Tumor Biology

, Volume 35, Issue 4, pp 3891–3897 | Cite as

Quantitative assessment of the influence of CYP1B1 polymorphisms and head and neck squamous cell carcinoma risk

  • Ming Shen
  • Yuan-Yuan Hu
  • Yu-Kun Hu
  • Long-Chuan Xie
  • Xiao-Ming Xu
  • Ming-Yue Wu
  • Yu-Ming Niu
Research Article


The associations between CYP1B1 polymorphisms and head and neck squamous cell carcinoma (HNSCC) risk have been conflicting. We therefore performed a meta-analysis to derive a more precise relationship. Six published case–control studies were collected; odds ratios (ORs) with 95 % confidence interval (CI) were used to assess the association between CYP1B1 Leu432Val, Asn453Ser polymorphisms, and HNSCC risk. The Sensitivity analysis and publication bias also were performed to guarantee the statistical power. Overall, the pooled OR with 95 % CIs indicated that CYP1B1 Leu432Val polymorphism was significantly related with HNSCC risk (for Val vs. Leu: OR = 1.13, 95 % CI = 1.03–1.25, P = 0.014, P heterogeneity = 0.141; for Val/Val vs. Leu/Leu: OR = 1.30, 95 % CI = 1.06–1.60, P = 0.013, P heterogeneity = 0.253; for Val/Val vs. Leu/Leu + Leu/Val: OR = 1.23, 95 % CI = 1.05–1.46, P = 0.013, P heterogeneity = 0.456). The similar results were also been found in succeeding analysis of HWE and stratified analysis of Caucasian population. Furthermore, no significant association between CYP1B1 Asn453Ser polymorphism and HNSCC risk was found in this meta-analysis. In conclusion, our meta-analysis demonstrates that CYP1B1 Leu432Val polymorphism may be a risk factor for developing HNSCC.


CYP1B1 Polymorphism Head and neck squamous cell carcinoma Meta-analysis 



This work was supported by the National Science Foundation of China (81170993) and the Natural Science Foundation of Taihe Hospital of Hubei University of Medicine (2011QD05). No competing financial interests exist.

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Ming Shen
    • 1
  • Yuan-Yuan Hu
    • 2
  • Yu-Kun Hu
    • 3
  • Long-Chuan Xie
    • 2
  • Xiao-Ming Xu
    • 2
  • Ming-Yue Wu
    • 4
  • Yu-Ming Niu
    • 1
    • 2
  1. 1.Institute of StomatologyNanjing Medical UniversityNanjingPeople’s Republic of China
  2. 2.Department of Stomatology and Evidence-Based Medicine Center, Taihe HospitalHubei University of MedicineShiyanPeople’s Republic of China
  3. 3.Department of Oral and Maxillofacial SurgeryThe First Affiliated Hospital of Anhui Medical UniversityHefeiPeople’s Republic of China
  4. 4.Stomatologic Hospital and CollegeAnhui Medical UniversityHefeiPeople’s Republic of China

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