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Association between endothelial nitric oxide synthase 894G>T polymorphism and prostate cancer risk: a meta-analysis of literature studies

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Tumor Biology

Abstract

To date, several studies have been conducted to assess the association between endothelial nitric oxide synthase (eNOS) gene 894G > T polymorphism and prostate cancer (PCa) risk, but the results are conflicting. To derive a more precise estimation of the relationship between 894G > T polymorphism and PCa risk, the present meta-analysis was performed. A total of eight case–control studies were included in this meta-analysis. The pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated to evaluate the associations. Our results suggested that 894G > T polymorphism is associated with PCa risk under codominant (GT vs. GG) (OR = 1.11, 95 % CI = 1.01–1.22, P = 0.04) and overdominant (GT vs. GG + TT) (OR = 1.12, 95 % CI = 1.02–1.23, P = 0.02) models in the overall population, while there are no associations observed under dominant (GT + TT vs. GG), recessive (TT vs. GG + GT), and allelic (T vs. G) models. Moreover, when the eligible studies were stratified according to sources of control, significant association between 894G > T polymorphism and susceptibility of PCa was also identified under codominant (OR = 1.12, 95 % CI = 1.01–1.24, P = 0.03) and overdominant (OR = 1.13, 95 % CI = 1.02–1.25, P = 0.02) models when using healthy individuals as control. However, there are no significant associations found under any genetic models when using BPH patients as control group. In conclusion, the present meta-analysis suggested that the eNOS gene 894G > T polymorphism might be a risk factor in the onset of PCa.

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Authors and Affiliations

  1. Department of Urology, Xiangya Hospital, Central South University, Changsha, 410008, Changsha, Hunan, People’s Republic of China

    Cheng Zhao, Xiongbing Zu, Minfeng Chen, Longfei Liu & Lin Qi

  2. Department of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, People’s Republic of China

    Weiqian Yan

  3. Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA

    Cheng Zhao, Shushan Zhao, Hong Liu, Xia Hu, Renna Luo & Yang Xia

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  1. Cheng Zhao
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  2. Weiqian Yan
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  3. Xiongbing Zu
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  11. Lin Qi
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Correspondence to Lin Qi.

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Zhao, C., Yan, W., Zu, X. et al. Association between endothelial nitric oxide synthase 894G>T polymorphism and prostate cancer risk: a meta-analysis of literature studies. Tumor Biol. 35, 11727–11733 (2014). https://doi.org/10.1007/s13277-014-2097-4

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  • DOI: https://doi.org/10.1007/s13277-014-2097-4

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