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Tumor Biology

, Volume 35, Issue 2, pp 871–879 | Cite as

Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis

  • Shahab Uddin
  • Azhar R. Hussain
  • Omar S. Khan
  • Khawla S. Al-Kuraya
Review

Abstract

Leptin is a multifunctional adipose-derived cytokine that plays a critical role in bodyweight homeostasis and energy balance. Plasma level of leptin is an indicator of the amount of energy stored in adipose tissues. Recently, leptin and leptin receptor dysregulation have been reported in a variety of malignant cells including colorectal cancers (CRCs). There are growing evidence that leptin may be the link between obesity and CRC carcinogenesis. Leptin influence the growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT, and/or MAP kinases. In this review, current understanding of leptin and its receptor’s roles in the pathogenesis of colonogenic cancer has been described.

Keywords

Leptin Ob-R PI3-kinase/AKT pathway Colorectal cancer 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Shahab Uddin
    • 1
  • Azhar R. Hussain
    • 1
  • Omar S. Khan
    • 2
  • Khawla S. Al-Kuraya
    • 1
  1. 1.Human Cancer Genomic Research, Research CenterKing Faisal Specialist Hospital and Research CenterRiyadhSaudi Arabia
  2. 2.Benedictine UniversityLisleUSA

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