Tumor Biology

, Volume 35, Issue 3, pp 2747–2751 | Cite as

AU-binding factor 1 expression was correlated with metadherin expression and progression of hepatocellular carcinoma

  • Yingzhuo Yang
  • Peng Kang
  • Jie Gao
  • Chunlin Xu
  • Shimei Wang
  • Haiyu Jin
  • Yunling Li
  • Wenjuan Liu
  • Xia Wu
Research Article


RNA-binding factor 1 (AUF1) was found to be up-regulated in numerous tumors compared with untransformed tissues. Furthermore, it has been identified to regulate mRNAs en masse in hepatocellular carcinoma (HCC). Metadherin (MTDH) as a novel oncogene also promotes tumor progression and metastasis in HCC. Our study aimed to investigate the correlation between AUF1 and MTDH expressions by immunochemistry in 146 HCC patients from Heilongjiang region. AUF1 expression in HCC tumors was higher than that in the matched normal liver tissues. Particularly, AUF1 overexpression was closely associated with tumor size (P < 0.022), TNM stage (P < 0.003), hepatitis B surface antigen status, and AFP serum levels (P < 0.05). Furthermore, AUF1 overexpression led to poor outcome during 5-year follow-up (P < 0.001). Additionally, AUF1 and MTDH expressions were correlated with each other. Our findings suggest that the AUF1 gene may play an important role in HCC progression and be a novel biomarker in the future.


Hepatocellular carcinoma RNA-binding factor 1 Metadherin (MTDH) Biomarker 



We thank the Foundation for Postdoctor of the Heilongjiang Provincial Government (no. LRB2010-355) and PHD of The Second Affiliated Hospital of Harbin Medical University (no. BS2011-23).

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Yingzhuo Yang
    • 1
  • Peng Kang
    • 1
  • Jie Gao
    • 1
  • Chunlin Xu
    • 1
  • Shimei Wang
    • 1
  • Haiyu Jin
    • 1
  • Yunling Li
    • 1
  • Wenjuan Liu
    • 1
  • Xia Wu
    • 1
  1. 1.Department of Infectious DiseaseThe Second Affiliated Hospital of Harbin Medical UniversityHarbinChina

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