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Cytoglobin in tumor hypoxia: novel insights into cancer suppression

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Tumor Biology

Abstract

Emerging new and intriguing roles of cytoglobin (Cygb) have attracted considerable attention of cancer researchers in recent years. Hypoxic upregulation of Cygb as well as its altered expression in various human cancers suggest another possible role of this newly discovered globin in tumor cell response under low oxygen tension. Since tumor hypoxia is strongly associated with malignant progression of disease and poor treatment response, it constitutes an area of paramount importance for rational design of cancer selective therapies. However, the mechanisms involved during this process are still elusive. This review outlines the current understanding of Cygb’s involvement in tumor hypoxia and discusses its role in tumorigenesis. A better perception of Cygb in tumor hypoxia response is likely to open novel perspectives for future tumor therapy.

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Acknowledgments

AN is supported by research grants from Department of Science and Technology, Department of Biotechnology, Government of India, R&D grants from University of Delhi, and University Grants Commission (Under SAP Programme). Financial support from DBT for providing fellowship to RJ is also appreciated. The authors wish to thank Dr. Narayana Shivapurkar, Head, Translational Research Laboratory, Lombardi Cancer Center, Georgetown University for generously providing expert comments on the review.

Conflicts of interest

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Authors and Affiliations

  1. Department of Biochemistry, University of Delhi South Campus, Benito Juarez Marg, New Delhi, 110021, India

    Sankalpa Chakraborty, Rince John & Alo Nag

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  1. Sankalpa Chakraborty
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  2. Rince John
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  3. Alo Nag
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Correspondence to Alo Nag.

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Chakraborty, S., John, R. & Nag, A. Cytoglobin in tumor hypoxia: novel insights into cancer suppression. Tumor Biol. 35, 6207–6219 (2014). https://doi.org/10.1007/s13277-014-1992-z

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  • DOI: https://doi.org/10.1007/s13277-014-1992-z

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