Skip to main content
SpringerLink
Log in

Meta-analysis of the association between NQO1 Pro187Ser polymorphism and colorectal cancer in Asians

  • Research Article
  • Published:
Tumor Biology

Abstract

There were a number of studies performed to assess the association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians, but no consensus was available up to now. We conducted a meta-analysis to assess the association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians. Case–control studies investigating the association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians were searched in Pubmed and Wanfang databases. Pooled odds ratio (OR) and 95 % confidence interval (95 % CI) was calculated. Finally, seven studies involving a total of 2,051 cases and 2,798 controls met the inclusion criteria and were included into the meta-analysis. Overall, there was an obvious association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians (Ser versus Pro: OR = 1.42, 95 % CI 1.08–1.87, P = 0.013; SerSer versus ProPro: OR = 1.86, 95 % CI 1.08–3.19, P = 0.024; SerSer/ProSer versus ProPro: OR = 1.61, 95 % CI 1.10–2.35, P = 0.014; SerSer versus ProPro/ProSer: OR = 1.46, 95 % CI 1.02–2.10, P = 0.041). There was low risk of publication bias in the meta-analysis. This meta-analysis suggests that there is an obvious association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.

    Article  PubMed  Google Scholar 

  2. Manceau G, Karoui M, Werner A, Mortensen NJ, Hannoun L. Comparative outcomes of rectal cancer surgery between elderly and non-elderly patients: a systematic review. Lancet Oncol. 2012;13:e525–36.

    Article  PubMed  Google Scholar 

  3. Papagiorgis P. Colorectal cancer: dichotomous or continuum model? Perhaps, a combination of both. Gut. 2013;62(10):1519–20.

    Article  PubMed  Google Scholar 

  4. Church D, Midgley R, Kerr D. Biomarkers in early-stage colorectal cancer: ready for prime time? Dig Dis. 2012;30 Suppl 2:27–33.

    Article  PubMed  Google Scholar 

  5. Andersen V, Holst R, Vogel U. Systematic review: diet-gene interactions and the risk of colorectal cancer. Aliment Pharmacol Ther. 2013;37:383–91.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  6. Peters U, Jiao S, Schumacher FR, Hutter CM, Aragaki AK, Baron JA, et al. Identification of genetic susceptibility loci for colorectal tumors in a genome-wide meta-analysis. Gastroenterology. 2013;144:799–807. e724.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  7. Jiang O, Zhou R, Wu D, Liu Y, Wu W, Cheng N. Cyp2e1 polymorphisms and colorectal cancer risk: a huge systematic review and meta-analysis. Tumour Biol. 2013;34:1215–24.

    Article  PubMed  CAS  Google Scholar 

  8. Dufrasne F, Gelbcke M, Neve J, Kiss R, Kraus JL. Quinone methides and their prodrugs: a subtle equilibrium between cancer promotion, prevention, and cure. Curr Med Chem. 2011;18:3995–4011.

    Article  PubMed  CAS  Google Scholar 

  9. Siegel D, Yan C, Ross D. Nad(p)h: quinone oxidoreductase 1 (nqo1) in the sensitivity and resistance to antitumor quinones. Biochem Pharmacol. 2012;83:1033–40.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  10. Zhao ZQ, Guan QK, Yang FY, Zhao P, Zhou B, Chen ZJ. System review and metaanalysis of the relationships between five metabolic gene polymorphisms and colorectal adenoma risk. Tumour Biol. 2012;33:523–35.

    Article  PubMed  CAS  Google Scholar 

  11. Guha N, Chang JS, Chokkalingam AP, Wiemels JL, Smith MT, Buffler PA. Nqo1 polymorphisms and de novo childhood leukemia: a huge review and meta-analysis. Am J Epidemiol. 2008;168:1221–32.

