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RETRACTED ARTICLE: Association between glutathione S-transferase M 1 null genotype and risk of ovarian cancer: a meta-analysis

  • Research Article
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Tumor Biology

This article was retracted on 20 April 2017

Abstract

Though previous studies investigated the association between glutathione S-transferase M 1 (GSTM1) null genotype and ovarian cancer risk, the effect of GSTM1 null genotype on ovarian cancer risk was still unclear. To comprehensively quantify the association between GSTM1 null genotype and ovarian cancer risk, we performed a meta-analysis. Eleven studies from ten publications were identified from PubMed database. The pooled odds ratio (OR) with its 95 % confidence interval (CI) was used to assess the association. Meta-analysis of the total 11 studies showed that GSTM1 null genotype was not associated with ovarian cancer risk (OR = 1.03, 95 % CI 0.92–1.14, P = 0.625). The cumulative meta-analyses showed a trend of no association between GSTM1 null genotype and ovarian cancer risk as information accumulated by year. There was no evidence of publication bias in the meta-analysis. Meta-analysis of the 11 available studies shows that GSTM1 null genotype is not associated with ovarian cancer risk.

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References

  1. Gayther SA. Inherited risk of ovarian cancer and the implications for screening. Int J Gynecol Cancer. 2012;22 Suppl 1:S12–15.

    Article  PubMed  Google Scholar 

  2. Hall M, Gourley C, McNeish I, Ledermann J, Gore M, Jayson G, et al. Targeted anti-vascular therapies for ovarian cancer: current evidence. Br J Cancer. 2013;108:250–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Beral V, Gaitskell K, Hermon C, Moser K, Reeves G, Peto R. Ovarian cancer and smoking: individual participant meta-analysis including 28,114 women with ovarian cancer from 51 epidemiological studies. Lancet Oncol. 2012;13:946–56.

    Article  CAS  PubMed  Google Scholar 

  4. Liliac L, Amalinei C, Balan R, Grigoras A, Caruntu ID. Ovarian cancer: insights into genetics and pathogeny. Histol Histopathol. 2012;27:707–19.

    CAS  PubMed  Google Scholar 

  5. Ziebarth AJ, Landen Jr CN, Alvarez RD. Molecular/genetic therapies in ovarian cancer: Future opportunities and challenges. Clin Obstet Gynecol. 2012;55:156–72.

    Article  PubMed  Google Scholar 

  6. Bolton KL, Ganda C, Berchuck A, Pharaoh PD, Gayther SA. Role of common genetic variants in ovarian cancer susceptibility and outcome: progress to date from the ovarian cancer association consortium (ocac). J Intern Med. 2012;271:366–78.

    Article  CAS  PubMed  Google Scholar 

  7. Lallas TA, McClain SK, Shahin MS, Buller RE. The glutathione S-transferase M1 genotype in ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2000;9:587–90.

    CAS  PubMed  Google Scholar 

  8. Baxter SW, Thomas EJ, Campbell IG. GSTM1 null polymorphism and susceptibility to endometriosis and ovarian cancer. Carcinogenesis. 2001;22:63–5.

    Article  CAS  PubMed  Google Scholar 

  9. Hayes JD, Flanagan JU, Jowsey IR. Glutathione transferases. Annu Rev Pharmacol Toxicol. 2005;45:51–88.

    Article  CAS  PubMed  Google Scholar 

  10. Hayes JD, Strange RC. Glutathione S-transferase polymorphisms and their biological consequences. Pharmacology. 2000;61:154–66.

    Article  CAS  PubMed  Google Scholar 

  11. Sarhanis P, Redman C, Perrett C, Brannigan K, Clayton RN, Hand P, et al. Epithelial ovarian cancer: influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on P53 expression. Br J Cancer. 1996;74:1757–61.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Hengstler JG, Kett A, Arand M, Oesch-Bartlomowicz B, Oesch F, Pilch H, et al. Glutathione S-transferase T1 and M1 gene defects in ovarian carcinoma. Cancer Lett. 1998;130:43–8.

    Article  CAS  PubMed  Google Scholar 

  13. Goodman JE, Lavigne JA, Hengstler JG, Tanner B, Helzlsouer KJ, Yager JD. Catechol-o-methyltransferase polymorphism is not associated with ovarian cancer risk. Cancer Epidemiol Biomarkers Prev. 2000;9:1373–6.

    CAS  PubMed  Google Scholar 

  14. Spurdle AB, Webb PM, Purdie DM, Chen X, Green A, Chenevix-Trench G. Polymorphisms at the glutathione S-transferase GSTM1, GSTT1 and GSTP1 loci: risk of ovarian cancer by histological subtype. Carcinogenesis. 2001;22:67–72.

    Article  CAS  PubMed  Google Scholar 

  15. Morari EC, Lima AB, Bufalo NE, Leite JL, Granja F, Ward LS. Role of glutathione-S-transferase and codon 72 of P53 genotypes in epithelial ovarian cancer patients. J Cancer Res Clin Oncol. 2006;132:521–8.

    Article  CAS  PubMed  Google Scholar 

  16. Gates MA, Tworoger SS, Terry KL, Titus-Ernstoff L, Rosner B, De Vivo I, et al. Talc use, variants of the GSTM1, GSTT1, and NAT2 genes, and risk of epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2008;17:2436–44.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Khokhrin DV, Khrunin AV, Moiseev AA, Gorbunov VA. Limborskaia SA: [Association of polymorphisms in glutathione-S-transferase and DNA repair genes with ovarian cancer risk in the Russian population]. Genetika. 2012;48:901–4.

    CAS  PubMed  Google Scholar 

  18. Oliveira C, Lourenco GJ, Sagarra RA, Derchain SF, Segalla JG, Lima CS. Polymorphisms of glutathione S-transferase Mu 1 (GSTM1), Theta 1 (GSTT1), and Pi 1 (GSTP1) genes and epithelial ovarian cancer risk. Dis Markers. 2012;33:155–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.

    Article  PubMed  PubMed Central  Google Scholar 

  20. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.

    Article  CAS  PubMed  Google Scholar 

  21. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.

    CAS  PubMed  Google Scholar 

  22. Muellerleile P, Mullen B. Sufficiency and stability of evidence for public health interventions using cumulative meta-analysis. Am J Public Health. 2006;96:515–22.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Egger M. Davey Smith G, Schneider M, Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Attia J, Thakkinstian A, D'Este C. Meta-analyses of molecular association studies: methodologic lessons for genetic epidemiology. J Clin Epidemiol. 2003;56:297–303.

    Article  PubMed  Google Scholar 

  25. Wang B, Huang G, Wang D, Li A, Xu Z, Dong R, et al. Null genotypes of GSTM1 and GSTT1 contribute to hepatocellular carcinoma risk: evidence from an updated meta-analysis. J Hepatol. 2010;53:508–18.

    Article  PubMed  Google Scholar 

  26. Zhu Y, He Q, Wang J, Pan HF. The association between GSTM1 polymorphism and gastric cancer risk: a meta-analysis. Mol Biol Rep. 2012;39:685–91.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Yihua Yin.

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The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article can be found online at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Yin, Y., Feng, L. & Sun, J. RETRACTED ARTICLE: Association between glutathione S-transferase M 1 null genotype and risk of ovarian cancer: a meta-analysis. Tumor Biol. 34, 4059–4063 (2013). https://doi.org/10.1007/s13277-013-0995-5

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  • DOI: https://doi.org/10.1007/s13277-013-0995-5

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