Tumor Biology

, Volume 35, Issue 5, pp 4977–4982 | Cite as

VEGF +405G/C (rs2010963) polymorphisms and digestive system cancer risk: a meta-analysis

  • Qing Guo
  • Sheng-Bin Dai
  • Feng Shen
  • Di Yu
  • Shu-Tong Shen
  • Qu Zhang
  • Jun-Xing Huang
  • Zheng-Dong Wu
Research Article


Vascular endothelial growth factor (VEGF) polymorphisms, specifically +405G/C (rs2010963), reportedly influence the risk for various digestive cancers. However, the consequences of these polymorphisms remain controversial and ambiguous. Therefore, we performed a meta-analysis of 11 studies with VEGF +405G/C genotyping on 2,862 patients and 3,028 controls using the random effects model. We obtained a pooled odds ratio (OR) of 1.04 (95 % confidence interval (CI) = 0.86–1.26) for the recessive genetic model, 1.07 (95 % CI = 0.81–1.42) for the dominant genetic model, 1.09 (95 % CI = 0.81–1.47) for the homozygote comparison, and 1.03 (95 % CI = 0.83–1.27) for the heterozygote comparison. In the subgroup analysis of the recessive model, the OR was 1.20 (95 % CI = 1.02–1.40) in colorectal cancer. These results show that VEGF +405G/C polymorphisms are unlikely to be a major determinant of susceptibility to digestive cancer. Furthermore, the subgroup analysis of recessive model indicates that VEGF +405G/C polymorphisms increase the risk for colorectal cancer.


VEGF +405G/C rs2010963 Polymorphism Cancer Meta-analysis 


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Qing Guo
    • 1
  • Sheng-Bin Dai
    • 1
  • Feng Shen
    • 2
  • Di Yu
    • 3
  • Shu-Tong Shen
    • 3
  • Qu Zhang
    • 4
  • Jun-Xing Huang
    • 1
  • Zheng-Dong Wu
    • 1
  1. 1.Department of RadiotherapyTaizhou People’s HospitalTaizhouChina
  2. 2.Taizhou People’s HospitalTaizhouChina
  3. 3.Nanjing Medical UniversityNanjingChina
  4. 4.Department of RadiotherapySecond People’s Hospital of Lian YungangLian YungangChina

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