    Article  PubMed Central  PubMed  Google Scholar 

  12. van der Logt EM, Bergevoet SM, Roelofs HM, Te Morsche RH, Dijk Y, Wobbes T, et al. Role of epoxide hydrolase, nad(p)h: quinone oxidoreductase, cytochrome p450 2e1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer. Mutat Res. 2006;593:39–49.

    Article  PubMed  CAS  Google Scholar 

  13. Ding R, Lin S, Chen D. Association of nqo1 rs1800566 polymorphism and the risk of colorectal cancer: a meta-analysis. Int J Colorectal Dis. 2012;27:885–92.

    Article  PubMed  Google Scholar 

  14. Hamajima N, Matsuo K, Iwata H, Shinoda M, Yamamura Y, Kato T, et al. Nad(p)h: quinone oxidoreductase 1 (nqo1) c609t polymorphism and the risk of eight cancers for Japanese. Int J Clin Oncol. 2002;7:103–8.

    PubMed  CAS  Google Scholar 

  15. Nisa H, Kono S, Yin G, Toyomura K, Nagano J, Mibu R, et al. Cigarette smoking, genetic polymorphisms and colorectal cancer risk: the fukuoka colorectal cancer study. BMC Cancer. 2010;10:274.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  16. Sameer AS, Shah ZA, Syeed N, Rasool R, Afroze D, Siddiqi MA. Nad(p)h: quinone oxidoreductase 1 (nqo1) pro187ser polymorphism and colorectal cancer predisposition in the ethnic kashmiri population. Asian Pac J Cancer Prev. 2010;11:209–13.

    PubMed  Google Scholar 

  17. Su XL, Yan MR, Yang L. Nqo1 c609t polymorphism correlated to colon cancer risk in farmers from western region of inner Mongolia. Chin J Cancer Res. 2012;24:317–22.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  18. Peng XE, Jiang YY, Shi XS, Hu ZJ. Nqo1 609c>t polymorphism interaction with tobacco smoking and alcohol drinking increases colorectal cancer risk in a Chinese population. Gene. 2013;521:105–10.

    Article  PubMed  CAS  Google Scholar 

  19. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.

    Article  PubMed Central  PubMed  Google Scholar 

  20. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.

    Article  PubMed  CAS  Google Scholar 

  21. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.

    PubMed  CAS  Google Scholar 

  22. Dai E, Lu Z, Shi J, Yu Y, Zhang J. The nad(p)h: quinone oxidoreductase 1 gene polymorphism and its association with colorectal cancer. Chin J Clin Oncol. 2004;31:89–91.

    CAS  Google Scholar 

  23. Peng X, Jiang Y, Shi X, Hu Z, Zheng X. Relationship between nqo1 c609t gene polymorphism and risk of colorectal cancer. Chin J Public Health. 2010;26:1078–82.

    Google Scholar 

  24. Shin A, Jung KW, Won YJ. Colorectal cancer mortality in Hong Kong of China, Japan, South Korea, and Singapore. World J Gastroenterol. 2013;19:979–83.

    Article  PubMed Central  PubMed  Google Scholar 

  25. Gilsing AM, Berndt SI, Ruder EH, Graubard BI, Ferrucci LM, Burdett L, et al. Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer. Carcinogenesis. 2012;33:1332–9.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

This study was supported by the National Natural Science Foundation of China (NSFC: 81272745).

Conflicts of interest

None

Author information

Authors and Affiliations

  1. Department of Gastroenterology, Shanghai First People’s Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200097, China

    Hang Zhao, Feng Zhu, Jie Sun & Xiangjun Meng

Authors
  1. Hang Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Feng Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jie Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xiangjun Meng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xiangjun Meng.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhao, H., Zhu, F., Sun, J. et al. Meta-analysis of the association between NQO1 Pro187Ser polymorphism and colorectal cancer in Asians. Tumor Biol. 35, 2111–2116 (2014). https://doi.org/10.1007/s13277-013-1280-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13277-013-1280-3

Keywords

Search

Navigation