed Central  PubMed  Google Scholar 

  25. Liu XH, Lu KH, Wang KM, Sun M, Zhang EB, Yang JS, et al. MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5. BMC Cancer. 2012;12:348. doi:10.1186/1471-2407-12-348.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This article is supported by the National Natural Science Foundation of China (grants No. 81160235).

Conflicts of interest

The authors declare that there is no conflict of interests regarding the publication of this paper.

Author information

Authors and Affiliations

  1. Department of Colorectal Surgery, First Affiliated Hospital of Guangxi Medical University, 22 Shuangyong Road, Nanning, 530021, Guangxi, People’s Republic of China

    Bin Cai, Kai Liao & Sen Zhang

  2. Department of Bone and Soft Tissue Neurosurgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China

    Zhenjie Wu

Authors
  1. Bin Cai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zhenjie Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kai Liao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sen Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sen Zhang.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cai, B., Wu, Z., Liao, K. et al. Long noncoding RNA HOTAIR can serve as a common molecular marker for lymph node metastasis: a meta-analysis. Tumor Biol. 35, 8445–8450 (2014). https://doi.org/10.1007/s13277-014-2311-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13277-014-2311-4

Keywords

Search

Navigation